Deletion of bZIP Transcription Factor <i>PratfA</i> Reveals Specialized Metabolites Potentially Regulating Stress Response in <i>Penicillium raistrickii</i> by Anxin Zhang, Shu Zhang, Xinran Xu, Wen-Bing Yin

“…After the knockout of <i>PratfA</i>, a novel polyketide (PK) raistrilide A (<b>1</b>) and the known nonribosomal peptide (NRP) tunicoidine (<b>2</b>) subsequently disappeared. …”
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IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan by Paul L. Bollyky, Robert B. Vernon, Ben A. Falk, Anton Preisinger, Michel D. Gooden, Gerald T. Nepom, John A. Gebe

“…Pancreatic islets that expressed ovalbumin (OVA) antigen were implanted within this device for 14 days into immunodeficient mice that received OVA-specific DO.11.10 T cells and a subsequent immunization with OVA peptide. Splenocytes harvested from these mice produced IL-10 upon re-challenge with OVA or anti-CD3 antibodies. …”
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DIABETES MELLITUS IN PATIENTS WITH LIVER CIRRHOSIS: NEW TREATMENT OPTIONS by L. Yu. Morgunov

“…This article deals with the correction of carbohydrate metabolism in patients with cirrhosis and hepatocellular insufficiency of insulin analogs, biguanides, drugs with incretin effect — dipeptidyl peptidase‑4 inhibitors, agonists of glucagon-like peptide‑1, inhibitors of sodium-glucose cotransporter 2 diabetes. …”
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Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS by Jianan Zhang, Yuko Tsutsui, Hengyi Li, Tongqing Li, Yueyue Wang, Salma Laraki, Sofia Alarcon-Frias, Steven E. Stayrook, Daryl E. Klein

“…This includes beta-strands in dROS1’s third Fibronectin type III (FNIII) domain and a C-terminal peptide in BOSS’ ECR. Our mutagenesis studies, coupled with AlphaFold complex predictions, support a binding interaction mediated by a hydrophobic interaction and beta-strand augmentation between these regions. …”
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GLP1R boosts survival, migration and invasion of endometrial cancer cells and protects against ferroptotic cell death by Wu Li, Wen Lyu, Songjun Liu, Fan Ruan, Xinmei Zhang

“…Background Despite the strong evidence concerning carcinogenic roles of glucagon-like peptide 1 receptor (GLP1R), the role of this gene in endometrial cancer (EC) remains elusive. …”
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SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence by Luis D'Marco, Valery Morillo, José Luis Gorriz, María K. Suarez, Manuel Nava, Ángel Ortega, Heliana Parra, Nelson Villasmil, Joselyn Rojas-Quintero, Valmore Bermúdez

“…Over the last few years, the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) has increased substantially in medical practice due to their documented benefits in cardiorenal and metabolic health. …”
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Sex-Related Differences in the Effects of the Mediterranean Diet on Glucose and Insulin Homeostasis by Alexandra Bédard, Louise Corneau, Benoît Lamarche, Sylvie Dodin, Simone Lemieux

“…No sex difference was observed for glucose and C-peptide responses. Trends toward a decrease in NEFA AUC (P=0.06) and an increase in NEFA suppression rate (P=0.06) were noted, with no sex difference. …”
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Gut microbiome in non-alcoholic fatty liver disease by Anastasios Mpountouridis, Christina Tsigalou, Ioanna Bezirtzoglou, Eugenia Bezirtzoglou, Elisavet Stavropoulou

“…FXR activation decreases fat absorption and thus reduces hepatic lipid accumulation, while TGR5 activation promotes the release of glucagon-like peptide-1 (GLP-1) in blood. Furthermore, gut ethanol-producing bacteria has been implicated in NAFLD development. …”
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Regulation of Innate Lymphoid Cells in Acute Kidney Injury: Crosstalk between Cannabidiol and GILZ by Babak Baban, Hesam Khodadadi, Kumar Vaibhav, Cristina Marchetti, Carlo Riccardi, Mahmood S. Mozaffari

“…Mice subjected to unilateral renal IRI were treated with the following agents before restoration of renal blood flow: cannabidiol, DMSO, transactivator of transcription- (TAT-) GILZ, or the TAT peptide. Thereafter, kidney cells were prepared for flow cytometry analyses. …”
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Cardiac Effects of Thyrotropin Oversuppression with Levothyroxine in Young Women with Differentiated Thyroid Cancer by Kyung-Soon Hong, Jung-Woo Son, Ohk Hyun Ryu, Moon-Gi Choi, Ji Yeon Hong, Seong Jin Lee

