Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route by Anne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, Line Séguy, Ophélie Bento, Sophie Corvaisier, Thomas Culerier, Romain Legrand, Noëlle Callizot, Alexandre Henriques, Georgia Culley, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne

“…Finally, intranasal administration of low doses of bambuterol gel in mice intoxicated with Aβ peptides, prevented long-term spatial memory impairment and showed beneficial effects on the survival of neurons and on synapse preservation.…”
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Transient degradation of NF-κB proteins in macrophages after interaction with mast cell granules by Noriko Ito, Yuai Li, Tsuneo Suzuki, Daniel J. Stechschulte, Kottarappat N. Dileepan

“…Antibodies to N-terminal peptides of p50, p52, p65 or c-Rel supershifted only a fraction of NF-κBx. …”
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Automation-aided construction and characterization of Bacillus subtilis PrsA strains for the secretion of amylases by Felix Hamburger, Niels Schlichting, Michael Eichenlaub, Paul Igor Costea, Christopher Sauer, Stefan Jenewein, Johannes Kabisch, Johannes Kabisch

“…Among the screened constructs, the signal peptides YdjM and YvcE demonstrated the best performance.…”
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Multifunctional Proteins Bridge Mitosis with Motility and Cancer with Inflammation and Arthritis by Jihong Jiang, Rosaely Casalegno-Garduno, Helen Chen, Anita Schmitt, Michael Schmitt, Christopher A. Maxwell

“…While most secreted proteins contain defined signal peptides that direct their extracellular transport through the ER-Golgi pathway, nonclassical transport of leaderless peptides/proteins was first described 20 years ago and the mechanisms responsible for unconventional export of such proteins have been thoroughly reviewed. …”
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The Role of Macrophages in the Pathogenesis of Celiac Disease by A. I. Khavkin, E. V. Loshkova, E. I. Kondratieva, N. S. Shapovalova, I. R. Grishkevich, I. V. Doroshenko, G. N. Yankina

“…Celiac disease is an autoimmune disease with a characteristic serological (antibodies to tissue transglutaminase, endomysium, deamidated gliadin peptides) and histological profile (inflammatory infiltration of the villous epithelium by lymphocytes and their atrophy, crypt hyperplasia) caused by gluten consumption in genetically predisposed individuals. …”
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Generation of Mature Nα-Terminal Acetylated Thymosin α1 by Cleavage of Recombinant Prothymosin α by Bo Liu, Xin Gong, Shaohong Chang, Peng Sun, Jun Wu

“…Nα-terminal acetylation of peptides plays an important biological role but is rarely observed in prokaryotes. …”
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Spectroscopic and Theoretical Studies of Hg(II) Complexation with Some Dicysteinyl Tetrapeptides by Elliot Springfield, Alana Willis, John Merle, Johanna Mazlo, Maria Ngu-Schwemlein

“…These structural insights on peripheral mercury-peptide interactions provide additional understanding of the chemistry of mercury(II) with side-chain donor groups in peptides.…”
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Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients wit... by Charissa Wijnands, Peter G. A. Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta, Corrie M. de Kat Angelino, Luciano Di Stefano, Vincent Bonifay, Theo M. Luider, Martijn M. VanDuijn, Sandra J. Croockewit, Elizabeth A. de Kort, Daan A. R. Castelijn, Claudia A. M. Stege, Hans J. C. T. Wessels, Alain J. van Gool, Niels W. C. J. van de Donk, Joannes F. M. Jacobs

“…Ig constant regions were monitored using isotype-specific peptides. <b>Results:</b> The MS-MRD multiplex analysis provided detailed information on drug concentrations and therapy response kinetics. …”
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Protein hydrolysate as an efficient and environmental-friendly swelling inhibitor in clay formations by Yahya Dashti-Rahmatabadi, Hamid Saeidian, Javad Mokhtari, Zohreh Mirjafary

“…The HPC formulation consists of amino acids, peptides, and polypeptides with molecular weights ranging from 100 to 10,000 Dalton. …”
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<i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome by Emer Shannon, Maria Hayes

“…Seaweeds are a rich source of bioactives consisting of proteins/peptides, polysaccharides, and lipids. This study examined the potential of seaweed-derived bioactives from <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as inhibitors of ACE-1, α-amylase, and lipase. …”
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Cultivated genome references for protein database construction and high-resolution taxonomic annotation in metaproteomics by Xiaowei Gao, Hewei Liang, Tongyuan Hu, Yuanqiang Zou, Liang Xiao

“…The selection of an appropriate database is a critical step for the identification of peptides and proteins, as well as for the provision of accurate taxonomic and functional annotations. …”
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Effects of IQW and IRW on Inflammation and Gut Microbiota in ETEC-Induced Diarrhea by Naiyuan Liu, Lingsi Zhou, Jun Fang, Hongmei Jiang, Gang Liu

“…Changing gut microbiota is one of the most common causes of host gut inflammation. The active triple peptides, lle-Gln-Trp (IQW) and lle-Arg-Trp (IRW), cause remarkable changes to gut microbiota. …”
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Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by A. N. Chikaev, A. P. Rudometov, Yu. A. Merkulyeva, L. I. Karpenko

“…Each phage particle in a library displays peptides or proteins fused to its coat protein and simultaneously carries the DNA sequence encoding the displayed peptide/protein in its genome. …”
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Polymorphism of CLE gene sequences in potato by M. S. Gancheva, M. R. Losev, A. A. Gurina, L. O. Poliushkevich, I. E. Dodueva, L. A. Lutova

“…In this regard, the identification and study of the CLE genes encoding the peptides of this group in cultivated plants are of great practical interest. …”
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Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches by Yifan Lu, Yifan Lu, Tiao Li, Yang Shu, Yang Shu, Chengyin Lu, Chengyin Lu, Zhiqiang Luo, Zhiqiang Luo, Jingrui Wang, Jingrui Wang, Hui Xiong, Wangyang Li, Wangyang Li

“…In addition, we discuss the protective role of antioxidant factors such as GPX4 (glutathione peroxidase 4) and antioxidant peptides like SS peptides in mitigating lipid peroxidation and delaying the progression of sarcopenia. …”
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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…Equally problematic is that no sensitive unique tryptic peptides suitable for quantitative mass spectrometric analysis could be identified in the mIgG2a complementarity-determining regions. …”
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Small Bowel Review - Part I by ABR Thomson, G Wild

“…Part I of this two-part review of the small bowel examines carbohydrates, including brush border membrane hydrolysis and sugar transport; amino acids, dipeptides, proteins and food allergy, with a focus on glutamine, peptides and macromolecules, and nucleosides, nucleotides and polyamines; salt and water absorption, and diarrhea, including antidiarrheal therapy and oral rehydration treatment; lipids (digestion and absorption, fatty acid binding proteins, intracellular metabolism, lipoproteins and bile acids); and metals (eg, iron) and vitamins.…”
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Protonation Equilibria of Biologically Active Ligands in Mixed Aqueous Organic Solvents by Ahmed A. El-Sherif, Mohamed M. Shoukry, Abeer T. Abd Elkarim, Mohammad H. Barakat

“…The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…We focus on recombinant vaccine antigens comprising fusion proteins consisting of combinations of SARS-CoV-2-derived antigens or peptides or combinations of SARS-CoV-2 antigens/peptides with SARS-CoV-2-unrelated proteins/peptides. …”
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Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…The natural antimicrobial peptides are ancient host defense effector molecules, present in organisms across the evolutionary spectrum. …”
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