Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells by E. Oliveira, R. C. Assunção-Silva, O. Ziv-Polat, E. D. Gomes, F. G. Teixeira, N. A. Silva, A. Shahar, A. J. Salgado

“…The efficacy of three natural hydrogels, gellan gum (functionalized with a fibronectin peptide), collagen, and a hydrogel rich in laminin epitopes (NVR-gel) in promoting neuritogenesis (alone and cocultured with ASCs), was evaluated in the present study. …”
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Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis by Fatemeh Khodadust, Eva M. L. Philippon, Maarten M. Steinz, Jan Piet van Hamburg, Johan van Meerloo, Judy R. van Beijnum, Gerrit Jansen, Sander W. Tas, Conny J. van der Laken

“…This study evaluated potential anti-angiogenic effects of several compounds including small-molecule kinase inhibitors, such as sunitinib (pan-kinase inhibitor), tofacitinib (JAK-inhibitor), NIKi (NF-κB-inducing kinase inhibitor), and the integrin-targeting peptide fluciclatide, using a scratch assay and 3D spheroid-based models of angiogenesis. …”
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Endophytic strategies decoded by genome and transcriptome analysis of Fusarium nematophilum strain NQ8GII4 by Siyuan Yan, Qingchen Zhang, Shuxin Jia, Miaomiao Guo, Qiangqiang Zhang, Peiwen Gu, Peiwen Gu

“…Moreover, genes involved in secondary metabolite biosynthesis, such as type I polyketide synthases (T1PKS) and non-ribosomal peptide synthetases (NRPSs), were significantly downregulated. …”
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Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential by Tohada M. AL-Noshokaty, Rehab Abdelhamid, Nourhan M. Abdelmaksoud, Aya Khaled, Mariam Hossam, Razan Ahmed, Toka Saber, Shahd Khaled, Shereen Saeid Elshaer, Ahmed I. Abulsoud

“…Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. …”
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Pulmonary Embolism in the Elderly: From Symptoms to Speckle Tracking Echocardiography by Christos Ballas, Dimitrios Sfairopoulos, Ioanna Samara, Lampros Lakkas, Olga Kardakari, Athanasios Konstantinidis, Katerina K. Naka, Lampros K. Michalis, Christos S. Katsouras

“…The elderly had higher values of D-dimer, high-sensitivity troponin I and brain natriuretic peptide (BNP). Echocardiographic differences were noted and the elderly had lower values of pulmonary vascular acceleration time, RV E/A ratio and lower tricuspid annular plane systolic excursion/pulmonary artery systolic pressure ratio. …”
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Establishment of a Nomogram for Predicting Early Death in Viral Myocarditis by Xuejun Sun, Naxin Xie, Mengling Guo, Xuelian Qiu, Hongwei Chen, Haibo Liu, Hongmu Li

“…Combined with the actual clinical situation, the heart failure (HF) (OR: 2.13, 95% CI: 2.76–5.95), electrocardiogram (ECG) (OR: 6.11, 95% CI: 1.05–8.66), pneumonia (OR: 3.62, 95% CI: 1.43–9.85), brain natriuretic peptide (BNP) (OR: 4.66, 95% CI: 3.07–24.06), and lactate dehydrogenase (LDH) (OR: 1.90, 95% CI: 0.19–9.39) were finally used to construct the nomogram. …”
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Transcriptomic analysis reveals the crucial role of YABBY genes family in hormonal induced parthenocarpy in Cucumis sativus L. by Tingting Liu, Rahat Sharif, Zetao Shi, Kehong Guo, Zhisen Zhang, Xueping Bao, Ahmad Ali

“…The expression pattern of YABBY genes throughout fruit development and performed a genomic census of cucumber (Cucumis sativus L.). Based on peptide classification, we discovered eight CsYABBY genes and divided them into five subfamilies. …”
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Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data by Nair, Bharath, Palomo, Ismael Rodríguez, Markussen, Bo, Wiuf, Carsten, Fiddyment, Sarah, Collins, Matthew James

“…During liming, collagen peptides containing Glutamine (Q) undergo deamidation resulting in a mass shift of 0.984 Da. …”
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The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class? by Ricardo Godinho, Cristina Mega, Edite Teixeira-de-Lemos, Eugénia Carvalho, Frederico Teixeira, Rosa Fernandes, Flávio Reis

