Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study by Bram Rochwerg, Jason H. Cheung, Christine M. Ribic, Faraz Lalji, France J. Clarke, Susheel Gantareddy, Nischal Ranganath, Aziz Walele, Ellen McDonald, Maureen O. Meade, Deborah J. Cook, Trevor T. Wilkieson, Catherine M. Clase, Peter J. Margetts, Azim S. Gangji

“…Baseline VL correlated with other measures of volume expansion including serum pro-BNP levels, peripheral edema, and central venous pressure (CVP). …”
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Association between Sensitivity to Thyroid Hormone Indices and Bone Mineral Density in US Males by Shuai Chen, Wucui Huang, Guowei Zhou, Xiaohe Sun, Jie Jin, Zhiwei Li

“…Decreased indices of sensitivity to thyroid hormones are strongly associated with increased lumbar BMD, suggesting that the dysfunction of peripheral and central response to thyroid hormone might contribute to bone loss. …”
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Bland–Altman plot to assess the consistency of arterial and venous blood lactate in the emergency room: a retrospective cohort study by Yongkai Li, Xiaojing He, Dandan Li, Xin Yuan, Jun Xu, Jianzhong Yang

“…Abstract To measure the correlation and agreement between arterial and peripheral venous blood lactate in the emergency room and to assess the predictive value of lactate for the occurrence of cardiac arrest. …”
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Anti-Osteoporosis Is Imperative in Prevention of Progress of Ankylosing Spondylitis by Zheng B, Yu P, Liu H, Liang Y

“…Bin Zheng,* Panfeng Yu,* Haiying Liu, Yan Liang Spine Surgery, Peking University People’s Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Liang, Email liangyan_spine@163.comBackground: Ankylosing spondylitis (AS) is a chronic autoimmune disease that affects the spine and peripheral joints, often leading to kyphosis, joint stiffness, and even ankylosis. …”
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Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
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The Impact of Ischaemic Stroke Subtype on 30-day Hospital Readmissions by Anna Therese Bjerkreim, Andrej Netland Khanevski, Henriette Aurora Selvik, Ulrike Waje-Andreassen, Lars Thomassen, Halvor Naess, Nicola Logallo

“…Predictors of 30-day readmission were higher age, peripheral arterial disease, enteral feeding, and LAA subtype. …”
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Correlation of Interleukin-17-Producing Effector Memory T Cells and CD4+CD25+Foxp3 Regulatory T Cells with the Phosphate Levels in Chronic Hemodialysis Patients by Cheng-Lin Lang, Min-Hui Wang, Kuan-Yu Hung, Sung-Hao Hsu, Chih-Kang Chiang, Kuo-Cheng Lu

“…Methods. 105 patients aged ≥35 years on chronic HD over 3 months were enrolled. The peripheral blood mononuclear cells were collected, cultured, and stimulated by phytohemagglutinin-L, phorbol myristate acetate, and ionomycin at different time points for T cell differentiation. …”
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Long-term exposure to fine particulate matter components with obesity in children and adolescents in China: The age-sex disparities and key effect modifiers by Jinling Wang, Xinyi Li, Guannan Bai, Rachel Huxley, Kejia Hu, Jinna Yuan, Xuelian Zhou, Xiaochi Zhang, Ke Huang, Guanping Dong, Wei Wu, Bingyan Cao, Rongxiu Zheng, Chunlin Wang, Haiyan Wei, Yan Liang, Hui Yao, Feihong Luo, Pin Li, Zhe Su, Ruimin Chen, Shaoke Chen, Jingsi Luo, Hongwei Du, Mireguli. Maimaiti, Jianwei Zhang, Yu Yang, Min Zhu, Qi Zhao, Junfen Fu

“…General central obesity and mixed obesity were more sensitive to PM2.5 exposure than peripheral obesity. As children aged, the effect size of PM2.5 attenuated for general central obesity, remained unchanged for mixed obesity and increased for peripheral obesity. …”
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Identification of a novel SPTB gene splicing mutation in hereditary spherocytosis: a case report and diagnostic insights by Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Xuemei Li, Li Wang, Li Wang, Li Wang, Li Wang, Qian Li, Qian Li, Qian Li, Qian Li, Qianqian Liu, Qianqian Liu, Qianqian Liu, Qianqian Liu, Chengyin He, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Junling Tang, Junling Tang, Junling Tang, Junling Tang

“…Laboratory investigations revealed hemolytic anemia, elevated bilirubin levels, and peripheral blood smear findings consistent with HS. …”
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Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting by I.V. Shklianka, O.J. Zharinov, К.O. Mikhaliev, O.A. Epanchintseva

