Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used by Marzena Tylicka, Ewa Matuszczak, Maria Karpińska, Adam Hermanowicz, Wojciech Dębek, Halina Ostrowska

“…Proteasome activity was assessed using a Suc-Leu-Leu-Val-Tyr-AMC peptide substrate. Elevation of plasma proteasome activity was noted in children after laparoscopic and open abdominal surgeries. …”
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Combined delivery of IL12 and an IL18 mutant without IL18BP-binding activity by an adenoviral vector enhances tumor specific immunity by Yan Cheng, Renjie Luo, Erguang Li

“…IL12 was expressed as a single chain IL12 (scIL12) peptide composed of the IL12/p40 and IL12/p35 subunits. …”
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The Effects of Exenatide Once Weekly (EXQW) and Exenatide Twice a Day (EXBID) on Beta-Cell Function in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis by Jie Wang, Xinye Jin, Ping An, Songyan Yu, Yiming Mu

“…In patients with type 2 diabetes mellitus (T2DM) and poor glycemic control receiving metformin (MET), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are recommended as the adjunctive therapy. …”
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Impact of Microwave Time on the Structure and Functional Properties of Glycosylated Soy 7S Globulins by Jixin Zhang, Tao Cui, Lan Zhang, Huiqing Xu, Jingguo Xu, Jun Wang

“…Additionally, microwaving for ≤90 s led to increased peptide modifications, with carbamylation and deamidation being the most prevalent. …”
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DIABETES MELLITUS IN PATIENTS WITH LIVER CIRRHOSIS: NEW TREATMENT OPTIONS by L. Yu. Morgunov

“…This article deals with the correction of carbohydrate metabolism in patients with cirrhosis and hepatocellular insufficiency of insulin analogs, biguanides, drugs with incretin effect — dipeptidyl peptidase‑4 inhibitors, agonists of glucagon-like peptide‑1, inhibitors of sodium-glucose cotransporter 2 diabetes. …”
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Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS by Jianan Zhang, Yuko Tsutsui, Hengyi Li, Tongqing Li, Yueyue Wang, Salma Laraki, Sofia Alarcon-Frias, Steven E. Stayrook, Daryl E. Klein

“…This includes beta-strands in dROS1’s third Fibronectin type III (FNIII) domain and a C-terminal peptide in BOSS’ ECR. Our mutagenesis studies, coupled with AlphaFold complex predictions, support a binding interaction mediated by a hydrophobic interaction and beta-strand augmentation between these regions. …”
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Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ by Babak Baban, Hesam Khodadadi, Kumar Vaibhav, Cristina Marchetti, Carlo Riccardi, Mahmood S. Mozaffari

“…Mice subjected to unilateral renal IRI were treated with the following agents before restoration of renal blood flow: cannabidiol, DMSO, transactivator of transcription- (TAT-) GILZ, or the TAT peptide. Thereafter, kidney cells were prepared for flow cytometry analyses. …”
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Evaluation of B cell related markers and autoantibodies in rheumatoid arthritis patients treated with abatacept by Ting Wang, Natalia V. Giltiay, Christian Lood, Ning Wang, Bobby Kwanghoon Han

“…Baseline levels and longitudinal changes of markers were assessed between responders and nonresponders.ResultsBaseline levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies (p=0.01), IgM rheumatoid factor (RF) (p=0.02), CXC chemokine ligand 13 (CXCL13, p=0.02), sCD23 (p<0.05), as well as frequencies of CD19+CD11c+IgD-CD27- B cells (p=0.04), were higher in responders than nonresponders. …”
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Expression of the Gene Encoding the Brucella abortus BAB1-0278 Antigen in Probiotic Lactococcus lactis Bacteria by donya kazemi, abbas doosti, mostafa Shakhsi niaee

“…Materials and Methods: The gene construction design contains a signal peptide sequence in the nisin-based expression vector (pN3z8148-Usp45-BAB1-0278) and is synthesized by GENEray. …”
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Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers by Howida A. Fetouh, Engy E. A. Aleem, Najiyah H. Mohammed, Jihad M. Abd-Almajeed Aldesouky, Amel M. Ismail

