INTERRELATION OF PRIONS WITH NON-CODING RNAS by R. N. Mustafin, E. K. Khusnutdinova

“…MicroRNAs and long non-coding RNAs can be translated into functional peptides. These peptides can have a regulatory effect on genes from which their non-coding RNAs are transcribed. …”
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Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes by Tiina Jauhiainen, Taru Pilvi, Zhong Jian Cheng, Hannu Kautiainen, Dominik N. Müller, Heikki Vapaatalo, Riitta Korpela, Eero Mervaala

“…Fermented milk, but not peptides in water, attenuated the development of hypertension in dTGR by 19 mmHg versus the control group (P=.023). …”
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Ratio Imaging of Enzyme Activity Using Dual Wavelength Optical Reporters by Moritz F. Kircher, Lee Josephson, Ralph Weissleder

“…One probe consists of the NIRF dye Cy5.5 attached to a particulate carrier, a crosslinked iron oxide nanoparticle (CLIO), through cathepsin B cleavable l -arginyl peptides. A second probe consists of Cy3.5 attached to a CLIO through proteolytically resistant d -arginyl peptides. …”
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Antiproteinase 3 Positive Eosinophilic Granulomatosis with Polyangiitis Presenting with Heart Failure and Intraventricular Thrombosis by Dan Zhu, Yiming Luo, Xiangyuan Liu, Lingyun Zu

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Protonation Equilibria of Biologically Active Ligands in Mixed Aqueous Organic Solvents by Ahmed A. El-Sherif, Mohamed M. Shoukry, Abeer T. Abd Elkarim, Mohammad H. Barakat

“…The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. …”
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Immune response profiling of HERV-W envelope proteins in multiple sclerosis: potential biomarkers for disease progression by Stefano Ruberto, Stefano Ruberto, María I. Domınguez-Mozo, M. Angel Garcıa-Martınez, Davide Cossu, Davide Cossu, Leonardo A. Sechi, Leonardo A. Sechi, Roberto Alvarez-Lafuente

“…This study aims to evaluate both humoral and cell-mediated immune response to antigenic peptides derived from these proteins across different clinical forms and inflammatory phases of MS.MethodsIndirect enzyme-linked immunosorbent assay (ELISA) was employed to measure immunoglobulin G (IgG) responses to syncytin-1env 486-500 and pHERV-Wenv 486-504 peptides in MS patients. …”
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Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients wit... by Charissa Wijnands, Peter G. A. Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta, Corrie M. de Kat Angelino, Luciano Di Stefano, Vincent Bonifay, Theo M. Luider, Martijn M. VanDuijn, Sandra J. Croockewit, Elizabeth A. de Kort, Daan A. R. Castelijn, Claudia A. M. Stege, Hans J. C. T. Wessels, Alain J. van Gool, Niels W. C. J. van de Donk, Joannes F. M. Jacobs

“…Ig constant regions were monitored using isotype-specific peptides. <b>Results:</b> The MS-MRD multiplex analysis provided detailed information on drug concentrations and therapy response kinetics. …”
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Effects of autolytical fish protein hydrolysate on growth performance, survival rate, and hematological indices in farmed juvenile beluga, Huso huso by Ali Hosseinpour Zelaty

“…FPHs contain functional and bioactive peptides, making them a viable substitute for fishmeal in aquafeeds. …”
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Unlocking the potential of collagen: A comprehensive review on its dermocosmetic benefits and applications by Felicia Andrei, Ana Toma, Ștefania Avram, Valentin Popa, Ioana Gencia, Patricia Cristodor

“…The study aimed to assess collagen’s efficacy and safety in dermocosmetology, comparing collagen peptides’ effectiveness in oral and topical applications. …”
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Comparison of ZnS(Ag) Scintillator and Proportional Counter Tube for Alpha Detection in Thin-Layer Chromatography by Marc Pretze, Jan Wendrich, Holger Hartmann, Robert Freudenberg, Ralph A. Bundschuh, Jörg Kotzerke, Enrico Michler

