Angiotensin-Converting Enzyme 2: The First Decade by Nicola E. Clarke, Anthony J. Turner

“…The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin-converting enzyme (ACE) mediating an increase in blood pressure. …”
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Effectiveness and Safety of Newer Antidiabetic Medications for Ramadan Fasting Diabetic Patients by Ehab Mudher Mikhael

“…New glucose-lowering classes like dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 receptor agonist (GLP-1 RA), and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are efficacious in controlling blood glucose level with less tendency to induce hypoglycemia and thus may constitute a good choice for diabetic patients during Ramadan. …”
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Epitope mapping of recombinant Salmonella enterica serotype Heidelberg flagellar hook-associated protein by in silico and in vivo approaches by Hung-Yueh Yeh

“…The results show that both approaches identified three common shared consensus peptide epitope sequences at the positions of 77–95, 243–255 and 358–373 in the Salmonella serotype Heidelberg FlgK protein. …”
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Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin by Satoru Ken Nishimoto, Miyako Nishimoto

“…The binding site for fibronectin is in a MGP C-terminal peptide comprising amino acids 61–77. Second, MGP enhances cell attachment and cell spreading on fibronectin. …”
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Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

“…The hallmarks of cancer are a fundamental concept which aids the development of new means to treat human cancers through the understanding of the acquisition of these hallmarks from cells. Melittin is a major peptide component of bee venom which has shown to be efficacious as an anticancer agent in preclinical and animal models. …”
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Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies by Aarat Patel, Georgia Seely, Rohit Aggarwal

“…Acthar® Gel (repository corticotropin injection [RCI]) is a melanocortin peptide that can induce steroid-dependent effects and steroid-independent effects. …”
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Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis by Sundararajan Jayaraman, Arathi Jayaraman

“…Interestingly, administration of complete Freund’s adjuvant alone or emulsified with a neuronal peptide to induce neurodegenerative disease during the prediabetic stage completely prevented the onset of diabetes regardless of the pH of the drinking water. …”
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Integrating TRPV1 Receptor Function with Capsaicin Psychophysics by Gregory Smutzer, Roni K. Devassy

“…TRPV1 receptors function as homotetramers that also respond to heat, proinflammatory substances, lipoxygenase products, resiniferatoxin, endocannabinoids, protons, and peptide toxins. Kinase-mediated phosphorylation of TRPV1 leads to increased sensitivity to both chemical and thermal stimuli. …”
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Acute One-Cigarette Smoking Decreases Ghrelin Hormone in Saliva: A Pilot Study by Yahia A. Kaabi, Mohiealdeen A. Khalifa

“…Cigarette smoking is commonly associated with weight loss and mechanisms for these weight changes are still elusive. Ghrelin is a peptide hormone that works in a neuroendocrine fashion to stimulate hunger and the desire for food intake. …”
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Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease by María José Pérez, Rodrigo A. Quintanilla

“…In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (Aβ) peptide and the neurofibrillary tangles composed of modified tau protein, which both lead to cellular damage and progressive neurodegeneration. …”
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Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication by Reetta Tuominen, MD, PhD, Virve Koljonen, MD, PhD

“…Calcitonin gene-related peptide antagonists are potent medications for severe migraine with few contraindications. …”
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Spines, Plasticity, and Cognition in Alzheimer's Model Mice by Tara Spires-Jones, Shira Knafo

“…The pathological hallmarks of Alzheimer's disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (Aβ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles—have been known for many decades, but the links between AD pathology and dementia and effective therapeutic strategies remain elusive. …”
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Pituitary adenylate cyclase-activating polypeptide plays a role in neuropsychiatric and substance use disorders: sex-specific perspective by Catherine E. Van Doorn, Mikala M. Zelows, Anel A. Jaramillo

“…The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) plays a pivotal role in regulating stress, fear, and anxiety responses. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…The cytotoxic effects of the RADC were evaluated in CLDN18.2-positive tumor cell lines and xenografts.Results: HLX58 was successfully conjugated with DXd using the cleavable maleimide GGFG peptide linker and labeled with 131I to produce RADC-131I-HLX58-Der. …”
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Comparison of GLP-1RAs vs Other Pharmacotherapy for Obesity by Andrew Overholser, Eric Czech, Linda Speer, Joel Wilson, Alex Overholser

“…The current United States Food and Drug Administration (FDA) approved pharmaceutical therapy choices for long-term use include a combination of phentermine-topiramate, combination bupropion-naltrexone, orlistat, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and dual action GLP-1RAs and gastric inhibitory peptide agonists (GIP). …”
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Effect of Ultrasonic-Assisted Thermal Treatment on the Structure and Solubility of Rapeseed Protein by ZHAO Kangyu, YANG Ping, MA Junkun, SHU Wenjing, YANG Feng, XIE Yisha, LIU Qingqing

“…After the combined ultrasonic-thermal treatment, the spatial structure of protein molecules was unfolded, thus resulting in the breaking of peptide bonds and the exposure of hydrophobic groups. …”
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Atypical Celiac Disease: From Recognizing to Managing by B. Admou, L. Essaadouni, K. Krati, K. Zaher, M. Sbihi, L. Chabaa, B. Belaabidia, A. Alaoui-Yazidi

“…The availability of high-sensitive and specific serologic tests such as antitissue transglutuminase, antiendomysium, and more recent antideamidated, gliadin peptide antibodies permits to efficiently uncover a large portion of the submerged CD iceberg, including individuals having conditions associated with a high risk of developing CD (type 1 diabetes, autoimmune diseases, Down syndrome, family history of CD, etc.), biologic abnormalities (iron deficiency anemia, abnormal transaminase levels, etc.), and extraintestinal symptoms (short stature, neuropsychiatric disorders, alopecia, dental enamel hypoplasia, recurrent aphtous stomatitis, etc.). …”
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Simulated gastrointestinal digestion of milk caseins containing A1 β-casein does not lead to increased production of inflammatory proteins in intestinal epithelial cells in vitro w... by Alan Aitchison, Teagan S. Edwards, Andrew S. Day

“…Gastrointestinal digestion of bovine milk protein β-casein releases a biologically active peptide β-casomorphin (BCM)-7, which has been associated with increased incidence of non-communicable diseases and negative effects on digestive comfort. …”
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Multifocal Insulinoma in Pancreas and Effect of Intraoperative Ultrasonography by Ersin Borazan, Alper Aytekin, Latif Yilmaz, Muhsin Elci, Mehmet Salih Karaca, Selim Kervancioglu, Ahmet Abdulhalik Balik

“…The present case was examined with the findings of hypoglycemia and hypercalcemia, and as there was high insulin and C-peptide levels the initial diagnosis was insulinoma. …”
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Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

“…The tumor microenvironment activated RiboTAC (TaRiboTAC) incorporates two pre-miR-21 binders, a near-infrared fluorophore IR780, an RGD targeting peptide and a phenylboronic acid caged ribonuclease recruiter. …”
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