“…Release kinetic depend on physicochemical characteristics (porosity, swelling ratio as well as peptide and amino acid sequence). Both IDDs showed negative zeta potential indicating stability against aggregation. …”
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Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair by Yuankun Zhai, Zhuang Zhou, Xiaojie Xing, Mark Nuzzle, Xinping Zhang

“…Utilizing transgenic mouse models in conjunction with high-resolution multiphoton laser scanning microscopy (MPLSM), we have separately evaluated bone and vessel formation in the superior and dura periosteum before and after injury, as well as following intermittent treatment of recombinant peptide of human parathyroid hormone (rhPTH), Teriparatide. …”
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Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma by Zheng Gong, Ming Chen, Jie Miao, Chao-Jie Han, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…In this study, we constructed a fusion protein linking CRT/39-272 to an ovalbumin (OVA) peptide (residues 182–297, OVAp) and used the fusion protein (OVAp-CRT) to examine the adjuvant effect of CRT. …”
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Antifungal Activity and Major Bioactive Compounds of Water Extract of Pangium edule Seed against Aspergillus flavus by Kharisma I. Listyorini, Harsi D. Kusumaningrum, Hanifah N. Lioe

“…LC-MS/MS profile showed that different compounds belong to fatty acid, amino acid, glycoside, and peptide were found as major active compounds in the fractionated water extract. …”
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Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease by Sukdev Manna, Sankha Shubhra Chakrabarti, Rohit Singh, Indrajeet Singh Gambhir

“…Hepcidin, a liver-derived peptide, has been identified as the key systemic regulator of iron homeostasis. …”
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Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease by Yong Hui Nies, Wei Ling Lim, Norwahidah Abd Karim, Mohamad Fairuz Yahaya, Seong Lin Teoh

“…This study explores the neuroprotective potential of exogenous human metallothionein 2 (hMT2) peptide in a rotenone-induced PD zebrafish model.MethodsAdult zebrafish were divided into four groups: control, rotenone-treated, hMT2 pre-treatment, and hMT2 co-treatment. …”
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A retrospective analysis of migraine prophylaxis with anti-CGRP monoclonal antibodies at the hospital of Lithuanian University of Health Sciences Kaunas Clinics by V. Karpavičiūtė, K. Statkevičienė, G. Žemgulytė

“…Preventive treatment of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) is currently being widely investigated worldwide. …”
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Protracted Hypocalcemia following 3.5 Parathyroidectomy in a Kidney Pancreas Recipient with a History of Robotic-Assisted Roux-en-Y Gastric Bypass by Hugo Bonatti, Naureen Iqbal, Catherine Kling, Willie Melvin, James Broome

“…A 41-old-year morbidly obese female with c-peptide negative diabetes mellitus and renal failure had RYGBP. …”
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The Effect of Whey Protein Consumption on Postprandial Glucose, Insulin and Incretin Responses in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Acute-Term... by Zahra Salimi, Maryam Asadi, Anahita Mansoori

“…Results: The pooled analysis of the included trials indicated a significant reduction in the mean of glucose in the area under the curve [standard mean difference (SMD)=-1.295, 95% CI: -1.878 to -0.712, P<0.001] and also an increase in the mean of insulin, gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (SMD=0.562, 95% CI: 0.303 to 0.822, P<0.001, SMD=0.349, 95% CI: 0.074 to 0.624, P=0.013 and SMD=0.439, 95% CI: 0.154 to 0.724, P=0.003, respectively) in participants who consumed whey protein compared with the control group. …”
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Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes by Xiu Zhang, Shengbang Wang, Wei Wang, Liumei Song, Shuo Feng, Jingping Wang, Tong Kang, Peiwen Yang, Ning Wang, Pengju Yang, Ruimin Bai, Yongping Shao, Yan Zheng

“…Extracellular cold-inducible RNA-binding protein (eCIRP) has been shown to play a role in various acute and chronic inflammatory diseases. C23, a short peptide derived from CIRP, competitively binds CIRP receptors and reduces damage in inflammatory diseases. …”
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The Role of Microbial Aspartic Protease Enzyme in Food and Beverage Industries by Jermen Mamo, Fassil Assefa

“…According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology, proteases are classified in enzymes of class 3, the hydrolases, and the subclass 3.4, the peptide hydrolases or peptidase. Proteases are generally grouped into two main classes based on their site of action, that is, exopeptidases and endopeptidases. …”
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