Laxative Effect of Lacticaseibacillus rhamnosus Glory LG12: from the Perspective of the Stem Cell Factor/C-kit Signaling Pathway by XIANG Fangqin, LI Yuxing, LI Bailiang

Subjects: “…lacticaseibacillus rhamnosus glory lg12; constipation; laxative effect; inflammatory cytokines; gastrointestinal regulatory peptides; stem cell factor/c-kit signaling pathway…”
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Accuracy of Established Prognostic Staging Systems for Cardiac Transthyretin Amyloidosis in the Tafamidis Era by Maximilian Leo Müller, MD, Sebastian Spethmann, MD, Daniel Messroghli, MD, Anna Brand, MD, Isabel Mattig, MD, Katrin Hahn, MD, Ulf Landmesser, MD, Bettina Heidecker, MD

Subjects: “…N-terminal pro B-type natriuretic peptide (NT-proBNP)…”
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Author Correction: Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee

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Clinical and Biochemical Features Used to Classify Type-1 and Type-2 Diabetes: A Scoping Review by Ulagamadesan Venkatesan, Anandakumar Amutha, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Bagavandas Mappillairajan, Viswanathan Mohan

“…Clinical parameters including family history of diabetes, age at diagnosis, sex, history of insulin use, percent desirable weight or body mass index, waist, and blood pressure emerge as pivotal diagnostic tools. C-peptide measures, encompassing urinary C-peptide to creatinine ratio (UCPCR), and serum fasting and stimulated C-peptide levels further augment classification. …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

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Antioxidant and Renin-Angiotensin System Inhibitory Properties of Cashew Nut and Fluted-Pumpkin Protein Hydrolysates by Sunday A. Malomo, Ifeanyi D. Nwachukwu, Abraham T. Girgih, Atinuke O. Idowu, Rotimi E. Aluko, Tayo N. Fagbemi

“…Amino acid composition revealed that CNPH had 28% hydrophobic residues when compared to higher contents (32-35%) in the 3-10 kDa peptide fractions. In contrast, aromatic residues increased from 8% in the FPPH to 9-13% in the peptide fractions. …”
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Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study by Kun Lin, Xiaoping Yang, Yixi Wu, Shuru Chen, Qiong Zeng

“…Age at diagnosis was the strongest predictor for residual C-peptide. There was a more rapid decline of stimulated C-peptide in duration ≤5 years and younger patients. …”
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Intricacies for Posttranslational Tumor-Targeted Cytokine Gene Therapy by Jeffry Cutrera, Denada Dibra, Arun Satelli, Xuexing Xia, Shulin Li

“…Here, the impact on efficacy of the location of targeting peptide, choice of targeting peptide, tumor histotype, and cytokine utilization are studied in multiple syngeneic murine tumor models. …”
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Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction by Anna Maria Papini, Francesca Nuti, Feliciana Real-Fernandez, Giada Rossi, Caterina Tiberi, Giuseppina Sabatino, Shashank Pandey, Silvia Leoncini, Cinzia Signorini, Alessandra Pecorelli, Roberto Guerranti, Solange Lavielle, Lucia Ciccoli, Paolo Rovero, Claudio De Felice, Joussef Hayek

“…To determine immunoglobulins we used both a conventional agglutination assay and a novel ELISA based on antibody recognition by a surrogate antigen probe, CSF114(Glc), a synthetic N-glucosylated peptide. Both assays provided evidence for an increase in IgM titer, but not in IgG, in RTT patients relative to both healthy controls and non-RTT PDD patients. …”
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Energetics of substrate transport in proton-dependent oligopeptide transporters by Balaji Selvam, Nicole Chiang, Diwakar Shukla

“…Abstract The PepTSo transporter mediates the transport of peptides across biological membranes. Despite advancements in structural biology, including cryogenic electron microscopy structures resolving PepTSo in different states, the molecular basis of peptide recognition and transport by PepTSo is not fully elucidated. …”
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Towards a Quantitative Description of Proteolysis: Contribution of Demasking and Hydrolysis Steps to Proteolysis Kinetics of Milk Proteins by Mikhail M. Vorob’ev

