Bio-primed machine learning to enhance discovery of relevant biomarkers by David M. Henke, Alexander Renwick, Joseph R. Zoeller, Jitendra K. Meena, Nicholas J. Neill, Elizabeth A. Bowling, Kristen L. Meerbrey, Thomas F. Westbrook, Lukas M. Simon

“…This method holds promise for advancing personalized medicine by uncovering novel therapeutic targets and understanding the complex interplay of genetic and molecular factors in disease.…”
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Identification of specific risk factors and predictive analytics for cardio-cerebral arterial stenosis: a comparative study utilizing framingham risk stratification insights by Gege Zhang, Sijie Dong, Fanfan Feng, Weihao Kan, Taozhen Shi, Hongmei Ding, Ruiguo Dong

“…The predictive model demonstrated high accuracy, highlighting the importance of personalized medicine in clinical decision-making.…”
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Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia by Yeswanth Ranganathan, Saayaa Nazar, Ravi Shankar Krishnan, Yuvaraj Dinakarkumar, Vijayalakshmi Varadarajan, Lenita Sebastian, Brindha Rethinam

“…The study highlights the impact of personalized medicine, drug discovery, and repurposing through bioinformatics. …”
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Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine by Izadiyan Z, Misran M, Kalantari K, Webster TJ, Kia P, Basrowi NA, Rasouli E, Shameli K

“…The integration of artificial intelligence and machine learning in optimizing liposomal designs promises to revolutionize personalized medicine, paving the way for innovative strategies in disease detection and therapeutic interventions. …”
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The hype around ctDNA guiding an informed perioperative therapeutic strategy in early-stage non-small cell lung cancer by Gaia Passarella, Stefania Canova, Maria Ida Abbate, Giulia Caspani, Luca Sala, Alessandro Russo, Paola Muscolino, Francesca Colonese, Diego Luigi Cortinovis

“…Circulant tumoral DNA (ctDNA) emerged as a promising prognostic and predictive biomarker that may guide the future perioperative strategy and pave the way to personalized medicine also in this exciting field. This narrative review aims to put in the context the employment of ctDNA, give some perspective and suggestions weighing the pros and cons of this technique for our tomorrow clinical practice.…”
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Transforming precision medicine: The potential of the clinical artificial intelligent single‐cell framework by Christian Baumgartner, Dagmar Brislinger

“…By combining clinical data and multimodal molecular inputs, caiSC facilitates personalized medicine, promising enhanced diagnostic precision and tailored therapeutic approaches. …”
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Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…Future initiatives emphasize combinatorial strategies, the development of anti-TB compounds targeting novel pathways, and personalized medicine for TB treatment and prevention. Despite notable advances, persistent challenges such as diagnostic failures and protracted treatment regimens continue to impede progress. …”
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Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

“…Articles related to agriculture, ecology, synthetic work or published in languages other than English were excluded.Results and conclusions The review identifies key challenges related to the efficiency and variability of organoid generation and discusses ongoing efforts to enhance their predictive capabilities in drug screening and personalized medicine. Recent studies utilizing patient-derived organoid models for natural compound screening are highlighted, demonstrating the potential of these models in developing new classes of anticancer agents. …”
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Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC by Yujie Hao, Mingchen Li, Wenxu Liu, Zhenyi Ma, Zhe Liu, Zhe Liu, Zhe Liu

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Dental problems and oral microbiome alterations in ulcerative colitis by Robert Kucharski, Robert Kucharski, Bartosz Kamil Sobocki, Ewa Stachowska, Nikola Bulman, Leszek Kalinowski, Leszek Kalinowski, Karolina Kaźmierczak-Siedlecka

“…The analysis of oral microbiome can be a part of personalized medicine due to the fact that it is a potential biomarker. …”
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Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health by Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Michele Grieco, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci, Mariarosaria Conte

