Is glucose‐induced hypersecretion of glicentin after the revision surgery using Roux‐en‐Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a typ... by Yukako Yamamoto, Osamu Sekine, Jun Ito‐Kobayashi, Ayane Nishida, Takeshi Togawa, Yuki Ozamoto, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura, Masanori Iwanishi, Akira Shimatsu, Atsunori Kashiwagi

“…Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post‐LSG. …”
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Protective Actions of PPAR-γ Activation in Renal Endothelium by Peter E. Westerweel, Marianne C. Verhaar

“…PPAR-γ-receptor activation stimulates the production of nitric oxide, C-type natriuretic peptide, and superoxide dismutase, while endothelin-1 production is inhibited. …”
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Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases by Junmin Wang, Ning Ding, Chong Chen, Simin Gu, Jing Liu, Yanping Wang, Liubing Lin, Yiyuan Zheng, Yong Li

“…Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO), located chromosome 9p13.3, with a conserved amino acid sequence across humans and mice. …”
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The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments by Bruna Bombassaro, Eliana P. Araujo, Licio A. Velloso

“…This has contributed to the characterization of the mechanisms by which glucagon-like peptide-1 receptor agonists promote body mass reduction and has opened new windows of opportunity for the development of drugs to treat obesity. …”
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Potency of sponge-associated bacteria producing bioactive compounds as biological control of vibriosis on shrimp by Adityawati Fajar Rini, Munti Yuhana, Aris Tri Wahyudi

“…ABSTRACT   The aims of this study were to obtain sponge-associated bacteria as biocontrol to inhibit vibriosis in vitro and in vivo, to identify the bacterial isolates based on 16S-rRNA gene, and to detect the presence of nonribosomal peptide synthetase (NRPS), and polyketide synthase (PKS) genes to prove its ability of bioactive compounds synthesis. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Pegmolesatide (by Hansoh Pharma) is currently the only marketed long-acting EPO mimetic peptide (EMP) for the treatment of anemia in both dialysis and non-dialysis CKD patients. …”
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An innovative method used for the identification of N-glycans on soybean allergen β-conglycinin by Cheng Li, Yang Tian, Jianli Han, Yu Lu, Meiyi Zou, Yue Jia, Chengjian Wang, Linjuan Huang, Zhongfu Wang

“…It is noteworthy that the peptide VVN#ATSNL (where # represents for the glycosylation site) was analyzed to be both glycopeptide and linear epitope. …”
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Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? by Fulvia Ceccarelli, Matteo Saccucci, Gabriele Di Carlo, Ramona Lucchetti, Andrea Pilloni, Nicola Pranno, Valeria Luzzi, Guido Valesini, Antonella Polimeni

“…Moreover, the possible role of proinflammatory cytokines, such as TNF and IL6 and autoantibodies, specifically anticyclic citrullinated peptide antibodies, has been examined, suggesting the need to perform further studies to better define this issue.…”
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Molecular basis for azetidine-2-carboxylic acid biosynthesis by Tim J. Klaubert, Jonas Gellner, Charles Bernard, Juliana Effert, Carine Lombard, Ville R. I. Kaila, Helge B. Bode, Yanyan Li, Michael Groll

“…Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases. AZE synthases catalyse the intramolecular 4-exo-tet cyclisation of S-adenosylmethionine (SAM), yielding a highly strained heterocycle. …”
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Adropin as an indicator of T2DM and its complications by Hu Zhang, Ning Chen

“…Therefore, the prevention and treatment of T2DM and its complications has become an urgent problem to be solved. As a secreted peptide, adropin is identified as a useful regulator associated with insulin sensitivity and energy homeostasis. …”
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A molecular toolkit for heterologous protein secretion across Bacteroides species by Yu-Hsuan Yeh, Vince W. Kelly, Rahman Rahman Pour, Shannon J. Sirk

“…To understand the mechanistic drivers of Bacteroides secretion, we characterize signal peptide sequence features, post-secretion extracellular fate, and the size limit of protein cargo. …”
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FLAIR Hyperintense Vessel Sign of Both MCAs with Severe Heart Failure by Donghee Kim, Seung-Yul Lee, Kwon-Duk Seo

“…In the baseline routine laboratory investigations, the AST, ALT, and B-type natriuretic peptide levels were elevated. Transthoracic echocardiography (TTE) showed mitral valve prolapse with severe regurgitation. …”
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Purification, Physicochemical Properties, and Epitope Analysis of Sarcoplasmic Calcium-Binding Protein from Penaeus vannamei by CHEN Wei, ZHOU Junjun, CHEN Yachun, JIA Yingmin, MA Aijin

“…The results showed that the purified protein, which was obtained by successive steps of crude protein extraction, ammonium sulfate fractionation and anion exchange chromatography and exhibited a molecular mass of 21.6 kDa, was identified as SCP with a peptide coverage of 93.26%. SCP had strong immunoactivity, which decreased during heat treatment (≥ 65 ℃) and under strongly acidic and alkaline conditions. …”
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Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) by Yuqin Dan, Ying Xiong, Danghan Xu, Yuqi Wang, Meng Yin, Pengwei Sun, Yi Ding, Ziyun Feng, Peng Sun, Weili Xia, Gongchang Yu, Gongchang Yu, Li Li, Li Li

“…This may be closely related to the release of signaling molecules such as monoamine neurotransmitters, the glutamatergic system, the gut-microbiota-brain axis, pro-inflammatory cytokines and the endogenous opioid peptide system. However, fewer studies have mentioned the main targets of music to promote functional changes in brain regions. …”
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Pituitary adenylyl cyclase-activating polypeptide modulates the stress response: the involvement of different brain areas and microglia by Anika Singh, Paul Shim, Sadaf Naeem, Shafiqur Rahman, Kabirullah Lutfy

“…Previous research has shown that this peptide/receptor system serves as a modulator of the stress response. …”
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The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus by Thiquynhnga Nguyen, Min Gong, Song Wen, Xinlu Yuan, Chaoxun Wang, Jianlan Jin, Ligang Zhou

“…As an incretin hormone, glucagon-like peptide-1 (GLP-1) possesses multiple metabolic benefits such as optimizing energy usage, maintaining body weight, β cell preservation, and suppressing neurodegeneration. …”
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Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice by Jing Li, Xinyue Yu, Xinxing Xu, Peipei Tang, Shuang Bi, Xiaopu Ren, Yong Shi, Jihong Wu, Fei Lao

“…Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…In addition, we briefly discussed potential pharmacological interventions for glucose metabolism to alleviate MDD, including glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, and pioglitazone, to encourage the development of new therapeutics.…”
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Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse by Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

“…Upon binding of the TCR to cognate peptide-MHC complexes presented on the surface of antigen presenting cells (APCs), a specialized supramolecular structure known as the immunological synapse (IS) assembles at the T cell-APC interface. …”
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Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic by Edwin C. Jones, J. Craig Rylands, Cortney L. Jardet

“…By the age of 55, the patient no longer required any insulin and is currently being managed with metformin alone. C-peptide values indicate a functional improvement of the β-islet cells during the time of insulin/GABA/probiotic treatment.…”
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