“…The two-step proteolysis model is regarded, which includes demasking of peptide bonds as a result of opening of the protein structure at the first stage, then hydrolysis of the demasked peptide bonds. …”
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The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. by Alexander M Cole, Dorothy L Patton, Lisa C Rohan, Amy L Cole, Yvonne Cosgrove-Sweeney, Nicole A Rogers, Deena Ratner, Alexandra B Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I Lehrer, Alan J Waring, Phalguni Gupta

“…One day following the last film application, cervical biopsies from RC-101-exposed and placebo-controlled macaques were collected and were subjected to challenge with RT-SHIV in an ex vivo organ culture model. RC-101 peptide was detected primarily in the cytobrush and biopsied cervical and vaginal tissues, with little to no peptide detected in lavage samples, suggesting that the peptide was associated with the cervicovaginal epithelia. …”
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Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach by Riska Ayu Sutriyansyah, Muhamad Hilmi Ihsanul Iman, Cahya Ajeng Valenta Tresna Sulung, Nelly Indira Kusuma Wardani, Arif Nur Muhammad Ansori

“…This research showed that the peptide sequence of "EWFHDIPLPWHAGADTGTPHWNNKEA" (peptide 6E) in the envelope protein E of ZIKV is a potential vaccine candidate. …”
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Influence of Running and Walking on Hormonal Regulators of Appetite in Women by D. Enette Larson-Meyer, Sonnie Palm, Aasthaa Bansal, Kathleen J. Austin, Ann Marie Hart, Brenda M. Alexander

“…Plasma concentrations of the orexogenic peptide ghrelin, anorexogenic peptides peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and appetite ratings were measured at 30 min interval for 120 min, followed by a free-choice meal. …”
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Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee

“…Decreased expression of the neuronal marker MAP2 and synaptic markers PSD95 and synaptophysin in AD mice was significantly reversed. Levels of Aβ peptides and plaques were markedly reduced. Furthermore, we showed that soluble ectodomains of both type I and type III NRG1 significantly increased expression of Aβ-degrading enzyme neprilysin (NEP) in primary neuronal cultures. …”
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A dual expression plasmid with Microcin B17 compatible with both prokaryotic and mammalian systems by Agnieszka M. Murakami, Katsuhiro Nagatomo, Hiroshi Koda, Yasutaka Niwa, Manabu Murakami

“…However, the need for shorter peptide toxins has emerged. In this study, we evaluated the utility of microcin B17 (MccB17), a peptide consisting of 43 amino acids, in promoting DNA recombination within pgMAX-II, a dual expression plasmid for both prokaryotic and mammalian systems. …”
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Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two‐Centre Open, Single‐Arm Trial by Chuanfeng Liu, Yu Xin, Yajing Huang, Lili Xu, Ruizhi Zhou, Yangang Wang, Wei Wang

“…Results Q2 group showed an average reduction in liver fat content of 8.6%, a decrease in glycated haemoglobin of 18.17%, a weight loss of 7.29% and an increase in fasting c‐peptide release by 1.03%, 1‐h and 2‐h postprandial c‐peptide release by 28.86% and 18.28% respectively. …”
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Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity by O. A. Smirnov

“…Hepcidin is coded by HAMP gene (Hepcidin Antimicrobial Peptide) in chromosome 19. Expression peptide mRNA in hepatocytes is induced by proinflammatory cytokines (IL-1α, IL-6 and TNF-α) similar to acute phase proteins of inflammation, and also by liver iron overload. …”
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Identification of fine antigenic epitopes of Tamdy virus glycoprotein Gn fragment and establishment of ELISA detection method by Yujiao Fu, Liping Liu, Beibei Zhang, Xiaoshan Chao, Junxia Jin, Ying Wang, Juntao Ding

“…According to the predicted results, glycoprotein Gn was divided into 46 truncated 16-peptides by modified synthetic peptide method, and the antigenicity of 46 truncated 16-peptides was verified by western blotting analysis. …”
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Antibodies directed against bacterial antigens in sera of Polish patients with primary biliary cholangitis by Alicja Bauer, Andrzej Habior

“…We observed inhibition of specific antigen-antibody binding by the bacterial peptide: EClpP (E. coli caseinolytic protease) and adenine glycosylase from E. coli caseinolytic protease P, ClpP Y.e from peptide of Y. enterolitica, Mp PDC from M. pneumonia peptide and adenine glycosylase of E. coli. …”
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