“…This review outlines the role of CBX3 in mechanisms associated with CVD and feasibility for optimizing pre-existing therapy and developing new therapeutic strategies based on personalized medicine.…”
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International initiatives for the study of the human brain: EBRAINS and its Spanish node by Teris Duran, David Ezpeleta, Gemma Aragonès, Javier Mínguez, Emma Muñoz-Moreno, Maria V. Sanchez-Vives, Guillermo Velasco

“…Moreover, the global challenges on neurological and mental disorders, their incidence and prevalence, increasingly require R&D projects directed towards translational and personalized medicine. In an effort to advance these approaches, EBRAINS offers the medical and research sector tools such as The Virtual Epileptic Patient, The Virtual Brain, Medical Informatics Platform, Perturbational Complexity Index, Virtual Research Environment, among others; with the potential to move to clinical practice in the future, as well as other innovations in the spectrum of consciousness disorders or blindness. …”
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Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells by Jarmon G. Lees, Anne M. Kong, Yi C. Chen, Priyadharshini Sivakumaran, Damián Hernández, Alice Pébay, Alexandra J. Harvey, David K. Gardner, Shiang Y. Lim

“…Human induced pluripotent stem cells (iPSCs) can be differentiated in vitro into bona fide cardiomyocytes for disease modelling and personalized medicine. Mitochondrial morphology and metabolism change dramatically as iPSCs differentiate into mesodermal cardiac lineages. …”
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The Wilson's disease - etiology, symptoms in various organs, diagnosis, treatment, prognosis by Patryk Graczyk, Paulina Klaudia Kwaśniewska, Anna Wilewska, Kinga Borowiec, Agnieszka Borowiec, Julia Biernikiewicz, Konstanty Alabrudziński, Milena Biernikiewicz, Bartosz Pomirski, Agata Pomirska

“…Emerging therapies and personalized medicine offer promise for improving outcomes and minimizing long-term complications, highlighting the need for continued research and treatment refinement. …”
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Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities by Pei Pei Lau, Chun-Yu Wei, Min-Rou Lin, Wan-Hsuan Chou, Yu-Jui Yvonne Wan, Wei-Chiao Chang

“…This research offers a valuable framework for advancing personalized medicine and therapeutic strategies for FLD.…”
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Revolutionizing Health Care: The Transformative Impact of Large Language Models in Medicine by Kuo Zhang, Xiangbin Meng, Xiangyu Yan, Jiaming Ji, Jingqian Liu, Hua Xu, Heng Zhang, Da Liu, Jingjia Wang, Xuliang Wang, Jun Gao, Yuan-geng-shuo Wang, Chunli Shao, Wenyao Wang, Jiarong Li, Ming-Qi Zheng, Yaodong Yang, Yi-Da Tang

“…The paper emphasizes the need for human-centric, bias-free LLMs for personalized medicine and advocates for equitable development and access. …”
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A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells by A. Kleijn, J. J. Kloezeman, R. K. Balvers, M. van der Kaaij, C. M. F. Dirven, S. Leenstra, M. L. M. Lamfers

“…These GSCs can be implemented in drug screens to detect patient-specific responses, potentially bridging the translational gap to personalized medicine. Since numerous compounds are available, a rapid and reliable readout for drug efficacies is required. …”
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Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis by In-Woon Baek, Jung Woo Rhim, Kyung-Su Park, Ki-Jo Kim

“…A comprehensive understanding of molecular signatures at the systems level and the discovery of molecular subtypes are the initial steps toward personalized medicine in sJIA. Methods A blood transcriptomic dataset was collected from patients with systemic JIA (sJIA) (n = 168), polyarticular JIA (n = 254), oligoarticular JIA (n = 96), enthesitis-related arthritis (n = 40), and healthy controls (n = 220). …”
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Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer by Ai Sato, Kiyoshi Takagi, Mio Yamaguchi-Tanaka, Jotaro Okushima, Yuto Yamazaki, Akihiro Ito, Takashi Suzuki

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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient. …”
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