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  1. 721

    Solid-Phase Extraction Strategies to Surmount Body Fluid Sample Complexity in High-Throughput Mass Spectrometry-Based Proteomics by Marco R. Bladergroen, Yuri E. M. van der Burgt

    Published 2015-01-01
    “…Various sample preparation methods that involve solid-phase extraction (SPE) including affinity enrichment strategies have been automated. Obtained peptide and protein fractions can be mass analyzed by direct infusion into an electrospray ionization (ESI) source or by means of matrix-assisted laser desorption ionization (MALDI) without further need of time-consuming liquid chromatography (LC) separations.…”
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  2. 722

    Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema by Takuya Oyakawa, Keita Miura, Nao Muraoka, Kei Iida, Ayano Fujita, Tateaki Naito, Toshiaki Takahashi

    Published 2025-01-01
    “…In a patient with tepotinib‐induced edema and an N‐terminal pro‐brain natriuretic peptide (NTproBNP) level ≥ 300 pg/mL, the addition of empagliflozin to loop diuretics reduced the edema. …”
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  3. 723

    T Cell Costimulatory Molecules in Anti-Viral Immunity: Potential Role in Immunotherapeutic Vaccines by Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen

    Published 2003-01-01
    “…The activation of T cells requires both an antigen specific signal, involving the recognition of a peptide/major histocompatibility protein complex by the T cell receptor, as well as additional costimulatory signals. …”
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  4. 724

    The Effects of Affinity Mediated Clonal Expansion of Premigrant Thymocytes on the Periphery T-Cell Repertoire by Guanyu Wang

    Published 2004-10-01
    “…The immune system maintains a highly diverse T-cell repertoire,which is shaped by active interactions between developing thymocytesand endogenous peptide/MHC molecules through the principle ofpositive and negative selections. …”
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  5. 725

    Synaptic Cell Adhesion Molecules in Alzheimer’s Disease by Iryna Leshchyns’ka, Vladimir Sytnyk

    Published 2016-01-01
    “…Synaptic cell adhesion molecules interact with Aβ, a peptide accumulating in AD brains, which affects their expression and synaptic localization. …”
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  6. 726

    Association of preoperative blood biomarkers with postoperative major adverse cardiac events and mortality in major orthopaedic surgery: a systematic review and meta-analysis by Lin Lu, Yi Ren, Zhen Hua, Yanxia Sun, Zhenghao Wen, Suzhen Zhou

    Published 2025-01-01
    “…Only natriuretic peptide was associated with a high-risk long-term MACEs (>3 months) (OR 3.52, 95% CI 1.73 to 7.17, I2=86.2%). …”
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  7. 727

    Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes by Wiktor Biesiada, Ewelina Kopczyńska, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

    Published 2025-01-01
    “… Introduction Tirzepatide, a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has emerged as a transformative metabolic therapy with exceptional efficacy in weight management and glycemic control. …”
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  8. 728

    Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population by Iryna Kril, Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak

    Published 2025-01-01
    “…Peptides longer than 10 amino acids are trimmed by the endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 to fit the peptide binding groove of the HLA-I molecule. …”
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  9. 729

    Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

    Published 2023-06-01
    “…This has created a major challenge in understanding how CD11b converts the differences in the receptor-ligand binding into subsequent signaling responses and using this information for therapeutic development.Methods This study aimed to investigate the antitumor effect of a carbohydrate ligand, named BG34-200, which modulates the CD11b+ cells. We have applied peptide microarrays, multiparameter FACS (fluorescence-activated cell analysis) analysis, cellular/molecular immunological technology, advanced microscopic imaging, and transgenic mouse models of solid cancers, to study the interaction between BG34-200 carbohydrate ligand and CD11b protein and the resulting immunological changes in the context of solid cancers, including osteosarcoma, advanced melanoma, and pancreatic ductal adenocarcinoma (PDAC).Results Our results show that BG34-200 can bind directly to the activated CD11b on its I (or A) domain, at previously unreported peptide residues, in a multisite and multivalent manner. …”
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  10. 730

    Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy by Benjamin L. Franc, Stefanie J. Mandl, Zurab Siprashvili, Paul Wender, Christopher H. Contag

    Published 2003-10-01
    “…PTD imaging conjugates have included small molecules, peptides, proteins, DNA, metal chelates, and magnetic nanoparticles. …”
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  11. 731

    Protective Actions of PPAR-γ Activation in Renal Endothelium by Peter E. Westerweel, Marianne C. Verhaar

    Published 2008-01-01
    “…PPAR-γ-receptor activation stimulates the production of nitric oxide, C-type natriuretic peptide, and superoxide dismutase, while endothelin-1 production is inhibited. …”
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  12. 732

    Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules by Yang Gao, Jiexun Bu, Zhou Peng, Biwei Yang

    Published 2014-01-01
    “…Radical driven dissociation has been applied to a variety of biomolecules including peptides, nucleic acids, carbohydrates, and phospholipids. …”
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  13. 733

    Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases by Junmin Wang, Ning Ding, Chong Chen, Simin Gu, Jing Liu, Yanping Wang, Liubing Lin, Yiyuan Zheng, Yong Li

    Published 2025-01-01
    “…Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO), located chromosome 9p13.3, with a conserved amino acid sequence across humans and mice. …”
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  14. 734

    Local Bone Marrow Renin-Angiotensin System and Atherosclerosis by Yavuz Beyazit, Tugrul Purnak, Gulay Sain Guven, Ibrahim C. Haznedaroglu

    Published 2011-01-01
    “…Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. …”
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  15. 735

    Persistent Hypoglycemia in Patient with Hodgkin’s Disease by Harold Cinco Lim, Lubna Bashir Munshi, David Sharon

    Published 2015-01-01
    “…Hypoglycemia workup showed the C-peptide level to be low. Patient was suspected of having hypoglycemia related to lymphoma and was given a trial of prednisone which resolved the hypoglycemic episodes and made the patient euglycemic for the rest of his hospital stay. …”
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  16. 736

    Shedding light on the unseen: how live imaging of translation could unlock new insights in developmental biology by Dufourt, Jeremy, Bellec, Maelle

    Published 2024-09-01
    “…Among the various approaches to live imaging of translation, this perspective highlights the use of antibody-based nascent peptide detection, a method that enables visualization of single-molecule translation in vivo. …”
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  17. 737

    The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments by Bruna Bombassaro, Eliana P. Araujo, Licio A. Velloso

    Published 2025-01-01
    “…This has contributed to the characterization of the mechanisms by which glucagon-like peptide-1 receptor agonists promote body mass reduction and has opened new windows of opportunity for the development of drugs to treat obesity. …”
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  18. 738
  19. 739

    Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma by Jeannette C. Oosterwijk-Wakka, Liesbeth Houkes, Loes F.M. van der Zanden, Lambertus A.L.M. Kiemeney, Kerstin Junker, Anne Y Warren, Tim Eisen, Ulrich Jaehde, Marius T Radu, Rob Ruijtenbeek, Egbert Oosterwijk

    Published 2025-02-01
    “…Phosphotyrosine-activity profiling was performed using PamChip® peptide microarrays (144 peptides derived from known phosphorylation sites in Protein Tyrosine Kinase substrates) of lysed tissue samples (5 µg protein input) of 163 mRCC patients. …”
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  20. 740

    Potency of sponge-associated bacteria producing bioactive compounds as biological control of vibriosis on shrimp by Adityawati Fajar Rini, Munti Yuhana, Aris Tri Wahyudi

    Published 2017-07-01
    “…ABSTRACT   The aims of this study were to obtain sponge-associated bacteria as biocontrol to inhibit vibriosis in vitro and in vivo, to identify the bacterial isolates based on 16S-rRNA gene, and to detect the presence of nonribosomal peptide synthetase (NRPS), and polyketide synthase (PKS) genes to prove its ability of bioactive compounds synthesis. …”
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