Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticu... by Taina Viheriälä, Heidi Hongisto, Lyydia Saari, Marika Oksanen, Tanja Ilmarinen, Suvi Väärämäki, Hannu Uusitalo, Pasi Nevalainen, Heli Skottman

“…The molecular and functional assessment of the PXE-specific RPE indicated increased pigmentation and reduced epithelial barrier functions as well as phagocytosis activity as compared to healthy controls. …”
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Deletion of a Putative GPI-Anchored Protein-Encoding Gene Aog185 Impedes the Growth and Nematode-Trapping Efficiency of Arthrobotrys oligospora by Disrupting Transmembrane Transpor... by Hui Peng, Hengqian Lu, Xinyuan Dong, Xiao Liang, Kangliang Sheng, Jingmin Wang, Xiaowei Kong, Xiangdong Zha, Yongzhong Wang

“…Specifically, knockout of Aog185 disrupted transmembrane transport homeostasis during the phagocytosis, cell autophagy, and oxidative phosphorylation processes, which were associated with the fusion of cells and organelle membranes, transport of ions and substrates, and energy metabolism. …”
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Involvement of a 1-Cys peroxiredoxin in bacterial virulence. by Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Suelen Silvana dos Santos, Luis Eduardo Soares Netto, Sandro Rogério de Almeida, Regina Lúcia Baldini

“…Although no differences in the phagocytosis rates were observed when macrophages were infected with wild-type and mutant bacteria in a gentamicin exclusion assay, a higher number of wild-type bacterial cells was found in the supernatant. …”
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Comprehensive Analysis Identifies <i>THEMIS2</i> as a Potential Prognostic and Immunological Biomarker in Glioblastoma by Jianan Chen, Qiong Wu, Anders E. Berglund, Robert J. Macaulay, Arnold B. Etame

“…Additionally, single-cell RNA sequencing data demonstrated that macrophages with a high <i>THEMIS2</i> expression were associated with increased phagocytosis, immune suppression, and enhanced tumor growth. …”
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Impaired Mitophagy: A New Potential Mechanism of Human Chronic Atrial Fibrillation by Shuang Zhou, Weiran Dai, Guoqiang Zhong, Zhiyuan Jiang

“…For the first time, impaired mitophagy, during the phagocytosis of mitochondria, is associated with human chronic AF. …”
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Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State by Marie Koren-Gluzer, Mira Rosenblat, Tony Hayek

“…Moreover, the PON2-null MPM demonstrated enhanced phagocytosis and reactive oxygen species (ROS) production in the basal state and following M1 activation. …”
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Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages by R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard

“…The pathway is mediated specifically through CD163 and is blocked by anti-CD163 antibody or phagocytosis inhibitor. However, levels of pSer473Akt and IL-10 were significantly diminished when scavenging polymorphic Hp2-2:Hb complexes compared to Hp1-1:Hb complexes (P<0.05). …”
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A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation by Julien Villeneuve, Alexis Desmoulière, Antoine Dewitte, Nelly Bordeau, Pierre Costet, Laia Bassaganyas, Jean-Christophe Fricain, Jean Ripoche, Sébastien Lepreux

“…In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. …”
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IMMUNOMODULATORY ACTIVITY OF THE LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS LB 86 ENZYME LYSATE by L. Lаzarenko, L. Orіabinska, T. Bohdan

“…Under the action of this enzyme lysate in vitro, the indicator of phagocytosis (PhI) of the peritoneal cavity macrophages of intact BALB/c mice was enhanced and after its intragastric administration to these mice, the increase of the parameters of spontaneous and stimulated NBT test of macrophages was observed and increase (on the 6th day after its introduction) in the levels of IL-12 and IFN-γ in the blood serum of mice treated with this enzyme lysate was noted against the background of an increase in the ratio of INF-γ/IL-4, which also indicated its potential ability to activate the cellular immune response. …”
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Structural characterization and immunostimulatory activity of a water-soluble polysaccharide from abalone (Haliotis discus hannai Ino) muscle by Linfan Shi, Gengxin Hao, Jun Chen, Junling Wang, Wuyin Weng

“…In addition, AMPP was found to possess potent immunostimulatory activity via rising phagocytosis of RAW264.7 cells and promoting secretion of TNF-α.…”
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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

