Protein Repair and Degradation during Aging by Bertrand Friguet

“…Arguments for the implication of peptide methionine sulfoxide reductase in the age-related accumulation of oxidized protein are also discussed.…”
Get full text

Integrated analysis of ATAC-seq and RNA-seq reveals ADSCP2 regulates oxidative phosphorylation pathway in hypertrophic scar fibroblasts by Qian Li, Zhe Quan, Ling Chen, Yiliang Yin, Xin Chen, Jingyun Li

“…The primary effector cells involved in the formation of hypertrophic scars are fibroblasts. A potential peptide, ADSCP2 (adipose-derived stem cell peptide 2, the peptide fragment of ALCAM protein), derived from adipose-derived stem cell-conditioned medium, has been identified as having the potential to mitigate hypertrophic scar formation by targeting pyruvate carboxylase. …”
Get full text

Characterization of Streptomyces Isolates Associated with Estuarine Fish Chanos chanos and Profiling of Their Antibacterial Metabolites-Crude-Extract by Muhammad A. Kurnianto, Harsi D. Kusumaningrum, Hanifah N. Lioe

“…The results of this study indicated that some Streptomyces isolated from new environmental niches, i.e., gut of estuarine fish Chanos chanos, produce promising peptide-containing bioactive compounds.…”
Get full text

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression by Michela Cioni, Christian Mittelholzer, Marion Wernli, Hans H. Hirsch

“…Effects of agnoprotein on viral peptide-dependent T-cell killing were investigated using 51Cr release. …”
Get full text

Cloning, expression analysis, and the photoperiodic response of CHH gene in Panulirus homarus by Zhimin Ju, Jiajun Luo, Charles Brighton Ndandala, Chongqing Wen, Zhao Yanfei, Huafang Liang

“…PhCHH-A and PhCHH-B possess most of the characteristics of eyestalk type-I CHH/MIH/GIH family neuropeptides. Both have a “signal peptide, CPRP, and mature peptide” structure. Their mature peptide comprised 74 amino acids and 6 cysteine residues in a conserved position. …”
Get full text

Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…The identification and prioritization of patient-specific tumor neoantigens are based on advanced computational algorithms taking advantage of the profiling with next-generation sequencing considering factors involved in human leukocyte antigen (HLA)-peptide-T-cell receptor (TCR) complex formation, including peptide presentation, HLA-peptide affinity, and TCR recognition. …”
Get full text

Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success by Lanfranco Pellesi, Lars Edvinsson

“…Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activating peptide (PACAP) in migraine prevention, which highlight the importance of targeting peptides, this proposal reexamines substance P as a mediator in migraine pathophysiology. …”
Get full text

Structure and Physiological Actions of Ghrelin by Christine Delporte

“…Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. …”
Get full text

Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…A broad-spectrum CD8+ T-cell epitope library containing 141 validated epitope peptides was used to universally detect HIV-1-specific CD8+ T cells via peptide-PBMC ex vivo coculture and intracellular IFN-γ staining. …”
Get full text

Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study by Pranjali Shah

“…Laboratory results showed uncontrolled hyperglycemia, absence of C-peptide, and positive for anti-GAD. Treatment involved CGMS fixation and insulin degludec/aspart, leading to excellent sugar control. …”
Get full text

Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…PTHrP is a polyhormone undergoing proteolytic processing into smaller bioactive forms, comprising an N-terminal peptide, which is the mediator of the “classical” PTH-like effect, as well as midregion and C-terminal peptides. …”
Get full text

Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N by Julius Bogomolovas, Ju Chen

“…Our method identified a new PKN substrate peptide that we optimized for use in a fluorescent biosensor design. …”
Get full text

Profiling protease cleavage patterns in plasma for pancreatic cancer detection by Morgan R. Stewart, Arnaud Quentel, Elise Manalo, Jose Montoya Mira, Srivathsan Ranganathan, Bruce P. Branchaud, Jared M. Fischer, Eugene Tu, Fehmi Civitci, Yu-Jui Chiu, Adem Yildirim

“…Their enzymatic activity against peptide substrates allows for their straightforward detection using low-cost tests. …”
Get full text

TT Mutant Homozygote of Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children by Jung Ran Choi, In-Su Kwon, Dae Young Kwon, Myung-Sunny Kim, Myoungsook Lee

“…In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p = 0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust r2 = 1.000, p < 0.001, respectively). …”
Get full text

Are Trends in Economic Modeling of Pediatric Diabetes Mellitus up to Date with the Clinical Practice Guidelines and the Latest Scientific Findings? by Roque Cardona-Hernandez, Alberto de la Cuadra-Grande, Julen Monje, María Echave, Itziar Oyagüez, María Álvarez, Isabel Leiva-Gea

“…Eight models included diabetic ketoacidosis (42.1%), 16 included hypoglycemia (84.2%), 2 included C-peptide (1 of those as prognostic factor) (10.5%) and 1 included legacy effect (5.3%). …”
Get full text

Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body by Luis Leon-Mercado, Ivan Menendez-Montes, Jonathan Tao, Bandy Chen, David P. Olson, C. Mackaaij, C.G.J. Cleypool, Laurent Gautron

“…Agouti-related peptide (AgRP) is a well-established potent orexigenic peptide primarily expressed in hypothalamic neurons. …”
Get full text

Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by A. N. Chikaev, A. P. Rudometov, Yu. A. Merkulyeva, L. I. Karpenko

“…Each phage particle in a library displays peptides or proteins fused to its coat protein and simultaneously carries the DNA sequence encoding the displayed peptide/protein in its genome. …”
Get full text

Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes by Yanhua Yin, Xiaoying Ding, Liang Peng, Yanqiang Hou, Yunxia Ling, Mingyu Gu, Yufan Wang, Yongde Peng, Haiyan Sun

“…Serum ANGPTL8 was positively correlated with FPG, fasting C-peptide, and postprandial C-peptide and negatively correlated with BETA/IR when adjusted for age and BMI. …”
Get full text

Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC0–0.5, AUC0–1, AUC0–3 (P<0.05). …”
Get full text

Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yu-Chen Chang, Chien-Ju Lin, Yu-Hsuan Hsiao, Yu-Han Chang, Shu-Jung Liu, Hsin-Yin Hsu

“…The results of HbA1c and fasting C-peptide levels were extracted for further quantitative assessment. …”
Get full text