Immobilization of Alkaline Collagenase from Bacillus subtilis onto Sulfonated Polystyrene Nanospheres for Hydrolysis of Tilapia Collagen by Ling Zhang, Xiaocui Yang, Kaijun Xiao, Yuyi Lu, Chunhai Li, Zijin Zhang

“…The structure of an alkaline protease from Bacillus subtilis used by a tilapia collagen peptide manufacturer was analyzed, and the technology of the enzyme immobilized by sulfonated polystyrene (SPS) nanoparticles was studied. …”
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Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury by Jeongsoo Han, Minjee Kwon, Myeounghoon Cha, Motomasa Tanioka, Seong-Karp Hong, Sun Joon Bai, Bae Hwan Lee

“…After ζ-pseudosubstrate inhibitory peptide (ZIP, a selective inhibitor of PKMζ) injection, mechanical allodynia test and immunoblotting of PKMζ, phospho-PKMζ (p-PKMζ), and GluR1 and GluR2 were observed. …”
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Ectopic ACTH Syndrome Emerging 5 Years after the Diagnosis of Neuroendocrine Tumor by Minghao Liu, Diane Hamele-Bena, John Ausiello, Gabrielle Page-Wilson

“…Serum cortisol was 61mcg/dL after an overnight 1mg dexamethasone suppression test (<1.8mcg/dL) and urinary free cortisol was 7544 mcg/24h (<45mcg/24h), establishing the diagnosis of Cushing’s syndrome. Plasma levels of peptides which have been associated with EAS, Agouti-related peptide (AgRP) and the ACTH precursors POMC (31-kDa) and pro-ACTH (22-kDa), were elevated. …”
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A retrospective analysis of migraine prophylaxis with anti-CGRP monoclonal antibodies at the hospital of Lithuanian University of Health Sciences Kaunas Clinics by V. Karpavičiūtė, K. Statkevičienė, G. Žemgulytė

“…Preventive treatment of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) is currently being widely investigated worldwide. …”
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A cell-based Papain-like Protease (PLpro) activity assay for rapid detection of active SARS-CoV-2 infections and antivirals. by Anahi G Jimenez-Campos, Lucas I Maestas, Nileena Velappan, Brian Beck, Chunyan Ye, Keith Wernsing, Yaniksa Mata-Solis, William J Bruno, Silas C Bussmann, Steven Bradfute, Justin T Baca, Frauke H Rininsland

“…The test system consists of a peptide that fluoresces when cleaved by SARS PLpro that is active in crude, unprocessed lysates from human tongue scrapes and saliva. …”
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Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study by Serdar Farhan, Ammon Handisurya, Jelena Todoric, Andrea Tura, Giovanni Pacini, Oswald Wagner, Katharina Klein, Rudolf Jarai, Kurt Huber, Alexandra Kautzky-Willer

“…GDM featured significantly lower insulin sensitivity and higher insulin and C-peptide secretion profiles compared to NGT during pregnancy (P<0.05). …”
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Modifications to rhesus macaque TCR constant regions improve TCR cell surface expression. by Lori V Coren, Matthew T Trivett, Jorden L Welker, James A Thomas, Robert J Gorelick, Emek Kose, Taina T Immonen, Kelli Czarra, Christine M Fennessey, Charles M Trubey, Jeffrey D Lifson, Adrienne E Swanstrom

“…All novel TCR constructs retained the ability to induce production of cytokines in response to cognate peptide antigen specific stimulation. This work can inform the design of TCRs selected for use in rhesus macaque models of TCR-based cellular immunotherapy.…”
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Protracted Hypocalcemia following 3.5 Parathyroidectomy in a Kidney Pancreas Recipient with a History of Robotic-Assisted Roux-en-Y Gastric Bypass by Hugo Bonatti, Naureen Iqbal, Catherine Kling, Willie Melvin, James Broome

“…A 41-old-year morbidly obese female with c-peptide negative diabetes mellitus and renal failure had RYGBP. …”
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Connexin 43 Communication Channels in Follicular Dendritic Cell Development and in Follicular Lymphomas by Hajnalka Rajnai, Ivett Teleki, Gergo Kiszner, Nora Meggyesházi, Peter Balla, Tamas Vancsik, Gyorgyi Muzes, Judit Csomor, Andras Matolcsy, Tibor Krenacs

“…In culture, the treatment of FDC-B cell clusters (resembling to “ex vivo” germinal centers) with Gap27 peptide, mimicking the 2nd extracellular loop of Cx43 protein, significantly impaired FDC-B cell cluster formation and cell survival. …”
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The Effect of Whey Protein Consumption on Postprandial Glucose, Insulin and Incretin Responses in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Acute-Term... by Zahra Salimi, Maryam Asadi, Anahita Mansoori