“…RNA sequencing analysis of microglia isolated from 3xTg mice exhibited transcriptomic changes in lipid metabolism, innate inflammation, and phagocytosis dysfunction; these changes were improved with capsaicin-mediated pharmacological activation of TRPV1 via inhibition of PKM2 dimerization and reduction of SREBP1 activation. …”
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2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis by Fernanda Rosa, Johan S. Osorio, Erminio Trevisi, Francisco Yanqui-Rivera, Charles T. Estill, Massimo Bionaz

“…TZD significantly increased myeloperoxidase but did not affect leukocytes phagocytosis or insulin. TZD increased adipocytes size and had minor effect on expression of PPARγ target genes in mammary epithelial cells but not in adipose tissue. …”
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Emerging insights into intravital imaging, unraveling its role in cancer immunotherapy by Minfeng Yang, Shiqiang Hou, Yao Chen, Hongzhao Chen, Minjie Chu, Song-Bai Liu

“…Currently, several experimental strategies are available to monitor this complexity but most of them fail to facilitate real-time monitoring of the immune response such as cellular phagocytosis and cytolysis. Consequently, the application of intravital imaging has been extensively studied in the domain of cancer immunotherapy. …”
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Investigation of CD47 Expression in Renal Cell Tumors and Evaluation of Its Relationship with Prognostic Parameters by Ömer Faruk Dizibüyük, Zehra Bozdağ, Metin Karakök

“…The interaction of CD47 with SIRPα triggers a “don’t eat me” signal to the macrophages, inhibiting phagocytosis. Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (STs) and hematological malignancies. …”
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Functional analysis of the type II toxin-antitoxin system ParDE in Streptococcus suis serotype 2 by Qibing Gu, Xiayu Zhu, Jiale Ma, Tao Jiang, Zihao Pan, Huochun Yao

“…ΔparDE also exhibited a reduced anti-oxidative stress ability, and ΔparDE was more susceptible to phagocytosis and killing by macrophages. Moreover, the biofilm formation ability of the ΔparDE strain was significantly enhanced compared to ZY05719. …”
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Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression by Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An

“…The OMp showed reduced TNF-α, IL-12, and NO production as well as defective phagocytosis activity compared to nondiabetic controls; however, there was no significant difference with IL-6 production. …”
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Toxin and capsule production by Bacillus cereus biovar anthracis influence pathogenicity in macrophages and animal models. by Treenate Jiranantasak, Andrew P Bluhm, Donald J Chabot, Arthur Friedlander, Richard Bowen, Ian A McMillan, Ted L Hadfield, Airn Hartwig, Jason K Blackburn, Michael H Norris

“…We found Bcbva produced a substantially higher amount of attached poly-ƴ-D-glutamic acid (PDGA) capsule than B. anthracis Ames when grown in medium supplemented with human serum and CO2. In a phagocytosis assay, Bcbva spores showed reduced internalization by mouse macrophages compared to B. anthracis Ames. …”
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CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

“…Our data highlights the importance of sCD22 in driving neuroinflammation and the dual mechanism of targeting CD22 to resolve Aβ-induced inflammation and promote Aβ phagocytosis.…”
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Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres by Paulo Celso Leventi Guimarães, Adenilda Cristina Honorio-França, Cristiane de Castro Pernet Hara, Danny Laura Gomes Fagundes, Silvia Hanna Bilotti Ratto, Eduardo Luzía França

“…The effects of PEG microspheres with adsorbed glycine on viability, superoxide release, phagocytosis, microbicidal activity, and intracellular calcium release of mononuclear (MN) and polymorphonuclear (PMN) colostrum phagocytes were determined. …”
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Interference in Macrophage Balance (M1/M2): The Mechanism of Action Responsible for the Anti-Inflammatory Effect of a Fluorophenyl-Substituted Imidazole by Julia Salvan da Rosa, Eduarda Talita Bramorski Mohr, Tainá Larissa Lubschinski, Guilherme Nicácio Vieira, Thais Andreia Rossa, Marcus Mandolesi Sá, Eduardo Monguilhott Dalmarco

“…Moreover, fluorophenyl-imidazole had the ability to increase the M2 markers IL-4, IL-13, CD206, apoptosis and phagocytosis levels, arginase-1, and FIZZ-1 mRNA expression before LPS stimulation. …”
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