A Review of Marine Bacterial Intracellular and Extracellular Bioactive Compounds as Novel Antibacterial and Anti-Inflammation Agents by Harningsih Karim, Arief Azis, Ananda Ramadani, Anita Anita, Ahyar Ahmad, Hasnah Natsir, Paulina Taba, Suriati Eka Putri, Sarlan Sarlan, Siti Halimah Larekeng, Rizal Irfandi

“…A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. …”
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The Interplay between Defensins and Microbiota in Crohn’s Disease by Lorena Coretti, Alessandro Natale, Mariella Cuomo, Ermanno Florio, Simona Keller, Francesca Lembo, Lorenzo Chiariotti, Raffaela Pero

“…Several studies have shown defective expression of intestinal antimicrobial peptides (AMPs) in patients with CD compared to controls, particularly defensins. …”
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Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes by Zijun Ma, Kaiqin Jin, Mengmeng Yue, Xin Chen, Jun Chen

“…In addition, the very concept of synthetic peptides opens up many unknown possibilities for tirzepatide. …”
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Anti-CCP: History and its Usefulness by M. Herold, V. Boeser, E. Russe, W. Klotz

“…Antibodies directed to cyclic citrullinated peptides (anti-CCP) are highly specific for rheumatoid arthritis (RA) and can easily be detected in sera by using commercially available immunoassays. …”
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Targeting Drug Delivery to the Lungs by Inhalation by C. O'Callaghan

“…This route of administration may be particularly attractive if it avoids the metabolic destruction encountered when some drugs are administered by alternative routes (for instance, peptides and proteins are rapidly destroyed by peptidases when Oven by the oral route). …”
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D-Amino Acids in the Nervous and Endocrine Systems by Yoshimitsu Kiriyama, Hiromi Nochi

“…Amino acids are important components for peptides and proteins and act as signal transmitters. …”
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Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis by Yosuke Seto, Koichiro Tamura

“…In response to the fungal infection, a transcriptome profile of immune-related genes was considerably different between D. melanogaster and D. virilis: the genes encoding antifungal peptides, Drosomycin and Metchnikowin, were highly expressed in D. melanogaster whereas, the genes encoding Diptericin and Defensin were highly expressed in D. virilis. …”
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A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System by Mario García-Domínguez

“…One explanation for the emergence of disrupted pain modulation in individuals with fibromyalgia is a significant reduction in opioid receptor activity or an imbalance in the levels of endogenous opioid peptides. Further research is essential to clarify the complex details of the mechanisms underlying this abnormality. …”
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Drosophila Cul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense by Fanrui Kong, Zixuan Wang, Chuchu Zhang, Yihua Xiao, Muhammad Abdul Rehman Saeed, Weini Li, Akira Goto, Qingshuang Cai, Shanming Ji

“…We show that silencing of Cul3 leads to a decreased induction of antimicrobial peptides and high mortality in adult flies after bacterial infection. …”
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Constitutive Expression of Functionally Active Protease-Activated Receptors 1 and 2 in Human Conjunctival Epithelial Cells by Timothy J. Nickel, Mohammad H. Kabir, Jaya Talreja, Daniel J. Stechschulte, Kottarappat N. Dileepan

“…The results show that HCECs constitutively express PAR1 and PAR2 mRNA and proteins, and produce significant amounts of IL-6 when incubated with specific PAR-activating enzymes or agonist peptides. Thrombin- and tryptase-induced HCEC activation was blocked by PAR1 and PAR2 neutralizing antibodies, respectively, and by specific enzyme inhibitors. …”
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Research Progress of Bacteriocin Combined with Physical Technology in the Prevention and Control of Foodborne Pathogens and Spoilage Microorganisms by Mingzhu WANG, Zihao TIAN, Zhongmei TAN, Jie REN, Gaoyun WU, Jinqi GUO, Yuchang YAO, Yuan YIN, Bailiang LI, Jiage MA, Wei YU

“…Bacteriocins are antimicrobial peptides synthesized by some bacterial ribosomes and are widely used as bio-preservatives and food additives. …”
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PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes by Hyun-keun Kim, Seonung Lim, Min-Jung Bae, Wonwoo Lee, Sunyoung Kim

“…It was found that knockdown of IL37 resulted in the augmented expression of antimicrobial peptides (AMPs) in response to cytokine stimulation. …”
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Efficient reduction of β-lactoglobulin allergenicity in milk using Clostridium tyrobutyricum Z816 by Qianru Zhao, Yuwei Wang, Zhengming Zhu, Quanyu Zhao, Liying Zhu, Ling Jiang

“…Clostridium tyrobutyricum Z816 was selected for the degradation of β-LG, which was successfully reduced by about 90 % using permeabilized bacteria under the optimized conditions. The hydrolyzed peptides were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and analyzed by molecular modeling, which indicated that C. tyrobutyricum Z816 could effectively degrade the antigenic epitopes of β-LG. …”
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Arabidopsis conditional photosynthesis mutants abc1k1 and var2 accumulate partially processed thylakoid preproteins and are defective in chloroplast biogenesis by Joy Collombat, Manfredo Quadroni, Véronique Douet, Rosa Pipitone, Fiamma Longoni, Felix Kessler

“…They are synthesized in the cytoplasm with cleavable targeting sequences and the lumenal ones have bi-partite targeting sequences (first for the chloroplast envelope, second for the thylakoid membrane). Cleavage of these peptides is required to establish photosynthesis and a critical step of chloroplast biogenesis. …”
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Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery by Veronica Torresan, Alessandro Gandin, Paolo Contessotto, Francesca Zanconato, Giovanna Brusatin

“…We designed a system based on hyaluronic acid, crosslinked via click-reaction with multi-arm polyethyleneglycol and functionalized with RGD peptides. Additionally, we incorporated thiol-modified heparin into the formulation, which provides specific binding sites for cytokines. …”
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Vitamin D in Early Childhood and the Effect on Immunity to Mycobacterium tuberculosis by Anna Jane Battersby, Beate Kampmann, Sarah Burl

“…Recent studies have begun to explain the mechanisms by which vitamin D affects immunity. Antimicrobial peptides are induced in conjunction with stimulation of innate pattern recognition receptors enhancing immunity to particular infections. …”
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Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae) by Juliana Rocha da Silva, Aline Zanotelli de Souza, Carlos Priminho Pirovani, Helena Costa, Aline Silva, João Carlos Teixeira Dias, Jacques Hubert Charles Delabie, Renato Fontana

“…., proteins such as phospholipases, hyaluronidases, and proteinases, as well as peptides. Protein databases show that information on protein components of ant venoms has been recently growing exponentially. …”
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Recent Advances in Biosensors Using Enzyme-Stabilized Gold Nanoclusters by Myeong-Jun Lee, Jeong-Hyeop Shin, Seung-Hun Jung, Byung-Keun Oh

“…However, because they are unstable in solution, AuNCs require stabilization by using ligands such as dendrimers, peptides, DNA, and proteins. As a result, the properties of AuNCs and their formation are determined by the ligand, so the selection of the ligand is important. …”
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Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease by Nunzia Maisto, Dalila Mango

“…However, several compounds, administered parenterally and orally, are unable to reach the brain due to the presence of the blood-brain barrier (BBB) which prevents the passage of external substances, such as proteins, peptides, or phytocompounds, representing a limit to the development of treatment for neurodegenerative diseases, such as AD. …”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…We further show that fluorescein-conjugated extracellular matrix (ECM)-binding peptides can be used to regulate SynNotch activity depending on the folding state of collagen-based ECM networks. …”
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