-
81
Chloroquine Treatment Increases Detection of 5-Fluorouracil-Induced Apoptosis In Vivo
Published 2006-07-01“…Apoptosis in an organism is followed almost inevitably by rapid clearance of dying cells via phagocytosis, thus limiting the ability to analyze apoptosis in vivo using classical techniques. …”
Get full text
Article -
82
Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection
Published 2014-01-01“…Innate immune responses include the rapid induction of transcriptional networks that trigger the production of cytokines, chemokines, and cytotoxic molecules; the mobilization of cells including neutrophils and other leukocytes; the engulfment of pathogens by phagocytosis and their delivery to lysosome for degradation; and the induction of autophagy. …”
Get full text
Article -
83
Maternal phthalates exposure promotes neural stem cell differentiation into phagocytic astrocytes and synapse engulfment via IRE1α/XBP1s pathway
Published 2025-01-01“…Conditional knockout or pharmacological inhibition of IRE1α markedly inhibits NSC differentiation into astrocytes and astrocyte reactivity, attenuates synapse phagocytosis, and improves cognitive function. This phenotype is further recapitulated in a human brain organoid model. …”
Get full text
Article -
84
Immunosenescence of Polymorphonuclear Neutrophils
Published 2010-01-01“…Whereas there is consistence about the constant circulating number of PMN throughout aging, the abilities of tissue infiltration, phagocytosis, and oxidative burst of PMN from aged donors are discussed controversially. …”
Get full text
Article -
85
The symbiotic origin of the eukaryotic cell
Published 2023-05-01“…For several decades, the most accepted scenario involved the evolution of an independent lineage of proto-eukaryotes endowed with an endomembrane system, including a nuclear compartment, a developed cytoskeleton and phagocytosis, which engulfed the alphaproteobacterial ancestor of mitochondria. …”
Get full text
Article -
86
Microglia and Synapse: Interactions in Health and Neurodegeneration
Published 2013-01-01“…Many microglial functions, such as phagocytosis, might be overwhelmed during exposure to the abnormal levels of misfolded proteins in their proximity. …”
Get full text
Article -
87
Secondary Hemophagocytic Syndrome: The Importance of Clinical Suspicion
Published 2014-01-01“…Clinically, patients present signs of severe inflammation, with unremitting fever, cytopenias, spleen enlargement, phagocytosis of bone marrow elements, hypertriglyceridemia, and hypofibrinogenemia. …”
Get full text
Article -
88
Imaging of CD47 Expression in Xenograft and Allograft Tumor Models
Published 2013-11-01“…CD47 functions as a marker of “self” by inhibiting phagocytosis of autologous cells. CD47 has been shown to be overexpressed by various tumor types as a means of escaping the antitumor immune response. …”
Get full text
Article -
89
Role of Macrophages in the Pathogenesis of Atopic Dermatitis
Published 2013-01-01“…During the early and short inflammatory phase, macrophages exert proinflammatory functions like antigen-presenting phagocytosis and the production of inflammatory cytokines and growth factors that facilitate the resolution of inflammation. …”
Get full text
Article -
90
The intestinal microbiome as a separate organ
Published 2014-12-01“…Interaction of bacteria with the «host» reminds cooperation of usual cells and can be carried out due to receptor binding, paracrine and humoral pathways, as well as due to phagocytosis and endocytosis. Microbes produce hormone-like substances, analogues of growth factors and neurotransmitters that determine two-way interaction of microflora with the central nervous system and its active metabolic role. …”
Get full text
Article -
91
Selected Mechanisms of Action of Bacteriophages in Bacterial Infections in Animals
Published 2025-01-01“…Due to their complex protein structure, phages can also directly or indirectly modulate immune processes, including innate immunity, by modulating phagocytosis and cytokine reactions, as well as acquired immunity, by producing antibodies and activating effector cells. …”
Get full text
Article -
92
Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection
Published 2018-01-01“…Deficits in zinc adversely impact macrophage function resulting in dysregulation of phagocytosis, intracellular killing, and cytokine production. …”
Get full text
Article -
93
Malakoplakia associated with diarrhoea and colonic lesions after rituximab treatment
Published 2024-12-01“…Malakoplakia is a rare granulomatous condition that occurs due to defective lysosomal digestion during phagocytosis and can mimic inflammatory bowel disease (IBD) or malignancies, particularly in immunosuppressed patients. …”
Get full text
Article -
94
Clot Formation in the Sipunculid Worm Themiste petricola: A Haemostatic and Immune Cellular Response
Published 2012-01-01“…During formation of the clot, microbes or small particles are entrapped. Phagocytosis of self and non-self particles shed from the clot occurs at the clot neighbourhood, demonstrating that clotting is the initial phase of a well-orchestrated dual haemostatic and immune cellular response.…”
Get full text
Article -
95
Inadequate clearance of translocated bacterial products in HIV-infected humanized mice.
Published 2010-04-01“…In HIV-infected mice, however, LPS phagocytosis was insufficient to clear the translocated LPS. …”
Get full text
Article -
96
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain
Published 2013-01-01“…Although inflammation may induce beneficial effects such as pathogen clearance and phagocytosis of apoptotic cells, uncontrolled inflammation can result in detrimental outcomes via the production of neurotoxic factors that exacerbate neurodegenerative pathology. …”
Get full text
Article -
97
Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia
Published 2025-01-01“…Various pathophysiological mechanisms are implicated in ITP pathogenesis, including the production of autoantibodies against components of platelets (PLTs) by B-cells, the activation of the complement system, phagocytosis by macrophages mediated by Fcγ receptors, the dysregulation of T cells, and reduced bone marrow megakaryopoiesis. …”
Get full text
Article -
98
Induction of Cell Activation Processes by Low Frequency Electromagnetic Fields
Published 2004-01-01“…It is known that chronic activation of macrophages is associated with the onset of phagocytosis and leads to increased formation of reactive oxygen species, which themselves may cause DNA damage and are suggested to lead to carcinogenesis. …”
Get full text
Article -
99
Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule.
Published 2025-01-01“…In this way, IFA remarkably reduced capsule thickness and impaired hypercapsule-associated hypermucoviscosity phenotype (HMV), thereby significantly sensitizing hvKP to complement-mediated bacterial killing and accelerating host cell adhesion and phagocytosis. Consequently, IFA facilitated effective bacterial clearance and thus remarkably protected mice from lethal hvKP infection, as evidenced by limited bacterial dissemination and a significant improvement in survival rate. …”
Get full text
Article -
100
Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin
Published 2018-01-01“…However, severe trauma can affect central neutrophil functions, including circulation half-life, chemokinesis, phagocytosis, cytokine release, and respiratory burst. …”
Get full text
Article