“…Controls matched for age, sex, and body mass index (BMI) were compared in terms of the levels of serum free T4, free T3, TSH, plasma N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and cardiac functions and structures. …”
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Genotype B of deformed wing virus and related recombinant viruses become dominant in European honey bee colonies by Fabrice Sircoulomb, Eric Dubois, Frank Schurr, Pierrick Lucas, Marina Meixner, Alicia Bertolotti, Yannick Blanchard, Richard Thiéry

“…These were not randomly distributed, but mainly clustered in three genomic areas: the 5’UTR, leader peptide and helicase coding sequences. In our study, the DWV recombinant genomes shared at least the VP1-VP3 coding sequences with the DWV-B. …”
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Evaluation of B cell related markers and autoantibodies in rheumatoid arthritis patients treated with abatacept by Ting Wang, Natalia V. Giltiay, Christian Lood, Ning Wang, Bobby Kwanghoon Han

“…Baseline levels and longitudinal changes of markers were assessed between responders and nonresponders.ResultsBaseline levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies (p=0.01), IgM rheumatoid factor (RF) (p=0.02), CXC chemokine ligand 13 (CXCL13, p=0.02), sCD23 (p&lt;0.05), as well as frequencies of CD19+CD11c+IgD-CD27- B cells (p=0.04), were higher in responders than nonresponders. …”
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Artificial Intelligence Transforming Post-Translational Modification Research by Doo Nam Kim, Tianzhixi Yin, Tong Zhang, Alexandria K. Im, John R. Cort, Jordan C. Rozum, David Pollock, Wei-Jun Qian, Song Feng

“…Post-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones. Many PTMs profoundly impact cellular and molecular functions and structures, and their significance extends to evolutionary studies as well. …”
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Appetite Response among Those Susceptible or Resistant to Obesity by Rachel C. Brown, Rebecca T. McLay-Cooke, Sara L. Richardson, Sheila M. Williams, David R. Grattan, Alexandra W.-A. H. Chisholm

“…Fingerprick blood samples to measure ghrelin, total peptide YY (PYY), leptin, glucose, and insulin along with appetite ratings were collected at baseline and 15, 30, 60, 120, and 180 min following consumption of a standardized meal. …”
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Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? by Fulvia Ceccarelli, Matteo Saccucci, Gabriele Di Carlo, Ramona Lucchetti, Andrea Pilloni, Nicola Pranno, Valeria Luzzi, Guido Valesini, Antonella Polimeni

“…Moreover, the possible role of proinflammatory cytokines, such as TNF and IL6 and autoantibodies, specifically anticyclic citrullinated peptide antibodies, has been examined, suggesting the need to perform further studies to better define this issue.…”
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Preventive effect of kiwi berry (Actinidia arguta) on loperamide-induced constipation by Jiyue Zhang, Bin Li, Ningxuan Gao, Haikun Li, Xingyue Cui, Hanqian Jiang, Siyi Tang, Chenyu Jin, Jinlong Tian

“…In the interstitial cells of Cajal (ICC) cells and colon tissues, alterations in the protein expression of vasoactive intestinal peptide (VIP), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and aquaporin-3 (AQP3) were found. …”
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Expression of the Gene Encoding the Brucella abortus BAB1-0278 Antigen in Probiotic Lactococcus lactis Bacteria by donya kazemi, abbas doosti, mostafa Shakhsi niaee

“…Materials and Methods: The gene construction design contains a signal peptide sequence in the nisin-based expression vector (pN3z8148-Usp45-BAB1-0278) and is synthesized by GENEray. …”
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Salivaricin G32, a Homolog of the Prototype Streptococcus pyogenes Nisin-Like Lantibiotic SA-FF22, Produced by the Commensal Species Streptococcus salivarius by Philip A. Wescombe, Kristin H. Dyet, Karen P. Dierksen, Daniel A. Power, Ralph W. Jack, Jeremy P. Burton, Megan A. Inglis, Anna L. Wescombe, John R. Tagg

“…Salivaricin G32, a 2667 Da novel member of the SA-FF22 cluster of lantibiotics, has been purified and characterized from Streptococcus salivarius strain G32. The inhibitory peptide differs from the Streptococcus pyogenes—produced SA-FF22 in the absence of lysine in position 2. …”
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An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity by Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung

“…The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model. …”
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Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers by Howida A. Fetouh, Engy E. A. Aleem, Najiyah H. Mohammed, Jihad M. Abd-Almajeed Aldesouky, Amel M. Ismail

“…Release kinetic depend on physicochemical characteristics (porosity, swelling ratio as well as peptide and amino acid sequence). Both IDDs showed negative zeta potential indicating stability against aggregation. …”
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