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741
Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction
Published 2025-02-01“…Pegmolesatide (by Hansoh Pharma) is currently the only marketed long-acting EPO mimetic peptide (EMP) for the treatment of anemia in both dialysis and non-dialysis CKD patients. …”
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742
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation
Published 2025-01-01“…This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, the sialic acid‐targeting peptide prolongs ocular surface retention, further enhancing therapeutic efficacy. …”
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743
In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment
Published 2025-01-01“…To mimic this property, a viscoelastic peptide bionic hydrogel named BCgel was developed, featuring a nanofiber network, Itgb1 binding affinity, BC-like viscoelasticity, and biosafety. …”
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744
Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration
Published 2008-01-01“…In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP), for its efficacy as an intravaginal microbicide. …”
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745
Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic
Published 2018-01-01“…By the age of 55, the patient no longer required any insulin and is currently being managed with metformin alone. C-peptide values indicate a functional improvement of the β-islet cells during the time of insulin/GABA/probiotic treatment.…”
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746
Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells
Published 1992-01-01“…TNF-α induced endothelin-1 gene expression was associated with a parallel increase in the release of the corresponding peptide in the culture medium. These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.…”
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747
Adropin as an indicator of T2DM and its complications
Published 2022-11-01“…Therefore, the prevention and treatment of T2DM and its complications has become an urgent problem to be solved. As a secreted peptide, adropin is identified as a useful regulator associated with insulin sensitivity and energy homeostasis. …”
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748
Angiotensin-Converting Enzyme 2: The First Decade
Published 2012-01-01“…The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin-converting enzyme (ACE) mediating an increase in blood pressure. …”
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749
Effectiveness and Safety of Newer Antidiabetic Medications for Ramadan Fasting Diabetic Patients
Published 2016-01-01“…New glucose-lowering classes like dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 receptor agonist (GLP-1 RA), and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are efficacious in controlling blood glucose level with less tendency to induce hypoglycemia and thus may constitute a good choice for diabetic patients during Ramadan. …”
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750
A molecular toolkit for heterologous protein secretion across Bacteroides species
Published 2024-11-01“…To understand the mechanistic drivers of Bacteroides secretion, we characterize signal peptide sequence features, post-secretion extracellular fate, and the size limit of protein cargo. …”
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751
Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat
Published 2014-09-01“…Right ventricular pressure, right ventricle mass and three biomarkers were evaluated after 21 days: brain natriuretic peptide, high-density lipoprotein cholesterol and vascular endothelial growth factor. …”
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752
Epitope mapping of recombinant Salmonella enterica serotype Heidelberg flagellar hook-associated protein by in silico and in vivo approaches
Published 2025-02-01“…The results show that both approaches identified three common shared consensus peptide epitope sequences at the positions of 77–95, 243–255 and 358–373 in the Salmonella serotype Heidelberg FlgK protein. …”
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753
Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin
Published 2014-01-01“…The binding site for fibronectin is in a MGP C-terminal peptide comprising amino acids 61–77. Second, MGP enhances cell attachment and cell spreading on fibronectin. …”
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754
Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy
Published 2023-12-01“…The hallmarks of cancer are a fundamental concept which aids the development of new means to treat human cancers through the understanding of the acquisition of these hallmarks from cells. Melittin is a major peptide component of bee venom which has shown to be efficacious as an anticancer agent in preclinical and animal models. …”
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755
Antibody Mediated Transduction of Therapeutic Proteins into Living Cells
Published 2005-01-01“…The most commonly used protein transduction domains are small cell-penetrating peptides derived from such proteins as the HIV-1 Tat protein. …”
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756
Purification, Physicochemical Properties, and Epitope Analysis of Sarcoplasmic Calcium-Binding Protein from Penaeus vannamei
Published 2025-01-01“…The results showed that the purified protein, which was obtained by successive steps of crude protein extraction, ammonium sulfate fractionation and anion exchange chromatography and exhibited a molecular mass of 21.6 kDa, was identified as SCP with a peptide coverage of 93.26%. SCP had strong immunoactivity, which decreased during heat treatment (≥ 65 ℃) and under strongly acidic and alkaline conditions. …”
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757
Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies
Published 2016-01-01“…Acthar® Gel (repository corticotropin injection [RCI]) is a melanocortin peptide that can induce steroid-dependent effects and steroid-independent effects. …”
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758
Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis
Published 2018-01-01“…Interestingly, administration of complete Freund’s adjuvant alone or emulsified with a neuronal peptide to induce neurodegenerative disease during the prediabetic stage completely prevented the onset of diabetes regardless of the pH of the drinking water. …”
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759
Integrating TRPV1 Receptor Function with Capsaicin Psychophysics
Published 2016-01-01“…TRPV1 receptors function as homotetramers that also respond to heat, proinflammatory substances, lipoxygenase products, resiniferatoxin, endocannabinoids, protons, and peptide toxins. Kinase-mediated phosphorylation of TRPV1 leads to increased sensitivity to both chemical and thermal stimuli. …”
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760
Acute One-Cigarette Smoking Decreases Ghrelin Hormone in Saliva: A Pilot Study
Published 2014-01-01“…Cigarette smoking is commonly associated with weight loss and mechanisms for these weight changes are still elusive. Ghrelin is a peptide hormone that works in a neuroendocrine fashion to stimulate hunger and the desire for food intake. …”
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