“…Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) increase glucagon-like peptide-1 (GLP-1) availability and correct the “incretin defect” seen in T2DM patients. …”
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Proteomic analysis reveals the roles of silicon in mitigating glyphosate-induced toxicity in Brassica napus L. by Probir Kumar Mittra, Md Atikur Rahman, Swapan Kumar Roy, Soo-Jeong Kwon, Abhik Mojumdar, Sung Ho Yun, Kun Cho, Seong-Woo Cho, Meiliang Zhou, Tomoyuki Katsube-Tanaka, Sun-Hee Woo

“…Protein-protein interactome analyses confirmed the involvement of six key proteins, including L-ascorbate peroxidase, superoxide dismutase, glutaredoxin-C2, peroxidase, glutathione peroxidase (GPX) 2, and peptide methionine sulfoxide reductase A3 which involved in antioxidant activity, sulfur assimilation, and herbicide tolerance, contributing to the resilience of B. napus against Gly toxicity. …”
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Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes by Beatriz Tavira, Hugo Barcenilla, Jeannette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Rosaura Casas

“…GAD-alum given into lymph nodes to type 1 diabetes patients participating in an open-label pilot trial resulted in preservation of C-peptide similar to promising results from other trials. …”
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Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors by Paola Di Giacinto, Francesca Rota, Laura Rizza, Davide Campana, Andrea Isidori, Andrea Lania, Andrea Lenzi, Paolo Zuppi, Roberto Baldelli

“…The symptoms associated with carcinoid syndrome and vasoactive intestinal peptide tumors are treated with octreotide acetate. …”
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Transient Neonatal Diabetes Mellitus with the Rare Association of Nonsuppurative Sialadenitis and Genetic Defects in 6q24 by Manal Mustafa, Nitin Ramdas, Mahmoud Elhalik, Arif Faquih

“…Blood tests revealed low serum insulin and C-peptide levels. Genetic analysis revealed multiple loci hypomethylation of the PLAGL1/HYMAI-DMR in the TNDM region in chromosome 6q24 and two pathogenic heterozygous variants in the ZFP57 gene. …”
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Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling by Jun Wang, Yongzheng Liu, Changhui Ma, Yue Zhang, Meng Yuan, Guangping Li

“…This study is aimed at investigating the impact of the glucagon-like peptide-1 (GLP-1) receptor agonist, Liraglutide (Lir), on atrial remodeling (AR) mouse model induced by chronic intermittent hypoxia (CIH). …”
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Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy by Rachael A. Potter, Ida H. Moeller, Sohrab Khan, Hélène Haegel, Andreas Hollenstein, Guido Steiner, Christoph Wandel, Alexander P. Murphy, Damon R. Asher, Emanuel Palatinsky, Danielle A. Griffin, Stefanie Mason, Susan T. Iannaccone, Craig M. Zaidman, Louise R. Rodino-Klapac

“…In silico epitope mapping based on the patients’ HLA-I alleles indicated greater probability for peptides derived from exons 8 and/or 9 to bind HLA-I, providing further evidence that peptides derived from corresponding micro-dystrophin regions may have higher immunogenic potential. …”
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Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure by Miriam Bernecker, Anna Lin, Annette Feuchtinger, Anna Molenaar, Sonja C. Schriever, Paul T. Pfluger

“…HFD-induced dysregulation in hypothalamic expression of orexigenic peptides and synaptic plasticity markers persisted also after weight normalization suggesting long-lasting neural alterations. …”
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An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and onli... by Teresa Kwok, She Lin Chan, Mike Zhou, Tong Chen, Niusheng Xu, Victor Li, Tiemin Huang, Tao Bo

“…This protocol enables both intact MS-based protein charge variant characterization and in-depth peptide mapping of collected fractions via high-performance liquid chromatography (HPLC) tandem mass spectrometry. …”
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Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats by Jázmin Ayman, András Buzás, Roberta Dochnal, Miklós Palotai, Miklós Jászberényi, Zsolt Bagosi

“…<b>Background/Objectives:</b> Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. …”
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Long-term effects of duodenal mucosal resurfacing and liraglutide on glycaemic control in patients with type 2 diabetes by Max Nieuwdorp, Annieke C G van Baar, Jacques J G H M Bergman, Celine B E Busch, Julia Rubingh

“…The INSPIRE study (n=16) aimed to eliminate insulin by combining DMR with a glucagon-like peptide-1 receptor agonist (GLP-1RA). At 18 months, 53% of patients were off insulin with adequate glycaemic control. …”
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Polymorphism of CLE gene sequences in potato by M. S. Gancheva, M. R. Losev, A. A. Gurina, L. O. Poliushkevich, I. E. Dodueva, L. A. Lutova

“…In this regard, the identification and study of the CLE genes encoding the peptides of this group in cultivated plants are of great practical interest. …”
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