In Vivo Pharmacodynamic Imaging of Proteasome Inhibition by Erin A. Kimbrel, Tina N. Davis, James E. Bradner, Andrew L. Kung

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Pharmacodynamics of interspecies interactions in polymicrobial infections by C. Herzberg, J. G. C. van Hasselt

“…Abstract The pharmacodynamic response of bacterial pathogens to antibiotics can be influenced by interactions with other bacterial species in polymicrobial infections (PMIs). …”
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Population pharmacokinetics and pharmacodynamics of edoxaban in pediatric patients by Peng Zou, Akhilesh Atluri, Peter Chang, Michael Goedecke, Tarek A. Leil

“…Population pharmacokinetic (PK) and pharmacodynamic (PD) analyses were performed to characterize the PK and PK–PD relationships of edoxaban in pediatric patients to identify the covariates that may contribute to inter‐subject variability in PK and PD of edoxaban in pediatric patients, and to compare the PK and PD data between pediatric and adult patients. …”
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Nutrient conditions affect antimicrobial pharmacodynamics in Pseudomonas aeruginosa by Maik Kok, Thomas Hankemeier, J. G. Coen van Hasselt

“…Using pharmacokinetic-pharmacodynamic simulations, we illustrate that the magnitude of the nutrient-driven pharmacodynamic changes impact treatment for clinical dosing strategies of tobramycin. …”
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Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients by Xiaowen Guo, Yang Qiao, Sijie Yin, Fengqin Luo, Lingmei Yi, Jiajia Chen, Man Lu

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Cimetidine Pharmacodynamics and Pharmacokinetics in Healthy Subjects: A Comparison of Tablets and Suspension by ABR Thomson, P Kirdeikis, L Zuk, RE Samuels, P Zarevics

“…These pharmacokinetic variations between cimetidine suspension and tablets may have partially explained the pharmacodynamic differences of the lower area under the pH time curve (0 to 6 h). …”
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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

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The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis by Mubara Azhar, Mohammed S. Alasmari, Ammara Zamir, Hamid Saeed, Faleh Alqahtani, Tanveer Ahmad, Muhammad Fawad Rasool

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In vivo pharmacokinetic and pharmacodynamic study and cutoff of florfenicol against Riemerella anatipestifer in ducks by Hui-Lin Zhang, Fa-Lei Li, Hui-Yang Chen, Ding-Mei Qin, Shu-Jun Sun, Meng-Meng Zhang, Huan-Zhong Ding, Yong Liu

“…This study investigated the pharmacokinetic/pharmacodynamic (PK/PD) integration of florfenicol (FF) against R. anatipestifer by establishing a systemic infection model in ducks. …”
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Vancomycin population pharmacokinetic models: Uncovering pharmacodynamic divergence amid clinicobiological resemblance by Peggy Gandia, Sahira Chaiben, Nicolas Fabre, Didier Concordet

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The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology by Abraham Tonny Hagan, Lei Xu, Benjamin Klugah-Brown, Jialin Li, Xi Jiang, Keith M. Kendrick

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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…To present literature data on clinical presentation, pharmacodynamic and economic efficiency of standard dozes of proton pump inhibitors (PPI) for gastroesophageal reflux disease (GERD).Summary. …”
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Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems by Pankajkumar S. Yadav, Ekta Yadav, Amita Verma, Saima Amin

“…Optimized SNEDDS formulation was composed of Capmul MCM (19.17% w/w), Tween 80 (57.5% w/w), Transcutol P (12.7% w/w), and HCT (4.17% w/w). In vivo pharmacodynamic evaluation in Wistar rats showed considerable increase in pharmacological effect of HCT by SNEDDS formulation as compared with plain HCT.…”
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Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals by Rebecca A. Keel, George G. Zhanel, Sheryl Zelenitsky, David P. Nicolau

“…These results support that the currently recommended antimicrobial dosing regimens generally attain acceptable exposures to achieve the requisite pharmacodynamic targets against the Enterobacteriaceae species; however, they fall short of obtaining optimal bactericidal exposures against P aeruginosa.…”
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Pharmacological and Pharmacodynamic Implications of Nonsteroidal Anti-Inflammatory Drug Therapy in Elderly Arthritic Patients by W Watson Buchanan

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Pharmacodynamics of TRPV1 Agonists in a Bioassay Using Human PC-3 Cells by Daniel Alvarez-Berdugo, Marcel Jiménez, Pere Clavé, Laia Rofes

“…In addition, PC-3 cell bioassays proved useful in the study of TRPV1 pharmacodynamics.…”
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Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration by Liang Xin, Haoxiang Zhu, Haoxiang Zhu, Suping Niu, Xie Han, Hongxian Pang, Jiangfan Li, Ye Hu, Xuhong Wang, Lujin Li, Lujin Li, Yi Fang

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Importance and Role of Pharmacokinetics, Pharmacodynamics and Stability in Nonhospital, Community-Based Parenteral Antimicrobial Therapy by Kathryn Slayter

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A prospective study to evaluate high dose daptomycin pharmacokinetics and pharmacodynamics in spp. infective endocarditis by Simona De Gregori, Annalisa De Silvestri, Mara Capone, Vincenzina Monzillo, Paola Giordani, Raffaele Bruno, Elena Seminari

“…Background: Daptomycin pharmacokinetics and pharmacodynamics data relative to higher doses in patients are necessary for clinical practice. …”
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