“…For ²¹²Pb-labelled peptides, the probe sampling did not have a high impact on the value of the RCP for the MiniScanPRO+ and AR-2000. …”
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A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics by Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

“…Reactivity to at least one of the SHBsAg peptides was found in 8 (14%) pre-HBvacc subjects; amongst the remaining 50, reactivity to at least one of the SHBsAg peptides appeared in 47 (94%) post-HBvacc. …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…We focus on recombinant vaccine antigens comprising fusion proteins consisting of combinations of SARS-CoV-2-derived antigens or peptides or combinations of SARS-CoV-2 antigens/peptides with SARS-CoV-2-unrelated proteins/peptides. …”
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A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection by Ping Li, Ping Li, Ziyi Jiang, Jingjing Shi, Haochuan Sha, Zihang Yu, Yan Zhao, Sanyang Han, Lan Ma, Lan Ma, Lan Ma

“…These epitope peptides detected a binding capability with host cells were then fused by flexibility linkers and expressed in Escherichia coli to reduce the unnecessary glycan modifications to simulate their free-glycan status. …”
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Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route by Anne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, Line Séguy, Ophélie Bento, Sophie Corvaisier, Thomas Culerier, Romain Legrand, Noëlle Callizot, Alexandre Henriques, Georgia Culley, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne

“…Finally, intranasal administration of low doses of bambuterol gel in mice intoxicated with Aβ peptides, prevented long-term spatial memory impairment and showed beneficial effects on the survival of neurons and on synapse preservation.…”
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freeQuant: A Mass Spectrometry Label-Free Quantification Software Tool for Complex Proteome Analysis by Ning Deng, Zhenye Li, Chao Pan, Huilong Duan

“…In this paper, we present a mass spectrometry label-free quantification tool for complex proteomes, called freeQuant, which integrated quantification with functional analysis effectively. freeQuant consists of two well-integrated modules: label-free quantification and functional analysis with biomedical knowledge. freeQuant supports label-free quantitative analysis which makes full use of tandem mass spectrometry (MS/MS) spectral count, protein sequence length, shared peptides, and ion intensity. It adopts spectral count for quantitative analysis and builds a new method for shared peptides to accurately evaluate abundance of isoforms. …”
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Comparative Exploration of Antioxidant Properties of Alcalase- and Trypsin-Hydrolyzed Porcine By-Products and Their Classification for Industrial Use by Jun Hwang, Woo-Young Son, Eun Ju Jeong, Kyeong-Soo Kim, Eui-Cheol Shin, Dong-Heon Song, Kyung-Woo Lee, Hyun-Wook Kim

“…Porcine by-products have garnered attention as an excellent material for producing antioxidant peptides; however, understanding the antioxidant characteristics of protein hydrolyzates derived from specific parts remains limited. …”
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Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect by Takuto Nakamura, Masanobu Yamazato, Akio Ishida, Yusuke Ohya

“…Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides. In the brain, it activates the renin angiotensin system and causes hypertension. …”
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Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells by A. Jiménez-Periáñez, B. Abos Gracia, J. López Relaño, C. M. Diez-Rivero, P. A. Reche, E. Martínez-Naves, E. Matveyeva, M. Gómez del Moral

“…We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.…”
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Challenges and applications of artificial intelligence in infectious diseases and antimicrobial resistance by Angela Cesaro, Samuel C. Hoffman, Payel Das, Cesar de la Fuente-Nunez

“…These tools improve antibiotic stewardship and identify effective compounds such as antimicrobial peptides and small molecules. This review explores AI applications in diagnostics, therapy, and drug discovery, emphasizing both strengths and areas needing improvement.…”
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Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins by Rodriguez Palomo, Ismael, Nair, Bharath, Chiang, Yun, Dekker, Joannes, Dartigues, Benjamin, Mackie, Meaghan, Evans, Miranda, Macleod, Ruairidh, Olsen, Jesper V., Collins, Matthew J.

“…However, there is a lack of a systematic exploration of how these affect the identification of peptides, post-translational modifications (PTMs), proteins and their significance (through the False Discovery Rate) and correctness. …”
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