Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping by Hannah L. Cornman, Martin P. Alphonse, Arbor Dykema, Alexander L. Kollhoff, Kevin K. Lee, Jaya Manjunath, Emily Z Ma, Varsha Parthasarathy, Junwen Deng, Thomas Pritchard, Anusha Kambala, Melika Marani, Kayla A. Parr, Javid P. Mohammed, Madan M. Kwatra, Jay H. Bream, Won Jin Ho, Shawn G. Kwatra

“…This study highlights a novel form of erythroderma with concomitant Th2 and Th17 dysregulation and introduces a minimally invasive peripheral blood-based immunophenotyping platform that offers a personalized medicine approach to the management of systemic inflammatory diseases.…”
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Pharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients by Ali Fadhel Ahmed, Dzul Azri Mohamed Noor, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Nur Aizati Athirah Daud

“…These findings could facilitate personalized medicine approaches, aiding in better prediction and prevention of SCARs in AED therapy.…”
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Development of the Dutch translational knowledge agenda for inherited metabolic diseases by I. J. Hieltjes, J. H. van derLee, M. C. Groenendijk, G. vanHaaften, P. M. vanHasselt, R. J. Lunsing, G. J. J. vanProoijen, E. M. deRuiter, F. J. vanSpronsen, N. M. Verhoeven‐Duif, A. deVreugd, M. Wagenmakers, H. Zweers, H. Dekker, H. R. Waterham, C. D. vanKarnebeek, R. J. A. Wanders, R. A. Wevers

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The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

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Predicting pediatric patient rehabilitation outcomes after spinal deformity surgery with artificial intelligence by Wenqi Shi, Felipe O. Giuste, Yuanda Zhu, Ben J. Tamo, Micky C. Nnamdi, Andrew Hornback, Ashley M. Carpenter, Coleman Hilton, Henry J. Iwinski, J. Michael Wattenbarger, May D. Wang

“…In the age of personalized medicine, the proposed responsible AI-enabled clinical decision-support system may facilitate pre-operative counseling and shared decision-making within real-world clinical settings.…”
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Do sex differences in the prevalence of ECG abnormalities vary across ethnic groups living in the Netherlands? A cross-sectional analysis of the population-based HELIUS study by Ralf E Harskamp, Anton E Kunst, Hanno L Tan, Renee Bolijn, C Cato ter Haar, Jan A Kors, Pieter G Postema, Marieke B Snijder, Ron J G Peters, Irene G M van Valkengoed

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Genomic Characterization of Carbapenemase-Producing Enterobacteriaceae from Clinical and Epidemiological Human Samples by Alexander Tristancho-Baró, Laura Eva Franco-Fobe, Monica Pilar Ariza, Ana Milagro, Ana Isabel López-Calleja, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…This study analyses CPE trends at a tertiary hospital in Spain from 2021 to 2023, aiming to optimize personalized medicine. <b>Methods</b>: CPE isolates were the first isolate per patient, year, species, and carbapenemase from January 2021 to December 2023. …”
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Clinicopathological and predictive value of MAIT cells in non-small cell lung cancer for immunotherapy by Dongyan Shi, Lin Lin, Yun Chen, Jian Liu, Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Wenhua You, Wen-Hui Li

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Advanced 3D bioprinted liver models with human-induced hepatocytes for personalized toxicity screening by Yue Ma, Runbang He, Bo Deng, Miaomiao Luo, Wenjie Zhang, Lina Mao, Wenxiang Hu, Yilei Mao, Huayu Yang, Pengyu Huang

“…The development of advanced in vitro models for assessing liver toxicity and drug responses is crucial for personalized medicine and preclinical drug development. 3D bioprinting technology provides opportunities to create human liver models that are suitable for conducting high-throughput screening for liver toxicity. …”
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Online patients questions regarding reverse total shoulder arthroplasty pertain to timeline of recovery, specific activities, and limitations by Kyle K. Obana, MD, Dane R.G. Lind, BA, Andrew J. Luzzi, MD, Michaela J. O’Connor, MD, Matthew R. LeVasseur, MD, William N. Levine, MD

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Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis by Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang

“…Abstract The identification of oncogenic gene fusions in diffuse gliomas may serve as potential therapeutic targets and prognostic indicators, representing a novel strategy for treating gliomas consistent with the principles of personalized medicine. This study identified detectable oncogene fusions in glioma patients through an integrated analysis of genomic and transcriptomic data, which encompassed whole exon sequencing and next-generation RNA sequencing. …”
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Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan by Tsukasa Okamoto, Mariko Hanafusa, Taketomo Abe, Takashi Shimamura, Masaru Ito, Yoko Wakai, Torahiko Jinta, Katsuyuki Higa, Yasuhiro Kondoh, Yasumi Okouchi, Ryo Okuda, Masashi Bando, Takafumi Suda, Hiromi Tomioka, Takeo Fujiwara, Masato Takase, Shigemi Yoshihara, Hiroshi Odajima, Yasunari Miyazaki

