C-28 linker length modulates the activity of second-generation HIV-1 maturation inhibitors by K. C. Yuvraj, Aradhana Singh, Sayantani Datta, Ritika Das, Pranjal Raj Saxena, Subash Chapagain, T. J. Nitz, Carl Wild, Ritu Gaur

“…Abstract Maturation inhibitors (MIs) block HIV-1 maturation by preventing the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a first-in-class MI, displayed sub-optimal efficacy in clinical trials due to presence of SP1:V7A polymorphism in the Gag protein.This polymorphism is inherently present in HIV-1 subtype C and conferred resistance to BVM. …”
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A Case of Reverse Takotsubo Cardiomyopathy Incited by a Spinal Subdural Hematoma by Kyle Sanchez, Steven Glener, Nathan E. Esplin, Okorie N. Okorie, Amay Parikh

“…Troponin levels and brain natriuretic peptide (BNP) were elevated, and echocardiogram revealed an ejection fraction (EF) of less than 20%. …”
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Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation by Karla Salgado-Puga, Roberto A. Prado-Alcalá, Fernando Peña-Ortega

“…Alzheimer’s disease (AD) is associated with an early hippocampal dysfunction, which is likely induced by an increase in soluble amyloid beta peptide (Aβ). This hippocampal failure contributes to the initial memory deficits observed both in patients and in AD animal models and possibly to the deterioration in activities of daily living (ADL). …”
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The assembly factor Reh1 is released from the ribosome during its initial round of translation by Sharmishtha Musalgaonkar, James N. Yelland, Ruta Chitale, Shilpa Rao, Hakan Ozadam, David W. Taylor, Can Cenik, Arlen W. Johnson

“…We propose that Reh1 is displaced by the elongating peptide chain, making it the last assembly factor released from the nascent 60S subunit during its initial round of translation.…”
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Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (Aβ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. …”
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Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase by Silvia Biggi, Lucia Buccarello, Alessandra Sclip, Pellegrino Lippiello, Noemi Tonna, Cristiano Rumio, Daniele Di Marino, Maria Concetta Miniaci, Tiziana Borsello

“…In addition, taking advance of the specific JNK inhibitor peptide, D-JNKI1, we defined JNK action on the SNARE complex formation. …”
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The Oxytocin-Oxytocin Receptor System and Its Antagonists as Tocolytic Agents by Nikolaos Vrachnis, Fotodotis M. Malamas, Stavros Sifakis, Efthymios Deligeoroglou, Zoe Iliodromiti

“…However, the quest for oxytocin receptor antagonists with a better pharmacological profile has led to the synthesis of peptide and nonpeptide molecules such as barusiban, retosiban, L-368,899, and SSR-126768A. …”
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Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction by Ekaterina A. Saburova, Alexander N. Vasiliev, Violetta V. Kravtsova, Elena V. Ryabova, Andrey L. Zefirov, Olga I. Bolshakova, Svetlana V. Sarantseva, Igor I. Krivoi

“…In Drosophila line with expression of human amyloid-β42 peptide itself, parameters analyzed did not differ from controls, suggesting the specificity of APP effects. …”
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Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering by Dominika Skołuba, Dariusz Sobolewski, Adam Prahl, Edyta Proniewicz

“…Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, and Aaa[D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, were deposited onto colloidal Au particles of 20 nm size. …”
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Controllable intein splicing and N-terminal cleavage at mesophilic temperatures by Taylor A. McNeal, Joel Weinberger, Geraldy L. S. Liman, Tia M. Ariagno, David W. Wood, Thomas J. Santangelo, Christopher W. Lennon

“…The ability of inteins to specifically rearrange peptide bonds has proven exceptionally useful in protein engineering, thus, methods to control intein activity are of considerable interest. …”
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Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure by Georgios Aidonidis, Ioannis Kanonidis, Vasileios Koutsimanis, Till Neumann, Raimund Erbel, Georgios Sakadamis

“…Clinical parameters, BNP (Brain Natriuretic Peptide) and signal-averaged-ECG data (SAECG) were recorded up to 72 hours. …”
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Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast by Po-Chang Chiu, Yuri Nakamura, Shinichi Nishimura, Toshitsugu Tabuchi, Yoko Yashiroda, Go Hirai, Akihisa Matsuyama, Minoru Yoshida

