Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall by Khaled Algashaamy, Yaohong Tan, Nicolas Mackrides, Alvaro Alencar, Jing-Hong Peng, Joseph Rosenblatt, Juan P Alderuccio, Izidore S. Lossos, Francisco Vega, Jennifer Chapman

“…Prolymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%). Prolymphocytic transformation has also been reported in mantle cell lymphoma (MCL) but only rarely in splenic marginal zone lymphoma (SMZL). …”
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Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity by Florence Vallelian, Marc Pfefferlé, Irina L Dubach, Raphael M Buzzi, Elena Dürst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J Schaer

“…In contrast, extrahepatic inflammation, antigen-specific immunity, and antitumor activity remained unaffected in Ter119 treated animals.Conclusions Our study offers a targeted approach to uncouple CD40-augmented antitumor immunity in peripheral tissues from harmful inflammatoxicity in the liver.…”
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Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease by Bo Li, Yitong Yang, Yingxin Wang, Didi Shan, Jianing Li, Hongxu Wang, Xiaohan Sun, Yao Tang, Yichang Jiao, Xinbo Ji, Zexin Zhan, Bo Kong, Bo Gao, Yu Wang, Ping Sun, Fuchen Liu

“…We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. …”
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Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…Of note, Aβ is not only originated from the brain but also produced peripherally and, via the blood–brain barrier (BBB), can accumulate in the brain and result in the development of AD. …”
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Research status and thinking on the application of moxibustion therapy in cancer patients undergoing chemotherapy (艾灸疗法在肿瘤化疗患者中的应用研究现状与思考)... by MEI Yuwei (梅雨薇), ZHANG Mi (张秘), Li Yingjie (李迎杰), WANG Xue (王雪), WANG Zhihao (王志豪)

“…This paper summarized the research status of moxibustion therapy in treatment of chemotherapy-related adverse reactions such as digestive tract reaction, peripheral neuropathy and bone marrow suppression, and provided reference for improvement of efficacy, safety and normalization of moxibustion therapy in cancer patients undergoing chemotherapy. …”
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Exploring and validating key genetic biomarkers for diagnosis of Parkinson's disease by Wen-bin Teng, Hao-wei Deng, Bing-hua Lv, Shao-dan Zhou, Bin-ru Li, Rui-ting Hu

“…Further validation using 120 peripheral blood mononuclear cells (PBMCs) from PD patients. …”
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Between-Subject and Within-Subject Variation of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest by Jonas Böcker, Marie-Therese Schmitz, Marie-Therese Schmitz, Uwe Mittag, Jens Jordan, Jens Jordan, Jörn Rittweger, Jörn Rittweger

“…To improve quantification of individual responses to bed rest interventions, we analyzed peripheral quantitative computer tomography (pQCT) datasets of the lower leg of 76 participants, who took part in eight different bed rest studies. …”
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Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study by Charles R J C Newton, Albert Ningwa, Kevin Marsh, Richard Idro, Rodney Ogwang, Ronald Anguzu, Pamela Akun, Edward Kayongo

“…All had standardised testing including documentation of the number of seizures in the past month, a rapid malaria test and if positive, the peripheral blood parasite density.Outcomes The primary outcome was the number of seizures in the past month (30 days).Results A total of 164/240 (68%) had malaria. …”
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The novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP, redirects T cell cytotoxicity toward antibody-bound target cells by Chien-Ting Lin, Shang-Ju Wu, Cheng Hao Liao, Reyhung Roc Weng, Chun-Ming Lin

“…In an ex vivo assay, eCD16A/anti-CD3-BFP combined with rituximab effectively eliminated B cells within peripheral blood samples from healthy donors and cancer patients; the effectiveness of this treatment was further enhanced by addition of either autologous or allogeneic γ9δ2 T cells. …”
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Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients... by Ken Sugimoto, Tomohiro Katsuya, Kei Kamide, Tomomi Fujisawa, Izumi Shimaoka, Mitsuru Ohishi, Ryuichi Morishita, Toshio Ogihara, Hiromi Rakugi

“…RNA samples were extracted from peripheral blood, and quantitative real time PCR for all genes was performed using TaqMan method. …”
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The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in colorectal cancer and colorectal anastomotic leakage patients: a retrospe... by Nuo Xu, Jian-Xin Zhang, Jia-Jie Zhang, Zhuo Huang, Lian-Chun Mao, Zhi-Yong Zhang, Wei-Dong Jin

