Bone Turnover Markers in Adults with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis by Chao Li, Yali Cui, Wenjie Zhou, Yiduo Zhang, Xiaocui Huang, Fan Yu

“…The search formula is as follows: “nonalcoholic fatty liver disease” combined with the terms that bone turnover markers such as “osteocalcin,” “collagen type I trimeric cross-linked peptide,” and “procollagen type I N-terminal peptide.” …”
Get full text

Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2 by Niti Yashvardhini, Amit Kumar, Deepak Kumar Jha

“…Altogether, our study revealed that RdRp of SARS-CoV-2 (an epitope-based peptide fragment) can be a potentially good candidate for the development of a vaccine against SARS-CoV-2.…”
Get full text

Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy by Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg

“…These neoplasms are able to secrete a variety of bioactive amines or peptide hormones. The majority of NENs are well-differentiated and are defined as neuroendocrine tumors (NETs). …”
Get full text

Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation by Khalaf Reema Abu, Alwarafi Ebtisam, Sabbah Dima

“…Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the incretin levels, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic poly-peptide (GIP), leading to insulin secretion from pancreatic beta cells. …”
Get full text

Chemo-selective modification of cysteine residue: synthesis and application in the discovery of potential drug candidates by Yanyan Liao, Xuefeng Jiang

“…Chemo-select modification of peptides, targeting a handful of the most reactive proteinogenic amino acids (AAs), is gradually utilized to address the medical needs of peptide drugs and biopharmaceuticals. …”
Get full text

Factors Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus by Bin-Bin He, Li Wei, Yun-Juan Gu, Jun-Feng Han, Ming Li, Yu-Xiang Liu, Yu-Qian Bao, Wei-Ping Jia

“…Negative correlations were found between DR and C-peptide and glomerular filtration rate. Logistic regression analysis revealed that duration of diabetes, SBP, DN, anemia, PA, and C-peptide were each independent risk factors of DR. …”
Get full text

Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer by Binyu Zhu, Ying Cai, Lingli Zhou, Lei Zhao, Jiameng Chen, Xiaoting Shan, Xujie Sun, Qian You, Xiang Gong, Wen Zhang, Helen He Zhu, Pengcheng Zhang, Yaping Li

“…Herein, we create an abemaciclib-loaded supramolecular peptide hydrogel formed by peptide-drug amphiphiles for neoadjuvant immunotherapy of triple-negative breast cancer, where the amphiphile is a conjugate of a β-sheet-forming peptide with 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919), an inhibitor of indoleamine 2,3-dioxygenase 1. …”
Get full text

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…Injection of melanoma-derived peptides induces T cell responses; however, the depots that form following injection may inhibit optimization of the immune response. …”
Get full text

Role Of Cgrp In Sensitization Of Dura Mater by K. Messlinger

“…The mammalian dura mater encephali is richly supplied by trigeminal nerve fibers, a considerable proportion of which contains calcitonin gene-related peptide (CGRP). As plasma levels of CGRP are increased in some forms of headaches, the question is in which way CGRP is involved in nociceptive mechanisms within the peripheral and the central trigeminovascular system.…”
Get full text

Biomarkers as Diagnostic and Prognostic Tools in Cardiac Disorders: A Comprehensive Review by Rabinarayan Parhi, Goutam Kumar Jena, Chinam Niranjan Patra, Sruti Jammula

“…Among the well-established biomarkers, cardiac troponins (cardiac troponin I and cardiac troponin T) exhibit high sensitivity and specificity in the detection of myocardial infarction, and recent advances have improved early diagnosis and risk evaluation. B-type natriuretic peptide and its precursor N-terminal pro-B-type natriuretic peptide play critical roles in the diagnosis and management of heart failure; elevated levels of these factors indicate poor prognosis and can guide therapeutic decision-making. …”
Get full text

B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody by Darel Martínez, Amaury Pupo, Lianet Cabrera, Judith Raymond, Nichol E. Holodick, Ana María Hernández

“…Using bioinformatics, a MHC class I-binding peptide from P3 VH region was identified. P3 mAb was able to induce a specific CTL response in vivo against cells presenting this peptide. …”
Get full text

Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions by Miranda Movahed, Ruy A. Louzada, Manuel Blandino-Rosano

“…Objective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells. …”
Get full text

Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers by Zhenyu Qian, Yan Jia, Guanghong Wei

“…Peptide-lipid interaction analyses show that the different binding features of hIAPP at POPC and POPG bilayers are attributed to different magnitudes of electrostatic and hydrogen-bonding interactions with lipids. …”
Get full text

Characterization of Human Colorectal Cancer MDR1/P-gp Fab Antibody by Xuemei Zhang, Gary Guishan Xiao, Ying Gao

“…In this study, the peptide sized 21 kDa covering P-gp transmembrane region was first prepared for generating a novel mouse monoclonal antibody Fab fragment with biological activity against multiple drug resistance protein P-gp21 by phage display technology. …”
Get full text

Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An In Vitro Study by Nermeen El-Moataz Bellah Ahmed, Masashi Murakami, Yujiro Hirose, Misako Nakashima

“…Moreover, treatment with DPSC secretome significantly decreased the cytotoxicity of Aβ peptide by increasing cell viability compared to nontreated cells. …”
Get full text

Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4 by Zheng-Cai Jia, Bing Ni, Ze-Min Huang, Yi Tian, Jun Tang, Jing-Xue Wang, Xiao-Lan Fu, Yu-Zhang Wu

“…MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials. …”
Get full text

Drug discovery: a multifactorial ecosystem by Fernando Albericio

Get full text

Human Islet Amyloid Polypeptide Fibril Binding to Catalase: A Transmission Electron Microscopy and Microplate Study by Nathaniel G. N. Milton, J. Robin Harris

“…Fibrils formed by the PrP 118-135 peptide with a Gly-Ala-Val-Val sequence also bound catalase. …”
Get full text

Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis by Jessica Anne Douglas, Kevin Deighton, Jan Maria Atkinson, Vahid Sari-Sarraf, David John Stensel, Greg Atkinson

“…In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. …”
Get full text

The Effects of C. lacerata on Insulin Resistance in Type 2 Diabetes Patients by Arim Choi, Jung Hye Kim, Hye-Kyung Chung, Chul Woo Ahn, Hee Joon Choi, Yu-Sik Kim, Ji Sun Nam

“…Fasting, postprandial c-peptide, and insulin levels decreased at week 12 in the C. lacerata group (p<0.05). …”
Get full text