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  1. 741

    Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

    Published 2025-02-01
    “…Pegmolesatide (by Hansoh Pharma) is currently the only marketed long-acting EPO mimetic peptide (EMP) for the treatment of anemia in both dialysis and non-dialysis CKD patients. …”
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    Article
  2. 742

    Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation by Yin Zhang, Tinglian Zhou, Kai Wang, Chenqi Luo, Dan Chen, Zeen Lv, Haijie Han, Ke Yao

    Published 2025-01-01
    “…This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, the sialic acid‐targeting peptide prolongs ocular surface retention, further enhancing therapeutic efficacy. …”
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    Article
  3. 743

    In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment by Wangxiao He, Fan Ding, Liqiang Zhang, Wenjia Liu

    Published 2025-01-01
    “…To mimic this property, a viscoelastic peptide bionic hydrogel named BCgel was developed, featuring a nanofiber network, Itgb1 binding affinity, BC-like viscoelasticity, and biosafety. …”
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  4. 744

    Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration by Sadhana M. Gupta, Clara C. Aranha, Madhu C. Mohanty, K. V. R. Reddy

    Published 2008-01-01
    “…In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP), for its efficacy as an intravaginal microbicide. …”
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    Article
  5. 745

    Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic by Edwin C. Jones, J. Craig Rylands, Cortney L. Jardet

    Published 2018-01-01
    “…By the age of 55, the patient no longer required any insulin and is currently being managed with metformin alone. C-peptide values indicate a functional improvement of the β-islet cells during the time of insulin/GABA/probiotic treatment.…”
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  6. 746

    Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells by Silvia Orisio, Marina Morigi, Carla Zoja, Norberto Perico, Giuseppe Remuzzi

    Published 1992-01-01
    “…TNF-α induced endothelin-1 gene expression was associated with a parallel increase in the release of the corresponding peptide in the culture medium. These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.…”
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    Article
  7. 747

    Adropin as an indicator of T2DM and its complications by Hu Zhang, Ning Chen

    Published 2022-11-01
    “…Therefore, the prevention and treatment of T2DM and its complications has become an urgent problem to be solved. As a secreted peptide, adropin is identified as a useful regulator associated with insulin sensitivity and energy homeostasis. …”
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    Article
  8. 748

    Angiotensin-Converting Enzyme 2: The First Decade by Nicola E. Clarke, Anthony J. Turner

    Published 2012-01-01
    “…The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin-converting enzyme (ACE) mediating an increase in blood pressure. …”
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    Article
  9. 749

    Effectiveness and Safety of Newer Antidiabetic Medications for Ramadan Fasting Diabetic Patients by Ehab Mudher Mikhael

    Published 2016-01-01
    “…New glucose-lowering classes like dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 receptor agonist (GLP-1 RA), and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are efficacious in controlling blood glucose level with less tendency to induce hypoglycemia and thus may constitute a good choice for diabetic patients during Ramadan. …”
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    Article
  10. 750

    A molecular toolkit for heterologous protein secretion across Bacteroides species by Yu-Hsuan Yeh, Vince W. Kelly, Rahman Rahman Pour, Shannon J. Sirk

    Published 2024-11-01
    “…To understand the mechanistic drivers of Bacteroides secretion, we characterize signal peptide sequence features, post-secretion extracellular fate, and the size limit of protein cargo. …”
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    Article
  11. 751

    Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat by Jasińska-Stroschein Magdalena, Owczarek Jacek, Wesołowska Anna, Orszulak-Michalak Daria

    Published 2014-09-01
    “…Right ventricular pressure, right ventricle mass and three biomarkers were evaluated after 21 days: brain natriuretic peptide, high-density lipoprotein cholesterol and vascular endothelial growth factor. …”
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    Article
  12. 752

    Epitope mapping of recombinant Salmonella enterica serotype Heidelberg flagellar hook-associated protein by in silico and in vivo approaches by Hung-Yueh Yeh

    Published 2025-02-01
    “…The results show that both approaches identified three common shared consensus peptide epitope sequences at the positions of 77–95, 243–255 and 358–373 in the Salmonella serotype Heidelberg FlgK protein. …”
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    Article
  13. 753

    Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin by Satoru Ken Nishimoto, Miyako Nishimoto

    Published 2014-01-01
    “…The binding site for fibronectin is in a MGP C-terminal peptide comprising amino acids 61–77. Second, MGP enhances cell attachment and cell spreading on fibronectin. …”
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  14. 754

    Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

    Published 2023-12-01
    “…The hallmarks of cancer are a fundamental concept which aids the development of new means to treat human cancers through the understanding of the acquisition of these hallmarks from cells. Melittin is a major peptide component of bee venom which has shown to be efficacious as an anticancer agent in preclinical and animal models. …”
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  15. 755

    Antibody Mediated Transduction of Therapeutic Proteins into Living Cells by James E. Hansen, Richard H. Weisbart, Robert N. Nishimura

    Published 2005-01-01
    “…The most commonly used protein transduction domains are small cell-penetrating peptides derived from such proteins as the HIV-1 Tat protein. …”
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  16. 756

    Purification, Physicochemical Properties, and Epitope Analysis of Sarcoplasmic Calcium-Binding Protein from Penaeus vannamei by CHEN Wei, ZHOU Junjun, CHEN Yachun, JIA Yingmin, MA Aijin

    Published 2025-01-01
    “…The results showed that the purified protein, which was obtained by successive steps of crude protein extraction, ammonium sulfate fractionation and anion exchange chromatography and exhibited a molecular mass of 21.6 kDa, was identified as SCP with a peptide coverage of 93.26%. SCP had strong immunoactivity, which decreased during heat treatment (≥ 65 ℃) and under strongly acidic and alkaline conditions. …”
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    Article
  17. 757

    Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies by Aarat Patel, Georgia Seely, Rohit Aggarwal

    Published 2016-01-01
    “…Acthar® Gel (repository corticotropin injection [RCI]) is a melanocortin peptide that can induce steroid-dependent effects and steroid-independent effects. …”
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  18. 758

    Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis by Sundararajan Jayaraman, Arathi Jayaraman

    Published 2018-01-01
    “…Interestingly, administration of complete Freund’s adjuvant alone or emulsified with a neuronal peptide to induce neurodegenerative disease during the prediabetic stage completely prevented the onset of diabetes regardless of the pH of the drinking water. …”
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  19. 759

    Integrating TRPV1 Receptor Function with Capsaicin Psychophysics by Gregory Smutzer, Roni K. Devassy

    Published 2016-01-01
    “…TRPV1 receptors function as homotetramers that also respond to heat, proinflammatory substances, lipoxygenase products, resiniferatoxin, endocannabinoids, protons, and peptide toxins. Kinase-mediated phosphorylation of TRPV1 leads to increased sensitivity to both chemical and thermal stimuli. …”
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  20. 760

    Acute One-Cigarette Smoking Decreases Ghrelin Hormone in Saliva: A Pilot Study by Yahia A. Kaabi, Mohiealdeen A. Khalifa

    Published 2014-01-01
    “…Cigarette smoking is commonly associated with weight loss and mechanisms for these weight changes are still elusive. Ghrelin is a peptide hormone that works in a neuroendocrine fashion to stimulate hunger and the desire for food intake. …”
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