Thirty-year trends of anxiety disorders among adolescents based on the 2019 Global Burden of Disease Study by Jing Guo, Fan Yang, Shan Zhang, Xiaohan Liu, Ning Huang

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An Evidence-Based Update on the Impact of Local Antimicrobials as Adjunct to Periodontal Therapy by Nabaz Yahya Hussein, Sadat Abdulla Aziz, Twana Mohammed M. Ways, Omed Amiri, Hisham Al-Obaidi, Dianne Ford

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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking by Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu

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Area under the Curve-Based Dosing of Vancomycin in Critically Ill Patients Using 6-Hour Urine Creatinine Clearance Measurement by Bita Shahrami, Farhad Najmeddin, Saeideh Ghaffari, Atabak Najafi, Mohammad Reza Rouini, Mojtaba Mojtahedzadeh

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Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial by Nour Elkhair Ali, Lamis AbdelGadir Kaddam, Suad Yousif Alkarib, Babikir Gabir Kaballo, Sami Ahmed Khalid, Abdalazim Higawee, Alaa AbdElhabib, Alaa AlaaAldeen, Aled O. Phillips, Amal Mahmoud Saeed

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Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

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Contextualization of Trait Nexus and Gene Action for Quantitative and Qualitative Characteristics in Indian Mustard by Sumanta Prasad Chand, Sandip Debnath, Mehdi Rahimi, Mohd. Shaikhul Ashraf, Pankaj Bhatt, Saima Ahmed Rahin

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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer by Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano, Juan Manuel García-Martínez

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Clinical Burden and Healthcare Resource Use of Asthma in Children in the UK by Gouia I, Joulain F, Zhang Y, Morgan CL, Khan AH

“…Imène Gouia,1 Florence Joulain,1 Yi Zhang,2 Christopher Ll Morgan,3 Asif H Khan4 1HEVA (Health Economics and Value Assessment), Sanofi, Gentilly, France; 2Medical Affairs, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA; 3Epidemiology, Pharmatelligence Ltd, Cardiff, UK; 4Global Medical, Sanofi, Bridgewater, NJ, USACorrespondence: Imène Gouia, Sanofi, 82 Avenue Raspail, Gentilly Cedex, 94255, France, Tel +33786980603, Email Imene.Gouia@sanofi.comBackground: UK pediatric asthma prevalence is among the highest in Europe, and although the clinical and economic burden of asthma in UK adults is well described, childhood asthma data is lacking. …”
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Profiling Key Phytoconstituents in Screw-Pressed <i>Nigella</i> Solid Residue and Their Distribution in Products and Byproducts During Oil Processing by Parbat Raj Thani, Joel B. Johnson, Surya Bhattarai, Tieneke Trotter, Kerry Walsh, Daniel Broszczak, Mani Naiker

“…Its seed oil is used extensively in pharmaceuticals, nutraceuticals, cosmetics, and cooking. …”
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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…Future research trajectories are likely to encompass investigations into the relationship between HF and pyroptosis, as well as clinical studies on pharmaceuticals targeting the NLRP3 inflammasome as a therapeutic approach for HF.Conclusion: This investigation provides a comprehensive bibliometric analysis and synopsis of NLRP3 inflammable-related studies in HF. …”
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Internet-based cognitive–behavioural therapy for insomnia (ICBT-i): a meta-analysis of randomised controlled trials by Jia Chen, Juan Liu, Yuan-yuan Ye, Ni-ka Chen, Ling Lin, Ya-zhen Liu, Ying Lang, Xun-jun Li, Xin-ju Yang, Xiao-jiang Jiang

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Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab by Hans-Christoph Diener, Kathleen A. Day, Sarah Lipsius, Sheena K. Aurora, Nada A. Hindiyeh, Holland C. Detke

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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

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Hereditary angioedema diagnosis evaluation score (HADES): A new clinical scoring system for predicting hereditary angioedema with C1 inhibitor deficiency by Ricardo Zwiener, MD, Rafael Zamora, MD, Carlos María Galmarini, MD, PhD, Laura Brion, PhD, Laura Arias, MD, Andrea Pino, MD, Paula Rozenfeld, PhD

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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

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Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies by Elena Rampanelli, Nadia Romp, Antonio Dario Troise, Jakshana Ananthasabesan, Hao Wu, Ismail Sahin Gül, Sabrina De Pascale, Andrea Scaloni, Fredrik Bäckhed, Vincenzo Fogliano, Max Nieuwdorp, Thi Phuong Nam Bui

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Modification and analysis of context-specific genome-scale metabolic models: methane-utilizing microbial chassis as a case study by M. A. Kulyashov, R. Hamilton, Y. Afshin, S. K. Kolmykov, T. S. Sokolova, T. M. Khlebodarova, M. G. Kalyuzhnaya, I. R. Akberdin

“…M. alcaliphilum 20ZR is becoming an attractive microbial platform for the production of biofuels, chemicals, pharmaceuticals, and bio-sorbents for capturing atmospheric methane. …”
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Fusidic Acid and Lidocaine-Loaded Electrospun Nanofibers as a Dressing for Accelerated Healing of Infected Wounds by Alsulami KA, Bakr AA, Sirwi A, Elfaky MA, Shaik RA, Alshehri BY, Aodah AH, Al Fayez N, Alshehri AA, Almughem FA, Halwani AA, Tawfik EA

“…Khulud A Alsulami,1 Abrar A Bakr,1 Alaa Sirwi,2 Mahmoud A Elfaky,2 Rasheed A Shaik,3 Bayan Y Alshehri,1 Alhassan H Aodah,1 Nojoud Al Fayez,1 Abdullah A Alshehri,1 Fahad A Almughem,1 Abdulrahman A Halwani,4,5 Essam A Tawfik1 1Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, 11442, Saudi Arabia; 2Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 3Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 4Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 5Regenerative Medicine Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi ArabiaCorrespondence: Essam A Tawfik, Email etawfik@kacst.gov.saIntroduction: Wound treatment is a significant health burden in any healthcare system, which requires proper management to minimize pain and prevent bacterial infections that can complicate the wound healing process.Rationale: There is a need to develop innovative therapies to accelerate wound healing cost-effectively. …”
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Influence of different priming treatments on germination potential and seedling establishment of four important hemp (Cannabis sativa L.) cultivars by Saba Latif, Rahmatullah Qureshi, Abdul Rauf, NoshinIlyas, Qaiser Hussain, Syed Sabir Hussain Shah, Sabith Rehman, Arshad Mahmood Khan, Nasrullah Khan, Mostafa A. Abdel-Maksoud, Abdul Malik, Sabiha Fatima, Bushra Hafeez Kiani

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