Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology by Francisco Hernández‐Fernández, Isabel Martínez‐Fernández, Rosa Barbella‐Aponte, Inmaculada Feria Vilar, Oscar Ayo‐Martín, Jorge García‐García, Rosa Collado, Alberto Andrés, Mar Hernández‐Guillamón, Francisco José Pena Pardo, Cristina Barrena, Miguel de laFuente, Gemma Serrano‐Heras, María Melero, Elena Lozano Setién, Luis López, Tomás Segura

“…Abstract Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta‐amyloid peptide (Aβ), has a prion‐like transmission mechanism. …”
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Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine by Joseph Bruton, Tomáš Hanke

“…In the RhCMV68-1-protected rhesus macaques, MHC-E molecules and their peptide cargo utilise complex regulatory mechanisms and unique transport patterns, and researchers study these to guide human vaccine development. …”
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Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. by Athos Silva De Oliveira, Leroy Versteeg, Neima Briggs, Rakesh Adhikari, Maria Jose Villar, JeAnna R Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

“…<h4>Conclusions/significance</h4>These findings emphasize the importance of antigen localization in tailoring immune responses and suggest that extracellular antigens are more effective for inducing humoral responses, whereas cytosolic antigen accumulation enhances MHC-1 peptide presentation. Future studies will determine if these in vitro and immunogenicity findings translate to in vivo efficacy. …”
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Controllable intein splicing and N-terminal cleavage at mesophilic temperatures by Taylor A. McNeal, Joel Weinberger, Geraldy L. S. Liman, Tia M. Ariagno, David W. Wood, Thomas J. Santangelo, Christopher W. Lennon

“…The ability of inteins to specifically rearrange peptide bonds has proven exceptionally useful in protein engineering, thus, methods to control intein activity are of considerable interest. …”
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US7 score in the subacute phase does not correlate with outcomes in Chikungunya arthritis by Benzeeta Pinto, Anu Mohan Desai, Farha Furruqh, K N Sangeeta, B Sheba Charles, John Michael Raj, Ramya Janardana, Vineeta Shobha

“…Most (22/23) patients had polyarticular disease with negative rheumatoid factor and anticyclic citrullinated peptide. Ultrasound revealed synovitis in all and tenosynovitis in most patients. …”
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α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia by Lia-Raluca Olari, Sichen Liu, Franziska Arnold, Julia Kühlwein, Marta Gil Miró, Ajeet Rijal Updahaya, Christina Stürzel, Dietmar Rudolf Thal, Paul Walther, Konstantin M. J. Sparrer, Karin M. Danzer, Jan Münch, Frank Kirchhoff

“…Additionally, an HIV-1 Env-derived amyloidogenic peptide accelerated amyloid formation by α-synuclein and Aβ peptides. …”
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Profiling endogenous airway proteases and antiproteases and modeling proteolytic activation of Influenza HA using in vitro and ex vivo human airway surface liquid samples. by Stephanie A Brocke, Boris Reidel, Camille Ehre, Meghan E Rebuli, Carole Robinette, Kevin D Schichlein, Christian A Brooks, Ilona Jaspers

“…Secondly, we present an optimized method for probing the proteolytic environment of airway surface liquid samples (in vitro and ex vivo) using fluorogenic peptides modeling the cleavage sites of respiratory viruses. …”
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Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients by Takwa Al Koloob Ali Chachan, Huda Farhan, Shatha Hamed

“… Evidence suggests that Irisin, a peptide hormone, may play a role in lipid metabolism, insulin resistance, and obesity. …”
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Functional capacity testing in patients with pulmonary hypertension (PH) using the one-minute sit-to-stand test (1-min STST). by Christina Kronberger, Roya Anahita Mousavi, Begüm Öztürk, Robin Willixhofer, Theresa-Marie Dachs, René Rettl, Luciana Camuz-Ligios, Nima Rassoulpour, Christoph Krall, Brigitte Litschauer, Roza Badr Eslam

“…N-terminal pro brain-type natriuretic peptide (NT-proBNP), WHO functional class (WHO-FC) and mean pulmonary artery pressure (mPAP) were defined as markers of PH severity.…”
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The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure. The Alzheimer's Aβ peptide and human amylin (h-amylin), the polypeptide responsible for amyloid formation in type-2 diabetes, share common physio-chemical features and some inhibitors of Aβ also inhibit amyloid formation by h-amylin and vice versa. …”
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An innovative method used for the identification of N-glycans on soybean allergen β-conglycinin by Cheng Li, Yang Tian, Jianli Han, Yu Lu, Meiyi Zou, Yue Jia, Chengjian Wang, Linjuan Huang, Zhongfu Wang

