Treatment of Heart Failure with Sodium-glucose Cotransporter Type 2 Inhibitors by Riber Fabián Donoso Noroña, Nairovys Gómez Martínez, Adisnay Rodríguez Plasencia

“…The results showed that the treatment significantly reduced the risk of hospitalization for heart failure and cardiovascular mortality compared with placebo or standard care, and that sodium-glucose cotransporter type 2 inhibitors improved cardiac function and reduced levels of B-type natriuretic peptide, a biomarker of cardiac stress. The results of this study support the inclusion of sodium-glucose cotransporter type 2 inhibitors in the treatment of heart failure in patients with or without type 2 diabetes. …”
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Upper Gastrointestinal Bleeding from Gastric Amyloidosis in a Patient with Smoldering Multiple Myeloma by Mihajlo Gjeorgjievski, Treta Purohit, Mitual B. Amin, Paul J. Kurtin, Mitchell S. Cappell

“…Liquid chromatography tandem mass spectrometry performed on peptides extracted from Congo red-positive microdissected areas of paraffin-embedded stomach specimens revealed a peptide profile consistent with AL- (lambda-) type amyloidosis. …”
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Multifocal Insulinoma in Pancreas and Effect of Intraoperative Ultrasonography by Ersin Borazan, Alper Aytekin, Latif Yilmaz, Muhsin Elci, Mehmet Salih Karaca, Selim Kervancioglu, Ahmet Abdulhalik Balik

“…The present case was examined with the findings of hypoglycemia and hypercalcemia, and as there was high insulin and C-peptide levels the initial diagnosis was insulinoma. …”
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Spectroscopically Well-Characterized RGD Optical Probe as a Prerequisite for Lifetime-Gated Tumor Imaging by Julia Eva Mathejczyk, Jutta Pauli, Christian Dullin, Joanna Napp, Lutz-F. Tietze, Horst Kessler, Ute Resch-Genger, Frauke Alves

“…Labeling of RGD peptides with near-infrared fluorophores yields optical probes for noninvasive imaging of tumors overexpressing α v β 3 integrins. …”
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Obesity Hypertension: The Regulatory Role of Leptin by Shilpa Kshatriya, Kan Liu, Ali Salah, Tamas Szombathy, Ronald H. Freeman, Garry P. Reams, Robert M. Spear, Daniel Villarreal

“…Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. …”
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Potential renoprotective effects and possible underlying mechanisms of angiotensin receptor-neprilysin inhibitors in cardiorenal syndrome by Md. Moshiur Rahman, Md. Moshiur Rahman, Asadur Rahman, Akira Nishiyama

“…Angiotensin receptor-neprilysin inhibitors (ARNIs) represent a novel class of medications characterized by their dual action on major cardiorenal regulators, specifically the renin–angiotensin system (RAS) and the natriuretic peptide (NP) system. Sacubitril/valsartan, a pioneering ARNI, has demonstrated strong antihypertensive effect as well as superior efficacy in preserving renal function compared to RAS inhibitors in heart failure patients with reduced ejection fraction. …”
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Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis by Joachim Sieper, Juergen Braun

“…The arthritogenic peptide hypothesis trying to explain the pathogenesis of AS is based on that very immune function assuming that also self peptides can be presented. …”
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Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease by Benoît Leclerc, Abedelnasser Abulrob

“…The most promising diagnostic strategies in today’s world would consist in performing high diagnostic accuracy of combined modality imaging technologies using beta-amyloid 42 peptide-cerebrospinal fluid (CSF) positron emission tomography (PET), Pittsburgh compound B-PET, fluorodeoxyglucose-PET, total and phosphorylated tau-CSF, and volumetric magnetic resonance imaging hippocampus biomarkers for criteria evaluation and validation. …”
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Echocardiographic Assessment of Left Ventricular Function in Type 1 Gaucher's Disease by Mirta Koželj, Samo Zver, Vesna Zadnik