“…Results: The pooled analysis of the included trials indicated a significant reduction in the mean of glucose in the area under the curve [standard mean difference (SMD)=-1.295, 95% CI: -1.878 to -0.712, P<0.001] and also an increase in the mean of insulin, gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (SMD=0.562, 95% CI: 0.303 to 0.822, P<0.001, SMD=0.349, 95% CI: 0.074 to 0.624, P=0.013 and SMD=0.439, 95% CI: 0.154 to 0.724, P=0.003, respectively) in participants who consumed whey protein compared with the control group. …”
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Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women by Figen Topyildiz, Sinem Kiyici, Zulfiye Gul, Deniz Sigirli, Metin Guclu, Gurcan Kisakol, Sinan Cavun

“…These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide.…”
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DMSS: An Attention-Based Deep Learning Model for High-Quality Mass Spectrometry Prediction by Yihui Ren, Yu Wang, Wenkai Han, Yikang Huang, Xiaoyang Hou, Chunming Zhang, Dongbo Bu, Xin Gao, Shiwei Sun

“…Accurate prediction of peptide spectra is crucial for improving the efficiency and reliability of proteomic analysis, as well as for gaining insight into various biological processes. …”
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An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders by Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan

“…A defect in the clearance system either in terms of efficiency or capacity may occur due to massive cell death, which may result in the accumulation and leakage of PAD enzymes and the citrullinated peptide from the necrotized cell which could be recognized by the immune system, where the immunological tolerance will be avoided and the autoimmune disorders will be subsequently triggered. …”
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An electronic tongue system with automatic sample mixing function for long-term in-situ monitoring of chemical reactions by Chaoxian Jia, Yuezhong Mao, Jianxi Ying, Xiaofan Guo, Shiyi Tian, Weibo Zheng, Tao Zhang, Yufen Zhao, Kun Ding, Yan Liu

“…Proven effective in studying nucleotide selection and amino acid regulation during peptide formation, this device broadened the possibilities of automated monitoring designs and was deployed in the Wentian module of Tiangong space station, advancing the application prospects of the electronic tongue system in space chemistry.…”
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Predictive Value of Electromechanical Activation Time for In-Hospital Major Cardiac Adverse Events in Heart Failure Patients by Jing Zhang, Wen-Xian Liu, Shu-Zheng Lyu

“…EMATc, LVEF, and circulating levels of B type natriuretic peptide (BNP) and Troponin I (TnI) were measured. …”
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Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes by Xiu Zhang, Shengbang Wang, Wei Wang, Liumei Song, Shuo Feng, Jingping Wang, Tong Kang, Peiwen Yang, Ning Wang, Pengju Yang, Ruimin Bai, Yongping Shao, Yan Zheng

“…Extracellular cold-inducible RNA-binding protein (eCIRP) has been shown to play a role in various acute and chronic inflammatory diseases. C23, a short peptide derived from CIRP, competitively binds CIRP receptors and reduces damage in inflammatory diseases. …”
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The Role of Microbial Aspartic Protease Enzyme in Food and Beverage Industries by Jermen Mamo, Fassil Assefa

“…According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology, proteases are classified in enzymes of class 3, the hydrolases, and the subclass 3.4, the peptide hydrolases or peptidase. Proteases are generally grouped into two main classes based on their site of action, that is, exopeptidases and endopeptidases. …”
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Genome Structure of Bacillus cereus tsu1 and Genes Involved in Cellulose Degradation and Poly-3-Hydroxybutyrate Synthesis by Hui Li, Suping Zhou, Terrance Johnson, Koen Vercruysse, Ouyang Lizhi, Parthasarathy Ranganathan, Nsoki Phambu, Alexander J. Ropelewski, Theodore W. Thannhauser

“…The five PHB genes in tsu1 (phaA, phaB, phaR, phaC, and phaP) were cloned and expressed with TOPO cloning, and the recombinant proteins were validated using peptide mapping of in-gel trypsin digestion followed by mass spectrometry analysis. …”
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Predictive Value of Soluble Growth Stimulator Gene 2 Protein for Coronary Slow Flow/No-Reflow in ST-Elevation Myocardial Infarction Patients Receiving Percutaneous Coronary Interve... by Shu-min Chang, Yan-tan Yu, Bo Luan, Ai-jie Hou, Yong Wang

“…Statistically significant differences (P<0.05) were observed in age, diabetes mellitus, sST2 level, neutrophil-to-lymphocyte ratio (NLR), fasting blood sugar, preprocedural blood pressure, intraprocedural hypotension, N-terminal pro-B-type natriuretic peptide, MB isoenzyme of creatine kinase (CK-MB), and cardiac troponin I (cTNI). …”
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Lactobacillus from fermented bamboo shoots prevents inflammation in DSS-induced colitis mice via modulating gut microbiome and serum metabolites by Xiangru Liu, Xiaoling Lu, Hao Nie, Jing Yan, Zhiwen Ma, Hailin Li, Shixin Tang, Qi Yin, Jingfu Qiu

“…Meanwhile, they reduced the expression levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) inflammatory factors and increased zonula occludens-1 (ZO-1), Occludin, and cathelicidin-related antimicrobial peptide (CRAMP) in the colon. Consequently, these results demonstrated that Lactobacillus spp. isolates derived from FBS showed promising probiotic activity based on the gut microbiome homeostasis modulation, anti-inflammation and intestinal barrier protection in UC mice.…”
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