“…It is noteworthy that the peptide VVN#ATSNL (where # represents for the glycosylation site) was analyzed to be both glycopeptide and linear epitope. …”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…Soy glycinin derived octapeptide (SGP8) is a peptide obtained from degradation of the soy glycinin, whose amino acid sequence is IAVPGEVA. …”
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Effect of Exercise Rehabilitation Training on Humoral Factors in Patients with Chronic Heart Failure and its Effect Observation by Yi DING, Chenchen GUO, Jinglong SUN, Wanhong WANG, Wangjun HOU, He ZHUANG

“…Objective:To examine the effects of exercise rehabilitation training on chronic heart failure (CHF) and superoxide dismutase (SOD), homocysteine (Hcy), angiotensinⅡ(AngⅡ), lactic acid (LA) and the effect of brain natriuretic peptide (BNP), providing evidence-based medical evidence for the clinical treatment of CHF.Methods:A total of 76 patients with CHF were divided into control group and combination group, with 38 patients in each group, using the random number table method. …”
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A Chinese Family with Familial Dysalbuminemic Hyperthyroxinemia (FDH) due to R242H Mutation on Human Albumin Gene: Reevaluating the Role of FDH in Patients with Asymptomatic Hypert... by Hongbing Liu, Jianmin Ran, Chuping Chen, Guangshu Chen, Ping Zhu, Rongshao Tan, Yan Liu

“…This is an established mutation named as R218H if present without signal peptide sequence. Conclusions. For patients with asymptomatic hyperthyroxinemia, FDH should be clinically excluded before embarking on further investigations for other specific causes.…”
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Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway by Peng Yu, Xi Xu, Jing Zhang, Xuan Xia, Fen Xu, Jianping Weng, Xiaoyang Lai, Yunfeng Shen

“…A glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide (LR) had been experimentally and clinically shown to ameliorate nonalcoholic fatty liver disease (NAFLD). …”
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Determinants and Characteristics of Insulin Dose Requirements in Children and Adolescents with New-Onset Type 1 Diabetes: Insights from the INSENODIAB Study by Maude Beckers, Olivier Polle, Paola Gallo, Noémie Bernard, Céline Bugli, Philippe A. Lysy

“…Notably, no significant correlation was observed between TIDD at diagnosis and partial remission markers (IDAA1C, C-peptide) at 3- and 12-months postdiagnosis time points. …”
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FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia by Anne Morice, Amélie de La Seiglière, Alexia Kany, Roman H. Khonsari, Morad Bensidhoum, Maria-Emilia Puig-Lombardi, Laurence Legeai Mallet

“…Lastly, we found that treatment with a tyrosine kinase inhibitor (BGJ398, infigratinib) or a C-type natriuretic peptide (BMN111, vosoritide) fully rescued the defective endochondral bone repair observed in Hch mice. …”
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Application Value of NT-proBNP Combined with NLR in Evaluation of Major Adverse Cardiac Events in Elderly Patients with Chronic Heart Failure by Zhiyong Li, Hui Rong, Wenxun Wu, Ting Huang, Jun Xu

“…To explore the application value of N-terminal pro-B type natriuretic peptide (NT-proBNP) combined with neutrophil-to-lymphocyte ratio (NLR) in evaluation of major adverse cardiac events (MACEs) in elderly patients with chronic heart failure (CHF). …”
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QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep by Bartosz Jarosław Przybył, Michał Szlis, Anna Misztal, Anna Wójcik-Gładysz

“…The study examined mRNA and peptide expression of TRH and TSH in the hypothalamus and pituitary, as well as plasma concentrations of TSH, free T4 (FT4) and free T3 (FT3). …”
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Predictors of radiological progression of rheumatoid arthritis while receiving conventional synthetic disease-modifying antirheumatic drugs by O. B. Iaremenko, G. M. Mykytenko

“…Rheumatoid factor (RF) was detected in 53.3 % of patients, and antibodies to cyclic citrullinated peptide (ACCP) – in 54.0 %. Logistic and linear regression were used to analyze independent risk factors for radiological progression of RA and results were expressed as odds ratio (OR). …”
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