Evaluating the Effect on Total Daily Insulin Dose in Adult Patients with Type 1 Diabetes Managed with Metformin and/or GLP-1 or GLP-1/GIP Receptor Agonists by Mayeesha Ahmed, Emily Pierson, Molly Webster

“… Purpose: There are few studies that have assessed the utility of metformin and glucagon-like peptide-1 receptor agonists (GLP-1 RA) in type 1 diabetes (T1D), specifically looking at glucose control indices. …”
Get full text

Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review by Ming Cheng, Yuan Ding, Dongmei Wang, Chunxiu Gong

“…Elevated levels of IAAs and an inappropriate insulin to C-peptide molar ratio during an extended OGTT are critical indicators. …”
Get full text

Effect of phenylbutazone administration on the enteroinsular axis in horses with insulin dysregulation by Kate L. Kemp, Jazmine E. Skinner, François‐René Bertin

“…The effects of ID status and treatment on peptide concentrations were assessed using t tests and analyses of variance. …”
Get full text

Spontaneous high clonal expansion of Wilms’ tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms’ tumor gene 1-expressing solid tumor by Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoya Hashimoto, Toshiki Yoshimine, Atsushi Kumanogoh, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

“…However, the spontaneous WT1-specific immune response before WT1 peptide vaccination in patients with WT1-expressing tumors (PTs) remains unclear. …”
Get full text

Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes by Wiktor Biesiada, Ewelina Kopczyńska, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“… Introduction Tirzepatide, a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has emerged as a transformative metabolic therapy with exceptional efficacy in weight management and glycemic control. …”
Get full text

Comparative Efficacy and Safety of Targeted Therapies for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Network Meta-Analysis by Yusi Chen, Fang Li, Jun Luo, Jingyuan Chen, Peng Luo, Jiang Li

“…Bosentan was significantly better than others with regard to reducing brain natriuretic peptide/N-terminal pro-B-type natriuretic peptide with a probability of 84.3%. …”
Get full text

In Vitro Activation and Inhibition of Recombinant EGFR Tyrosine Kinase Expressed in Escherichia coli by Jihene Elloumi-Mseddi, Karim Jellali, Sami Aifa

“…Protein expression was improved thanks to the deletion of a 13-amino acid peptide of the juxtamembrane region (JM). The recombinant proteins were produced as a glutathione S-transferase (GST) fusion in Escherichia coli, and the solubilisation was performed by sarkosyl addition during extraction. …”
Get full text

Obesity Hypertension: The Regulatory Role of Leptin by Shilpa Kshatriya, Kan Liu, Ali Salah, Tamas Szombathy, Ronald H. Freeman, Garry P. Reams, Robert M. Spear, Daniel Villarreal

“…Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. …”
Get full text

Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms by LI Yanbing, ZHOU Menglan, XU Yingchun

“…Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise. …”
Get full text

Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat by P. Jönsson, K. Ohlsson

“…Hitherto, only indirect measurements of pancreatic bradykinin formation have been performed, monitoring the peptide in the circulation and in the peritoneal exudate. …”
Get full text

Severe Transient Hyperglycemia in a Prediabetic Patient during Mild Acute Pancreatitis by Aura Diana Reghina, Silvia Craciun, Simona Fica

“…At two months from first presentation, pancreatic antibodies were negative, and the C-peptide level was normal. A1c level was 5.9% without insulin treatment. …”
Get full text

Evaluation of Preptin and other Biomarkers in Coronary Artery Disease Patients with and without Diabetes Mellitus by Saja T. Yassen, Layla O. Farhan

“… Background: Preptin is an endocrine peptide with 34 amino acids. Conjugated with insulin, it is produced by β-cells from the pro-insulin-like growth factor 2 E-peptide. …”
Get full text

Comprehensive analysis of a-and b-thalassemia genotypes and hematologic phenotypes by Heng Wang, Hai Huang, Yaping Chen, Xie Dan, Bangquan An, Shengwen Huang

“…The clinical severity is positively correlated with the imbalance of a peptide chain and b peptide chain. A comprehensive understanding of the hematologic phenotype differences between different genotypes and subtypes of thalassemia can provide more accurate data for genetic counseling of thalassemia.…”
Get full text

Targeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring by Adam R. Evans, Joseph Mulholland, Michael J. Lewis, Ping Hu

“…Peptide mapping with mass spectrometry (MS) is an important tool for protein characterization in the biopharmaceutical industry. …”
Get full text

Chemokines and Chemokine Receptors in Multiple Sclerosis by Wenjing Cheng, Guangjie Chen

“…Chemokines, which are small peptide mediators, can attract pathogenic cells to the sites of inflammation. …”
Get full text

Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells by Silvia Orisio, Marina Morigi, Carla Zoja, Norberto Perico, Giuseppe Remuzzi

“…TNF-α induced endothelin-1 gene expression was associated with a parallel increase in the release of the corresponding peptide in the culture medium. These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.…”
Get full text

Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias by Elizabeta Nemeth

“…The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution. …”
Get full text

Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity by Xiaoping Wang, Qiaoxia Wang

“…AFP-modified immune cell vaccine or peptide vaccine has displayed the specific antitumor immunity against AFP-positive tumor cells and laid a better foundation for the immunotherapy of liver cancer.…”
Get full text

Oxytocin in the Treatment of Psychiatric Disorders by Salim Cagatay KAGIZMAN, Cicek HOCAOGLU

“…Oxytocin is a peptide hormone that is most known for its role in reproduction. …”
Get full text

Solid-Phase Extraction Strategies to Surmount Body Fluid Sample Complexity in High-Throughput Mass Spectrometry-Based Proteomics by Marco R. Bladergroen, Yuri E. M. van der Burgt

“…Various sample preparation methods that involve solid-phase extraction (SPE) including affinity enrichment strategies have been automated. Obtained peptide and protein fractions can be mass analyzed by direct infusion into an electrospray ionization (ESI) source or by means of matrix-assisted laser desorption ionization (MALDI) without further need of time-consuming liquid chromatography (LC) separations.…”
Get full text