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Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards by Cosima Strantz, Dominik Böhm, Thomas Ganslandt, Melanie Börries, Patrick Metzger, Thomas Pauli, Andreas Blaumeiser, Alexander Scheiter, Ian-Christopher Jung, Jan Christoph, Iryna Manuilova, Konstantin Strauch, Arsenij Ustjanzew, Niklas Reimer, Hauke Busch, Philipp Unberath

“…In doing so, it lays the foundation for further advances in personalized medicine in oncology and points to a shift towards more efficient, technology-driven clinical decision-making processes. …”
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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction by Jing J. Zhang, Rodrigue Rizk, Xiaoping Li, Brandon G. Lee, Mason L. Matthies, Kennedy A. Bietz, Kang Kim, Kang Kim, Kang Kim, Johnny Huard, Yadong Wang, William C. W. Chen

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Clinical significance of lipid pathway-targeted therapy in breast cancer by Dan Li, Dan Li, Pengcheng Jin, Yiqi Cai, Yiqi Cai, Shijie Wu, Shijie Wu, Xianan Guo, Xianan Guo, Zhiyun Zhang, Zhiyun Zhang, Kexin Liu, Kexin Liu, Panni Li, Panni Li, Yue Hu, Yunxiang Zhou, Yunxiang Zhou

“…We propose the Selective Lipid Metabolism Therapy Benefit Hypothesis, emphasizing the importance of personalized medicine in optimizing lipid pathway-targeted therapy for breast cancer patients.…”
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AAV2 serotype demonstrates the highest transduction efficiency in porcine lung-derived cells by Won Seok Ju, Seokho Kim, Areum Choi, Jae-Yeong Lee, Haesun Lee, Jingu No, Seunghoon Lee, Keonbong Oh, Jae Gyu Yoo

“…Understanding cell type-specific preferences of AAV serotypes offer crucial insight for tailoring AAV vectors to specific tissue and optimizing genome editing strategies, with potential implications for the advancement of personalized medicine and development of treatments for human and livestock.…”
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Phase II study of concomitant radiotherapy with atezolizumab in oligometastatic soft tissue sarcomas: STEREOSARC trial protocol by Nicolas Penel, Dominique Vaur, Juliette Thariat, Alexandre Escande, Jennifer le Guevelou, Colin Debaigt, Esma Saada-Bouzid, Julien Viotti, Nazim Khalladi, David Thibouw, Marie Pierre Sunyach, Laurence Moureau-Zabotto, Mohamed Benchalal, Ovidiu Veresezan, Anne Ducassou, Cecile le Pechoux, Maria Jolnerovski, Celine Bazille, Raphael Serre, Christine Lovera

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Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches by Carmine D'Amico, Manlio Fusciello, Firas Hamdan, Federica D'Alessio, Paolo Bottega, Milda Saklauskaite, Salvatore Russo, Justin Cerioni, Khalil Elbadri, Marianna Kemell, Jouni Hirvonen, Vincenzo Cerullo, Hélder A. Santos

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Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers by Débora Dummer Meira, Victor Nogueira Da Gama Kohls, Matheus Correia Casotti, Luana Santos Louro, Gabriel Mendonça Santana, Thomas Erik Santos Louro, Adriana Madeira Alvares da Silva, Lorena Souza Castro Altoé, Raquel Reis Trabach, Sonia Groisman, Elizeu Fagundes de Carvalho, Jamila Alessandra Perini Machado, Stephanie Seneff, Iúri Drumond Louro

“…This pioneering work on associations between specific genetic variations and health risks with pesticide exposure, emphasizes the importance of personalized medicine and stricter regulation of pesticide use for public health and occupational safety.…”
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Association between relative telomere length and a genetic variant of SIRT1 gene and age-related macular degeneration by L.K. Moshetova, O.P. Dmitrenko, O.I. Abramova, N.S. Karpova, K.I. Turkina, I.N. Saburina

“…Saburina^2,3</b> </p> <p> <b>¹Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation</b> </p> <p> <b>²Research Institute of General Pathology and Pathophysiology, Moscow, Russian Federation</b> </p> <p> <b>³Research Institute of Molecular and Personalized Medicine, Moscow, Russian Federation</b> </p> <p> <i>One of the most important factors predisposing to the development of age-related macular degeneration (AMD) is aging. …”
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