Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

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Screening and evaluation of novel DPP-IV inhibitory peptides in goat milk based on molecular docking and molecular dynamics simulation by Kuo Dang, Jing Lan, Yanli Wang, Daodong Pan, Lihui Du, Shikun Suo, Yali Dang, Xinchang Gao

“…Virtual screening techniques have gained much attention as a means of studying bioactive peptides. This study aimed to screen DPP-IV inhibitor peptides in goat milk after simulated digestion in vitro combined with molecular docking and dynamics simulations. …”
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Extraction of Antioxidant Peptides and Activity Evaluation of Frog (Rana nigromaculata) Skin by Ultra-high Pressure Assisted Enzyme Hydrolysis by Xicai ZHANG, Rong LI, Yechuan HUANG

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Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling by Yasuhiro Izumiya, Satoshi Araki, Hiroki Usuku, Taku Rokutanda, Shinsuke Hanatani, Hisao Ogawa

“…Myocardial oxidative stress and inflammation are key mechanisms in cardiovascular remodeling. C-type natriuretic peptide (CNP) is an endothelium-derived cardioprotective factor, although its effect on cardiac superoxide generation has not been investigated in vivo. …”
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Nutritional properties of Europen eel (Anguilla anguilla) bone peptide-calcium and its apoptosis effect on Caco-2 cells by Hui Teng, Yuewei Qian, Xiaoyun Fan, Hui Cao, Yuting Tian, Lei Chen

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Peptide P2 targeting Vibrio parahaemolyticus PirB toxins blocks the cytotoxic effects to shrimp Litopenaeus vannamei by Xin Zhang, Ting Chen, Chunhua Ren, Yanhong Wang, Xiao Jiang, Jiasheng Huang, Bo Ma, Boxiang Zhu, Jiayue Yin, Chaoqun Hu, Peng Luo

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Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies by Jacinta Cheng, Tia Solomon, Mahnuma Estee, Flavia M. Cicuttini, Yuan Z. Lim

“…Objective: There is significant interest in the potential of glucagon-like peptide 1 receptor agonists (GLP-1A) to improve outcomes in osteoarthritis. …”
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Identification of novel saltiness/saltiness enhancing peptides in egg proteins: Molecular docking, action mechanism and in vitro activity validation by Yaxin Cao, Linyuezhi Yan, Di Liu, Qian Zhang, Wenzhu Zhao, Lin Yuan, Yiding Yu, Zhipeng Yu

Subjects: “…Saltiness/saltiness enhancing peptides…”
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Immunization with a Synthetic Helicobacter pylori Peptide Induces Secretory IgA Antibodies and Protects Mice against Infection by David Espinosa-Ramos, Diana Caballero-Hernández, Ricardo Gomez-Flores, Armando Trejo-Chávez, Luis Jerónimo Pérez-Limón, Myriam Angélica de la Garza-Ramos, Reyes Tamez-Guerra, Patricia Tamez-Guerra, Cristina Rodriguez-Padilla

“…MVTLINNE peptide deserves further research as an approach to the prophylaxis of H. pylori infection.…”
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Reduced Serum Glucagon Like Peptide-1 In Children with Osteoporosis of Chronic Liver Diseases: A Single Center Trial by Nashwa F. Mohamed Elmetwaly, Ola G. Behairy, Manal S. EL-Defrawy, Ola E. Seleim, Dina S. Abdelmotaleb

“…Background: Chronic liver disease (CLD) in children is associated with reduction of bone mineral density. Glucagon like peptide- 1 (GLP-1) is essential for bone metabolism and bone turnover. …”
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Novel insight into the formation and inhibition mechanism of dipeptidyl peptidase-Ⅳ inhibitory peptides from fermented mandarin fish (Chouguiyu) by Daqiao Yang, Chunsheng Li, Laihao Li, Xianqing Yang, Shengjun Chen, Yanyan Wu, Yang Feng

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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…The ELISpot assay showed that the IL17A peptide-based vaccine did not elicit any IL17A-reactive T cell responses. …”
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Novel soybean peptide iglycin ameliorates insulin resistance of high-fat diet fed C57BL/6J mice and differentiated 3T3L1 adipocytes with improvement of insulin signaling and mitochondrial function by Yinghuan Wu, Ran Zhao, Minxia Li, Huiyun Li, Zhengwang Chen, Yanying Zhao

Subjects: “…Soybean peptide…”
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Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatograp... by Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan

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Impact of sodium alginate hydrogel containing bacteriophage peptides that specifically bind to the EtCab protein on the inhibition of Eimeria tenella infection by Hang Chen, Wenjing Zhi, Bingrong Bai, Faisal R. Anjum, Zhipeng Jia, Rui Kong, Qiuju Liu, Biao Wang, Chunli Ma, Dexing Ma

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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptides immunotherapy): study protocol for an open-label, non-randomised, prospective, single-arm trial by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Through the whole exome and transcriptome sequencing analysis of the fresh blood and tumour tissues of the enrolled patients, the 20 25-33aa antigen peptides with the highest mutation scores of the patients will be screened out, and the corresponding new antigen peptides will be synthesised and prepared. …”
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Comparing the difference in enhancement of kokumi-tasting γ-glutamyl peptides on basic taste via molecular modeling approaches and sensory evaluation by Juan Yang, Jing Guo, Ruijie Mai, Hao Dong, Chun Cui, Xiaofang Zeng, Weidong Bai

Subjects: “…γ-Glutamyl peptides Taste-enhancing effect Molecular mechanism Taste type 1 receptor 1 Taste type 1 receptor 2…”
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Branched-Chain Amino Acid (BCAA) Oligopeptide Determination from Whey Proteins: Preparation, Peptide Profiles, and Anti-Fatigue Activity by Qiong Zhu, Renjie Zhou, Xiping Zhu, Xiangru Lu, Binli Ai, Qibin Zhuang, Chun Cui

“…Fraction D’ was found to contain the highest content of BCAAs and a high proportion of low-molecular-weight peptides (<1 kDa; content: 81.48%). Subsequently, mass spectrometry identified 15 BCAA oligopeptides in Fraction D’, including three dipeptides, six tripeptides, two tetrapeptides, and four pentapeptides. …”
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Interaction mechanism of egg white- derived ACE inhibitory peptide TNGIIR with ACE and its effect on the expression of ACE and AT1 receptor by Zhipeng Yu, Hui Guo, David Shiuan, Chensi Xia, Wenzhu Zhao, Long Ding, Fuping Zheng, Jingbo Liu

“…Keywords: Egg white proteins, ACE inhibitory peptide, Gene expression, Antihypertensive effect, Molecular docking…”
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Immunization of cattle with a Rhipicephalus microplus chitinase peptide containing predicted B-cell epitopes reduces tick biological fitness by María Martina Esperanza Perez-Soria, Daniel Gustavo López-Díaz, Rafael Jiménez-Ocampo, Gabriela Aguilar-Tipacamú, Massaro W. Ueti, Juan Mosqueda, Ala Tabor

“…The immunogenicity of each peptide was assessed by inoculating 2 cattle, 4 times at 21 days intervals, and the antibody response was verified by indirect ELISA. …”
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