Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…The natural antimicrobial peptides are ancient host defense effector molecules, present in organisms across the evolutionary spectrum. …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

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Immunological Aspects of Fulminant Type 1 Diabetes in Chinese by Zhen Wang, Ying Zheng, Yiting Tu, Zhijie Dai, Jian Lin, Zhiguang Zhou

“…And peripheral T cell responses to GAD65, insulin B9–23 peptide, or C peptide were determined in 10 FT1D patients and 10 healthy controls. …”
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Heterologous Expression and Transglycosylation of Acarviosyltransferase by XUE Zhenglian, WANG Yuqing, LI Chuang, LI Dandan, ZHU Sibao, LI Xiangfei

“…Bioinformatics analysis showed that the conserved domains of ATase, the expression product of acbD, were highly similar to those of cyclodextrin glycosyltransferase, which belongs to the glycoside hydrolase 13 (GH13) family, and ATase possessed a signal peptide and a transmembrane domain. After removal of the coding sequences in the signal peptide, the soluble expression level of acbD increased by 23.4 times as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). …”
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Comparative analysis of the Streptococcus pneumoniae competence development in vitro versus in vivo during pneumonia-derived sepsis by Sook Yin Chong, Shi Qian Lew, Tauqeer Alam, Christopher A. Gaulke, Gee W. Lau

“…Some pneumococcal strains can enter a transient competent state for genetic transformation in an optimized competence-inducing medium when the threshold level of the peptide pheromone competence stimulating peptide is attained; upregulating the expression of three distinct phases of “early”, “late” and “delayed” competence genes. …”
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Micro-MRI at 11.7 T of a Murine Brain Tumor Model Using Delayed Contrast Enhancement by Rex A. Moats, Sendhil Velan-Mullan, Russell Jacobs, Ignacio Gonzalez-Gomez, David J. Dubowitz, Takashi Taga, Vazgen Khankaldyyan, Linda Schultz, Scott Fraser, Marvin D. Nelson, Walter E. Laug

“…These strategies were applied to monitor the growth of brain tumors xenotransplanted into nude mice and either treated with the antiangiogenic peptide EMD 121974 or an inactive control peptide. …”
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Daropeptide natural products by Suze Ma, Sijia Guo, Wei Ding, Qi Zhang

“…Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. …”
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Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. by Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas

“…By inactivation of the nonribosomal peptide synthetase SidC, we demonstrate that the intracellular siderophores are required for germ tube formation, asexual sporulation, resistance to oxidative stress, catalase A activity, and virulence. …”
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Organizing Pneumonia Preceding Rheumatoid Arthritis by Yoshiaki Kinoshita, Atsuhiko Sakamoto, Kouko Hidaka

“…We suggest that patients with organizing pneumonia and positive for either rheumatoid factor or anticyclic citrullinated peptide antibody should be cautiously followed up regarding the development of rheumatoid arthritis, particularly during the first year after the diagnosis of organizing pneumonia.…”
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Factors Affecting the Readmission of Patients with Pancreatic Cancer after Surgery by Xiaojing Gu, Wei Zhou, Juan Han

“…At 7, 14, and 21 days postsurgery, the levels of gastrointestinal hormones motilin, gastrin, calcitonin gene-related peptide, and growth hormone-releasing peptide of the observation group were lower than the control group, while the levels of adrenocorticotropin, renin, angiotensin, and plasma aldosterone of the observation group were significantly higher than the control group. …”
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Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

“…These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain. Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin. …”
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Side-Stream Based Marine Solubles From Atlantic Cod (Gadus morhua) Modulate Appetite and Dietary Nutrient Utilization in Atlantic Salmon (Salmo salar L.) and can Replace Fish Meal by Hanne Jorun Sixten, Ivar Rønnestad, André S. Bogevik, Tone Aspevik, Åge Oterhals, Ana S. Gomes, Floriana Lai, Ingvill Tolås, Virginie Gelebard, Marie Hillestad, Katerina Kousoulaki

“…Expression of stomach ghrelin-1 (ghrl1) was higher than ghrelin-2 (ghrl2) and membrane-bound O-acyltransferase domain-containing 4 (mboat4), and midgut peptide YYa-2 (pyya2) and glucagon-a (gcga) were higher than peptide YYb-1 (pyyb1). …”
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Synthesis and structural characterization of s-triazine derivatives and their photophysical properties by Hessa H. Al-Rasheed, Sizwe J. Zamisa, Ihab Shawish, Assem Barakat, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio, Anamika Sharma

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A reference genome for the eastern bettong (Bettongia gaimardi) [version 2; peer review: 2 approved, 1 approved with reservations] by Richard J Edwards, Luke W Silver, Sam Banks, Carolyn J Hogg, Adrian D. Manning, Linda Neaves

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Characterization and Synergistic Antimicrobial Evaluation of Lipopeptides from Bacillus amyloliquefaciens Isolated from Oil-Contaminated Soil by Pratiwi Sudarmono, Ahmad Wibisana, Lira W. Listriyani, Saleha Sungkar

“…By tandem mass spectrometry, five variants of surfactin with the same amino acid sequence in peptide moiety could be revealed. The peptide moiety contains seven amino acids identified as Glu-Leu/Ile-Leu-Val-Asp-Leu-Leu/Ile while the fatty acid moiety comprises a different length of chain from C12 to C16. …”
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Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives by Amit Pithadia, Jeffrey R. Brender, Carol A. Fierke, Ayyalusamy Ramamoorthy

“…Furthermore, we have outlined possible mechanistic discoveries of the interaction of these small molecules with the peptide and how they may mitigate toxicity associated with peptide aggregation. …”
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N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19 by Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson

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Computational screening, synthesis and neuroprotective evaluation of small molecule for the treatment of alzheimer's disease by Nerlis Pajaro-Castro, Elkin Torres-Sierra, Edwar Cortes-Gonzalez, Margaret Paternina, Erwin Camacho, Pedro Blanco

“…Cytotoxicity and neuroprotective effects were assessed using the MTT assay in the presence of the Aβ25-35 peptide. RESULTS: Four candidate molecules showed strong binding affinity, ranging from -6.8 to -9.1 kcal/mol. …”
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A Full GMP Process to Select and Amplify Epitope-Specific T Lymphocytes for Adoptive Immunotherapy of Metastatic Melanoma by N. Labarriere, A. Fortun, A. Bellec, A. Khammari, B. Dreno, S. Saïagh, F. Lang

“…We have previously described a sorting method of epitope-specific T lymphocytes that uses magnetic beads coated with HLA/peptide complexes and we suggested that this method could be applied to a clinical setting. …”
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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity by Evelyn F Okal, Philip A. Romero, Pete Heinzelman

“…Abstract Background Angiotensin-Converting Enzyme 2 (ACE2) is a crucial peptidase in human peptide hormone signaling, catalyzing the conversion of Angiotensin-II to Angiotensin-(1–7), which activates the Mas receptor and elicits vasodilation, increased blood flow, reduced inflammation, and decreased pathological tissue remodeling. …”
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