Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease by Marilena K. Theodoropoulou, Konstantina D. Vraila, Nikos C. Papandreou, Georgia I. Nasi, Vassiliki A. Iconomidou

“…The peptide analogs of co-localized protease, Cathepsin B, may act as such potent inhibitors. …”
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The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response. by Tania Veuthey, Jeremy T Florman, Sebastián Giunti, Stefano Romussi, María José De Rosa, Mark J Alkema, Diego Rayes

“…In Caenorhabditis elegans, DAF-2/IIS signaling is modulated by an extensive array of insulin-like peptides (ILPs) with diverse spatial and temporal expression patterns. …”
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Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

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Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer by Katsushi Takeda, Ryosuke Kimura, Nobuhiro Nishigaki, Shinya Sato, Asami Okamoto, Kumiko Watanabe, Sachie Yasui

“…Humoral hypercalcemia of malignancy (HHM) is caused by the oversecretion of parathyroid hormone-related peptide (PTHrP) from malignant tumors. Although any tumor may cause HHM, that induced by intrahepatic cholangiocarcinoma (ICC) or gastric cancer (GC) is rare. …”
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A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1 by Zhen Zhang, Yinghui Hu, Ningning Xu, Wenjun Zhou, Lei Yang, Rongping Chen, Rui Yang, Jia Sun, Hong Chen

“…Exposure to glucagon-like peptide 1 (GLP1) can ameliorate hyperglycemia in diabetic mice and restore the beta cell mass. …”
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Cytological evaluation by Caco-2 and KU812 of non-allergenic peptides from simulated digestion of infant formula in vitro by Zihao Xu, Hao Bai, Xin Ma, Yong Wu, Zhihua Wu, Anshu Yang, Weixiang Mao, Xin Li, Hongbing Chen

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Practical Tips for Construction of Custom Peptide Libraries and Affinity Selection by Using Commercially Available Phage Display Cloning Systems by Keisuke Fukunaga, Masumi Taki

“…In the M13 system, Pro or a basic amino acid (especially, Arg) should be avoided at the N-terminus of peptide fused to gp3. In both systems, peptides containing odd number(s) of Cys should be designed with caution. …”
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Type III procollagen peptide level can indicate liver dysfunction associated with volume overload in acute heart failure by Akihiro Shirakabe, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Shota Shigihara, Suguru Nishigoori, Tomofumi Sawatani, Nozomi Sasamoto, Kazutaka Kiuchi, Masanori Atsukawa, Norio Itokawa, Taeang Arai, Nobuaki Kobayashi, Kuniya Asai

“…Abstract Aim The role of serum type III procollagen peptide (P3P) level in the acute phase of acute heart failure (AHF) requires clarification. …”
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Possible Involvement of Endothelin Peptides and L-Arginine-Nitric Oxide Pathway on the Effect of Endotoxin in the Rabbit Isolated Perfused Kidney by K. Özsan, R. K. Türker, Z. S. Ercan

“…These results were taken as evidence for the participation of endothelin peptides and the L-arginine-nitric oxide pathway in the effect ofLPS in rabbit isolated perfused kidney.…”
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Validation of a B-type natriuretic peptide as a prognostic marker in pneumonia patients: a prospective cohort study by Yu Hashimoto, Daisuke Usuda, Ryusho Sangen, Emiri Muranaka, Yoshitsugu Iinuma, Tsugiyasu Kanda

“…Objectives To validate a B-type natriuretic peptide (BNP) as a prognostic marker in pneumonia patients.Design A prospective cohort study.Setting Kanazawa Medical University Himi Municipal (a 250-bed community hospital in Himi-shi, Toyama-ken, Japan).Participants All patients diagnosed with pneumonia by the physician and admitted to our hospital between 1 January 2012 and 31 March 2015 whose BNP levels had been determined in the first 24 h of admission. …”
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Purification of Angiotensin-I-Converting Enzyme Inhibitory Peptides Derived from Camellia oleifera Abel Seed Meal Hydrolysate by Guang-long Yao, Wei He, You-gen Wu, Jian Chen, Xin-wen Hu, Jing Yu

“…Ultrafiltration, gel chromatography, and RP-HPLC purification were conducted for ACE inhibitory peptides, and peptide molecular weight distribution and amino acid composition were analyzed in the enzymolysis liquid. …”
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Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor by Claire Lacombe, Estefania Aleman-Navaro, Thierry Drujon, Veronica Martinez-Osorio, Emmanuelle Sachon, Erika Melchy-Pérez, Ludovic Carlier, Lorena Elizabeth Fajardo Brigido, Yannick Fleury, Christophe Piesse, Guadalupe Gutiérrez-Escobedo, Alejandro De las Peñas, Irene Castaño, Florie Desriac, Jose Luis Beristain-Hernandez, Christophe Combadiere, Yvonne Rosenstein, Constance Auvynet

“…We isolated three forms (DRS-DA2N, DRS-DA2NE, and DRS-DA2NEQ) of the same peptide, DRS-DA2, which belongs to the dermaseptin family, from the Mexican tree frog Pachymedusa dacnicolor. …”
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Identification of egg protein-derived peptides as xanthine oxidase inhibitors: virtual hydrolysis, molecular docking, and in vitro activity evaluation by Zhipeng Yu, Yaxin Cao, Ruotong Kan, Huizhuo Ji, Wenzhu Zhao, Sijia Wu, Jingbo Liu, David Shiuan

Subjects: “…Egg protein-derived peptides…”
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Antibacterial and antibiofilm activity of peptide PvGBP2 against pathogenic bacteria that contaminate Auricularia auricular culture bags by Shen Yang, Zijin Yuan, Jude Juventus Aweya, Shanggui Deng, Wuyin Weng, Yueling Zhang, Guangming Liu

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Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine by Maysa F. Zampa, Inês Maria de S. Araújo, José Ribeiro dos Santos Júnior, Valtencir Zucolotto, José Roberto de S. A. Leite, Carla Eiras

“…This work is the first to report that the antimicrobial peptide and NiTsPc LbL film exhibits electroanalytical activity to DA oxidation. …”
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Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus by Yan Yang, Chao Yuan, Shu-qun Shen, Xue-er Wang, Qing-hua Mei, Wen-qing Jiang, Qin Huang

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Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides by Na Qiang, Shuo Tang, Xiang Liao, Hao Liang, Fang Xie, Ji-xiang Zhu

“…The small peptide was beneficial to the axon growth of PC12 cells.…”
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Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus by Utpal Kumar Adhikari, Mourad Tayebi, M. Mizanur Rahman

“…Collectively, this research provides novel candidates for epitope-based peptide vaccine design against OROV.…”
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Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

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Screening and evaluation of novel DPP-IV inhibitory peptides in goat milk based on molecular docking and molecular dynamics simulation by Kuo Dang, Jing Lan, Yanli Wang, Daodong Pan, Lihui Du, Shikun Suo, Yali Dang, Xinchang Gao

“…Virtual screening techniques have gained much attention as a means of studying bioactive peptides. This study aimed to screen DPP-IV inhibitor peptides in goat milk after simulated digestion in vitro combined with molecular docking and dynamics simulations. …”
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