Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review by Xinyu Wang, Zeyao Yang, Wangang Zhang, Lujuan Xing, Ruiming Luo, Songmin Cao

“…Bioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to their widespread use in the food and pharmaceutical industries. This article reviews the key factors influencing the absorption efficiency of oral bioactive peptides, including issues related to bitter taste perception, challenges in gastrointestinal environmental stability, and limitations in transmembrane transport. …”
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Prevalence and Clinical Spectrum of Liver Disease in Nepalese HIV-Sero-Positive Patients Undergoing Antiretroviral Therapy: A Cross-Sectional Hospital Based Study by Roshan Kumar Jha, Shiv Kumar Sah

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Application of Hyphenated Techniques in Speciation Analysis of Arsenic, Antimony, and Thallium by Rajmund Michalski, Sebastian Szopa, Magdalena Jabłońska, Aleksandra Łyko

“…Recently, speciation analytics has been playing a unique role in the studies of biogeochemical cycles of chemical compounds, determination of toxicity and ecotoxicity of selected elements, quality control of food products, control of medicines and pharmaceutical products, technological process control, research on the impact of technological installation on the environment, examination of occupational exposure, and clinical analysis. …”
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Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines by Klara Dégardin, Aurélie Guillemain, Yves Roggo

“…The fight against medicine counterfeiting is a current focus of the pharmaceutical world. Reliable analytical tools are needed to pursue the counterfeiters. …”
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Combination Olanzapine and Samidorphan for the Management of Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review by Hannah W. Haddad, Elena Boardman, Brooke Williams, Rama Mouhaffel, Adam M. Kaye, Alan D. Kaye

“…OLZ/SAM has been as shown to be a safe and effective pharmaceutical option for the clinical management of schizophrenia and B1D.…”
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Ensuring patient access to gene therapies for rare diseases: Navigating reimbursement and coverage challenges by Diane Berry, Carolyn Hickey, Lisa Kahlman, James Long, Christina Markus, Caitlin K. McCombs

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H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy by Monika Podhorecka, Andrzej Skladanowski, Przemyslaw Bozko

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Chromatographic and Spectral Analysis of Two Main Extractable Compounds Present in Aqueous Extracts of Laminated Aluminum Foil Used for Protecting LDPE-Filled Drug Vials by Samuel O. Akapo, Sajid Syed, Anicia Mamangun, Wayne Skinner

“…In this paper, we described a simple and reliable HPLC method for analysis of an aqueous extract of laminated aluminum foil overwrap used for packaging LDPE vials filled with aqueous pharmaceutical formulations. By means of combined HPLC-UV, GC/MS, LC/MS/MS, and NMR spectroscopy, the two major compounds detected in the aqueous extracts of the representative commercial overwraps were identified as cyclic oligomers with molecular weights of 452 and 472 and are possibly formed from poly-condensation of the adhesive components, namely, isophthalic acid, adipic acid, and diethylene glycol. …”
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Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives by Marjan Talebi, Alireza Ghassempour, Afsoon Feizi, Seyed Abdulmajid Ayatollahi, Mehrdad Faizi

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Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen by Siew Mei Joyce-Tan, Shamsul Mohd Zain, Munavvar Zubaid Abdul Sattar, Nor Azizan Abdullah

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Analysis of Antioxidant Capacity of Chromones in Saposhnikoviae Radix Obtained by Ultrasonic-Assisted Deep Eutectic Solvents Extraction by Xianwen Yue, Fangfei Xu, Peng Lv, Huailei Yang, Huiwei Bao, Yang Xu

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Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives by Ghorab Mostafa M., Al-Said Mansour S., Arafa Reem K.

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Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes by Guangxin Yuan, Yu Bai, Yuhang Zhang, Guangyu Xu

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Impact of bovine serum albumin in simulated body fluid on the dynamic dissolution behavior of bioactive glass S53P4 by Minna Siekkinen, Adrian Stiller, Xiaoju Wang, Leena Hupa

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Practice implications and recommendations for managing codeine misuse and dependence by Bergin Michael, Norman Ian, Foley Michelle, Harris Richard, Rapca Anna, Rich Eileen, Hout Marie-Claire Van

“…Follow-up search strategies involved hand searching and searching of pharmaceutical, health, medical and drug related websites. …”
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The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice by J. N. Boampong, E. O. Ameyaw, B. Aboagye, K. Asare, S. Kyei, J. H. Donfack, E. Woode

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Determination of Mesalamine Related Impurities from Drug Product by Reversed Phase Validated UPLC Method by Trivedi Rakshit Kanubhai, Patel Mukesh C, Kharkar Amit R

“…In essence, the present study provides an improved low detection limit and lower run time for evaluation of pharmaceutical quality of mesalamine delayed-release formulation. …”
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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

“…Among intervention types that can be mimicked by MR, only trials of pharmaceutical interventions could be automatically matched to MR results due to insufficient annotation with Medical Subject Headings ontology. …”
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Development of a CFD simulation for the analysis of CO2 separation percentage using novel [emim][C2N3] ionic liquid solution inside the gas–liquid contactor by Adel Alhowyan, Wael A. Mahdi, Ahmad J. Obaidullah

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Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation by Xinyu Duan, Dong Cui, Mengdi Wang, Chenlu Jin, Xiaochen Cai, Zhiguo Wang, Jian Xu

“…Abstract The introduction of fluoroalkyl groups into pharmaceutical compounds has the potential to enhance their therapeutic properties. …”
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