“…The studied patients’ cohort was characterized by earlier coronary events, signs of the peripheral artery atherosclerosis and other absolute indications for treatment with statins in vast majority of cases. …”
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Temporary spinal cord stimulation combined with lidocaine patch for postherpetic neuralgia in the elderly: a controlled study by Yun Li, Chunhui Hao, Shengtao Wang, Feng Qiu, Xuli Zhao, Tao Sun

“…Combining spinal cord stimulation (SCS) with lidocaine patches may enhance pain relief by targeting central and peripheral pain mechanisms.MethodsThis randomized, controlled, single-blind trial enrolled 97 patients aged ≥60 years with PHN lasting ≥6 months. …”
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Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis by Wenlong Liu, Li Deng, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Huabin Li, Renzhong Luo

“…The relationship between IL-37b and Th1/2 cytokines production in serum and nasal lavage was examined by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-37b. …”
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Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model by Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu

“…Methods The humanized arthritis model, Human peripheral blood mononuclear cells- adjuvant induced arthritis (HuPBMC-AIA) was established, and flow cytometry and immunofluorescence were employed to determine ICOS expression in huPBMC-AIA model. …”
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Outpatient Intravenous Antibiotic Therapy: The Vancouver Hospital experience by Grant Stiver, Amy Wai, Lynne Chase, Luciana Frighetto, Carlo Marra, Peter Jewessen

“…Thirty-four of 144 patients not accepted for outpatient intravenous therapy, were screened by the Infectious Disease Service and Pharmacy, and were discharged on oral antibiotics. Peripherally inserted central catheters were employed in 61 of 107 (57%) patients, peripheral short catheters in 20 (19%), Hickman lines in 14 (13%), and Port-a-caths in 12 (12%). …”
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Impaired Lymphocyte Profile in Schistosomiasis Patients with Periportal Fibrosis by Luciana Santos Cardoso, Andréia de Souza Rocha Barreto, Jamille Souza Fernandes, Ricardo Riccio Oliveira, Robson da Paixão de Souza, Edgar M. Carvalho, Maria Ilma Araujo

“…It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. …”
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Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review by Simone Schiavo, Julian DeBacker, Carine Djaiani, Anuj Bhatia, Marina Englesakis, Rita Katznelson

“…Some evidence supported its use for chronic secondary (peripheral) neuropathic pain including radiation-induced plexus neuropathies, postherpetic neuralgia, and trigeminal neuralgia. …”
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Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies by Mathieu Ferrari, Matteo Righi, Vania Baldan, Patrycja Wawrzyniecka, Anna Bulek, Alexander Kinna, Biao Ma, Reyisa Bughda, Zulaikha Akbar, Saket Srivastava, Isaac Gannon, Mathew Robson, James Sillibourne, Ram Jha, Mohamed El-Kholy, Oliver Muhammad Amin, Evangelia Kokalaki, Mohammed Amin Banani, Rehan Hussain, William Day, Wen Chean Lim, Priyanka Ghongane, Jade R. Hopkins, Dennis Jungherz, Marco Herling, Martin Welin, Sachin Surade, Michael Dyson, John McCafferty, Derek Logan, Shaun Cordoba, Simon Thomas, Andrew Sewell, Paul Maciocia, Shimobi Onuoha, Martin Pule

“…Abstract Peripheral T cell lymphomas are typically aggressive with a poor prognosis. …”
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Histological Ex Vivo Evaluation of the Suitability of a 976 nm Diode Laser in Oral Soft Tissue Biopsies by Gaspare Palaia, Federico Renzi, Daniele Pergolini, Alessandro Del Vecchio, Paolo Visca, Gianluca Tenore, Umberto Romeo

“…A 976 nm diode laser demonstrated good surgical effectiveness that provoked little peripheral damage in the cut edges and allowed a safe histological diagnosis. …”
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Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission by Zhang ZY, Wang F, Zhou G

“…This study explored the role of NAD+ in modulating mitochondrial fission and apoptosis in T cells under the OLP immune-inflammatory environment.Patients and Methods: T cells and plasma were isolated from peripheral blood. Mitochondrial morphology was characterized by transmission electron microscopy and Mito-Tracker staining. …”
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Differential between Protein and mRNA Expression of CCR7 and SSTR5 Receptors in Crohn's Disease Patients by Nathalie Taquet, Serge Dumont, Jean-Luc Vonesch, Didier Hentsch, Jean-Marie Reimund, Christian D. Muller

“…When compared to healthy donors, SSTR5 was over-expressed 417 ± 71 times in CD peripheral blood mononuclear cells (PBMCs). Flow cytometry experiments showed no correlation between mRNA and protein expression for SSTR5 in PBMCs. …”
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