“…Ferrichrome is a fungal-type siderophore synthesized by nonribosomal peptide synthetase (NRPS). Herein we show that ferrichrome induces adaptive growth of fission yeast on high ammonium media. …”
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miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape by Fang Chen, Dandan Zhao, Yongfang Xu, Yi Zhang, Min-Hsuan Chen, Khyatiben V. Pathak, Nate Hansen, Brooke Lovell, Yong Liang, Katrina Estrella, Wei-Le Wang, Lucy Ghoda, Russell Rockne, Xiwei Wu, Haris Ali, Jianhua Yu, Michael A. Caligiuri, Stephen J. Forman, Jeff M. Trent, Ya-Huei Kuo, Ling Li, Piotr Swiderski, Jianying Zhang, Marcin Kortylewski, Le Xuan Truong Nguyen, Patrick Pirrotte, Mark Boldin, Guido Marcucci, Bin Zhang

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Clinical Effect of Hufu Copper Scraping on Shoulder-Hand Syndrome after Stroke by Lianyi He, Xinyu Chen, Yuejuan Zhang

“…The intervention effect, occurrence of adverse reactions during the intervention, pain, swelling degree of affected hands, serum calcitonin gene-related peptide (CGRP), substance P (SP), and Barthel index before and after 2 months of intervention were compared between the two groups. …”
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A Case of Primary Amyloidosis Involving Liver, Stomach, Intestines, and Heart without Evident Kidney Involvement by L. S. Kholopov, N. B. Gubegrits, O. A. Dyadyk, Yu. E. Chirkov, Yu. V. Tsohoyeva

“…Decreased hemoglobin levels, elevated levels of alkaline phosphatase, gamma-glutamyltransferase, and N-terminal prohormone of brain natriuretic peptide, signs of heart failure with preserved ejection fraction, and hepatomegaly became the basis for a clinical suspicion of AL amyloidosis and puncture liver biopsy. …”
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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes by Daniel Espes, Mats Martinell, Per-Ola Carlsson

“…Study participants were characterized with regard to BMI, waist and hip circumference, blood pressure, and fasting plasma blood lipids, creatinine, glucose, HbA1c, and C-peptide. HOMA2 indices were calculated. Betatrophin was 40% higher in patients with type 2 diabetes (893±80 versus 639±66 pg/mL). …”
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Estimates of Prevalence of Pulmonary Hypertension according to Different International Definitions by Richa Tyagi, Surya Kant, Akshyaya Pradhan, Anupam Wakhlu, Darshan Kumar Bajaj, Jyoti Bajpai

“…This was a cross-sectional study in which all the patients of ILDs (n = 239) attending the outdoor and indoor Department of Respiratory Medicine, King George’s Medical University, India, for the duration of one year were subjected to transthoracic echocardiography along with measurement of serum pro-B-type natriuretic peptide (BNP) and troponin T values. The data were analyzed using the different definitions, and the prevalence was compared. …”
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Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae. by Md Nahian, Muhammad Shahab, Md Rasel Khan, Shopnil Akash, Tanjina Akhtar Banu, Murshed Hasan Sarkar, Barna Goswami, Sanjana Fatema Chowdhury, Mohammad Ariful Islam, Ahmed Abu Rus'd, Shamima Begum, Ahashan Habib, Aftab Ali Shaikh, Jonas Ivan Nobre Oliveira, Shahina Akter

“…This study introduced a strong peptide vaccine candidate that has the potential to contribute to the development of a rapid and cost-effective solution for combating SPN. …”
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Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction by Line Lisbeth Olesen, Thomas Vauvert F. Hviid

“…N-terminal fragment-pro-B-type natriuretic peptide (NT-proBNP) and uric acid values were inversely related to EF. …”
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Comparison of natural and artificial vasopressin deficiency: why the latter is lethal? by D. Zelena

“…The avp gene consists of a signal peptide, AVP, neurophysin 2 and a C-terminal glycopeptide. …”
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