“…The obtained data was correlated with the levels of NT-proBNP (brain natriuretic peptide). None of the GD patients had clinical signs of heart disease. …”
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Charge-Based Inhibitors of Amylin Fibrillization and Toxicity by Sharadrao M. Patil, Andrei T. Alexandrescu

“…Mem-T substitutes negatively charged aspartates for the peptide segment with the largest avidity for membranes. …”
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Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15 by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Viviani

“…Glucose-dependent insulinotropic peptide (GIP) is an incretin hormone produced in the gastrointestinal tract that stimulates glucose dependent insulin secretion. …”
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Distinguishing rheumatoid arthritis from psoriatic arthritis by Joseph F Merola, Luis R Espinoza, Roy Fleischmann

“…Patients with PsA typically have seronegative test findings for rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies, while approximately 80% of patients with RA have positive findings for RF and CCP antibodies. …”
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Musculoskeletal Ultrasonography in Detecting Disease Activity in Patients of Juvenile Idiopathic Arthritis: A Cross-Sectional Study by Sharad Dev, Ashish Verma, Anup Singh

“…A significant correlation between erosions and rheumatoid factor and anti-cyclic citrullinated peptide values was found. Conclusion: Our study found that MSUS has a definite role in assessing the disease activity in JIA patients and this modality may be considered as an adjunct in this context, as well as considered for future inclusion in classification criteria for JIA.…”
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Ketogenic Diet-Induced Diabetic Ketoacidosis in a Young Adult with Unrecognized Type 1 Diabetes by Suranut Charoensri, Jin Sothornwit, Akeatit Trirattanapikul, Chatlert Pongchaiyakul

“…Diabetic ketoacidosis was diagnosed by elevated capillary blood glucose, significant metabolic acidosis, and a high serum beta-hydroxybutyrate level. Low C-peptide level and positive islet autoantibodies confirmed the new diagnosis of type 1 diabetes in this patient. …”
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Coexisting rheumatoid arthritis and sickle cell disease: case series and literature review by Abdallah Alqethami, Sabri Alsaeedi, Samera Felemban, Abdulelah Qadi

“…Most of the patients were positive for rheumatoid factor (6/7) or anticyclic citrullinated peptide (6/7). Four patients were treated with hydroxyurea. …”
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Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus by Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian

“…Mature hIAPP, a 37-aa peptide, is natively unfolded in its monomeric state but forms islet amyloid in T2DM. …”
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Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment by Karsten Buschard, Laurits J. Holm, Ulla Feldt-Rasmussen

“…She has now been insulin independent for one year and 9 months. Unstimulated C-peptide has increased by 51% (317 to 479 pmol/l), and IA-2 autoantibody level has decreased by 65% (49 to 17 × 103 arbitrary units). …”
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Methodological considerations and implications for appetite and feeding behaviour research in PKU; Current knowledge, practical application and future perspectives by Ben Green

“…Regulated through homeostatic and non-homeostatic influences, appetite-related peptides and external cues existing in the physical environment work synergistically to maintain energy homeostasis. …”
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AT2 Receptor-Interacting Proteins ATIPs in the Brain by Sylvie Rodrigues-Ferreira, Erwann le Rouzic, Traci Pawlowski, Anand Srivastava, Florence Margottin-Goguet, Clara Nahmias

“…Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. …”
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Thermosensitive Chitosan-β-Glycerophosphate Hydrogels as Targeted Drug Delivery Systems: An Overview on Preparation and Their Applications by Pouria Rahmanian-Devin, Vafa Baradaran Rahimi, Vahid Reza Askari

“…Hydrogels are used in many drug delivery systems and diseases, including nasal drug delivery, vaginal drug delivery, wound healing, peritoneal adhesion, ophthalmic drug delivery, tissue engineering, and peptide and protein delivery. Overall, the chitosan-β-glycerophosphate hydrogel is a suitable drug carrier for a wide range of drugs. …”
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