“…Abstract Objective The purpose of this study was to investigate the influence and predictive value of preoperative peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) index on the prognosis of colorectal anastomotic leakage (CAL) patients. …”
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Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngo... by Gayathri Gopakumar, Mauricio J. C. Coppo, Mauricio J. C. Coppo, Andrés Diaz-Méndez, Carol A. Hartley, Joanne M. Devlin

“…In the current study, the transcriptome of peripheral blood mononuclear cells (PBMCs) of the ΔgG-ILTV-vaccinated group of specific-pathogen-free chickens were compared to those of the nonvaccinated group at 7 days post-vaccination. …”
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UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1−/− Microglia In Vitro and In Vivo by Hye Min Lim, Heo Woon, Jung Woo Han, Yoshihiro Baba, Tomohiro Kurosaki, Min Goo Lee, Joo Young Kim

“…Interestingly, UDP-induced Orai1 mobilization to the peripheral region was greatly attenuated in STIM1−/− microglia. …”
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Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study by Palma Ciaramitaro, Mauro Mondelli, Eugenia Rota, Bruno Battiston, Arman Sard, Italo Pontini, Giuliano Faccani, Giuseppe Migliaretti, Aristide Merola, Dario Cocito, Italian Network for Traumatic Neuropathies

“…Serial NCS assessments predict the functional recovery in TN, increasing the accuracy of peripheral nerves surgical decision-making process.…”
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Effects of early maternal care on anxiety and threat learning in adolescent nonhuman primates by Elyse L. Morin, Erin R. Siebert, Brittany R. Howell, Melinda Higgins, Tanja Jovanovic, Andrew M. Kazama, Mar M. Sanchez

“…Here we used a rhesus model of MALT to examine long-term effects on state anxiety and threat/safety learning in 25 adolescents, using a fear conditioning paradigm (AX+/BX-) with acoustic startle amplitude as the peripheral measure. The AX+/BX- paradigm measures baseline startle, fear-potentiated startle, threat/safety cue discrimination, startle attenuation by safety signals, and extinction. …”
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<i>CYP24A1</i> DNA Methylation in Colorectal Cancer as Potential Prognostic and Predictive Markers by Ru-Hua Zhou, Lei Li, Qing-Jian Ou, Yi-Fan Wang, Yu-Jing Fang, Cai-Xia Zhang

“…Our results showed that the hypermethylation of cg02712555 in tumor tissues (hazard ratio, 0.48; 95% confidence interval, 0.24–0.94; <i>p</i> = 0.032) and CpG site 41 in peripheral leukocytes (HR, 0.35; 95%CI, 0.14–0.84; <i>p</i> = 0.019) were both associated with decreased overall mortality in CRC patients. …”
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Compound exposure of 2.8 GHz and 9.3 GHz microwave causes learning and memory impairment in rats by Liu Sun, Xiaoya Wang, Ke Ren, Chuanfu Yao, Haoyu Wang, Xinping Xu, Hui Wang, Ji Dong, Jing Zhang, Binwei Yao, Xiaohui Wei, Ruiyun Peng, Li Zhao

“…Gene ontology (GO) and Protein-protein interaction (PPI) analyses of differential expressed genes (DEGs) in peripheral blood suggested that Htt and Bdnf might be potential indicators to predict microwave. …”
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Identification of blood transcriptome modules associated with suicidal ideation in patients with major depressive disorder by Min Wang, Hailin Xiang, Jinxue Wei, Yikai Dou, Yushun Yan, Yue Du, Huanhuan Fan, Liansheng Zhao, Rongjun Ni, Xiao Yang, Xiaohong Ma

“…This study utilized a weighted gene coexpression network analysis (WGCNA) approach to investigate the associations between gene coexpression modules and SI in individuals with MDD using peripheral blood RNA-seq data from 75 MDD patients with SI (MDD_SI), 82 MDD patients without SI (MDD_nSI), and 149 healthy controls (HC). …”
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Local and Systemic IKKε and NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis by Weiqian Chen, Jin Lin, Heng Cao, Danyi Xu, Bei Xu, Liqin Xu, Lihuan Yue, Chuanyin Sun, Guolin Wu, Wenbin Qian

“…Furthermore, pIKKε and p-p65 expression significantly correlated with biopsy focus score and overall disease activity. Meanwhile, in peripheral blood mononuclear cells from pSS patients, pIKKε, total IKKε, pIKKα/β, and p-p65 were significantly increased by western blot, compared to healthy controls. …”
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Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…The Immune Cell Abundance Identifier (ImmuCellAI) was used to estimate peripheral immune cells abundance of epilepsy. Furthermore, the expression level of hub ARDEGs were detected in patients treated with different epilepsy monotherapies to explore the role of autophagy in the responsiveness of antiepileptic drug therapy. …”
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