Engineering of acyl ligase domain in non-ribosomal peptide synthetases to change fatty acid moieties of lipopeptides by Rina Aoki, Eri Kumagawa, Kazuaki Kamata, Hideo Ago, Naoki Sakai, Tomohisa Hasunuma, Naoaki Taoka, Yukari Ohta, Shingo Kobayashi

“…Abstract Cyclic lipopeptides (CLPs) produced by the genus Bacillus are amphiphiles composed of hydrophilic amino acid and hydrophobic fatty acid moieties and are biosynthesised by non-ribosomal peptide synthetases (NRPSs). CLPs are produced as a mixture of homologues with different fatty acid moieties, whose length affects CLP activity. …”
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Direct visualization of peptide/MHC complexes at the surface and in the intracellular compartments of cells infected in vivo by Leishmania major. by Eric Muraille, Pierre Gounon, Julie Cazareth, Johan Hoebeke, Christoph Lippuner, Ana Davalos-Misslitz, Toni Aebischer, Sylviane Muller, Nicolas Glaichenhaus, Evelyne Mougneau

“…To directly visualize the antigen presenting cells that present parasite-derived peptides to CD4+ T cells, we have generated a monoclonal antibody that reacts to an antigenic peptide derived from the parasite LACK antigen bound to I-Ad Major Histocompatibility Complex class II molecule. …”
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Engineering of L-Plastin Peptide-Loaded Biodegradable Nanoparticles for Sustained Delivery and Suppression of Osteoclast Function In Vitro by Sunipa Majumdar, Aniket S. Wadajkar, Hanan Aljohani, Mark A. Reynolds, Anthony J. Kim, Meenakshi Chellaiah

“…We have recently demonstrated that a small molecular weight amino-terminal peptide of L-plastin (10 amino acids; “MARGSVSDEE”) suppressed the phosphorylation of endogenous L-plastin. …”
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Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection by Gokhan Sargin, Altay Kandemir

“…Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) may be detected in rheumatic diseases and also during infections. …”
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A comprehensive method to explore inhibitory kinetics and mechanisms of an anticoagulant peptide derived from Crassostrea gigas by Shuzhen Cheng, Di Wu, Hanxiong Liu, Xianbing Xu, Beiwei Zhu, Ming Du

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Publisher Correction: The NIN transcription factor coordinates CEP and CLE signaling peptides that regulate nodulation antagonistically by Carole Laffont, Ariel Ivanovici, Pierre Gautrat, Mathias Brault, Michael Anthony Djordjevic, Florian Frugier

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Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum by Alessandra Puddu, Roberta Sanguineti, Arianna Durante, Alessio Nencioni, François Mach, Fabrizio Montecucco, Giorgio L. Viviani

“…AGEs negatively affect pancreatic beta-cell function and the expression of transcriptional factors regulating insulin gene. Glucagon-like peptide-1 (GLP-1), an incretin hormone that regulates glucose homeostasis, might counteract the harmful effects of AGEs on the beta cells in culture. …”
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The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding by Simon Malte Lauer, Jakob Gasse, Andor Krizsan, Maren Reepmeyer, Thiemo Sprink, Rainer Nikolay, Christian M. T. Spahn, Ralf Hoffmann

“…Abstract The proline-rich antimicrobial designer peptide Api137 inhibits protein expression in bacteria by binding simultaneously to the ribosomal polypeptide exit tunnel and the release factor (RF), depleting the cellular RF pool and leading to ribosomal arrest at stop codons. …”
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Pipeline for development of acylated peptide based CGRP receptor antagonist with extended half-life for migraine treatment by Jens Bjelke Kristensen, Lisbeth Elster, Morten Lundh, Borja Ballarín-González, Flora Alexopoulou, Martin Kræmer, Ditte Marie Jensen, Ulrike Leurs, Jens Christian Nielsen, Henrik H. Hansen, Kristian A. Haanes, Matilda Degn

“…Here, we present a pipeline for development of a peptide-based hCGRP receptor antagonist with increased half-life capable of antagonising the vasodilatory effect of hαCGRP. …”
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Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application by Xiaoping Leng, Jianjun Wang, Andrew Carson, Xucai Chen, Huili Fu, Susanne Ottoboni, William R. Wagner, Flordeliza S. Villanueva

“…Biodegradable polymer MBs were prepared bearing a peptide with specific human E-selectin affinity (MB ESEL ). …”
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Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes by Aika Miya, Akinobu Nakamura, Hiroshi Nomoto, Hiraku Kameda, Tatsuya Atsumi

“…The proinsulin-to-C-peptide (PI:C) ratio is an index applied during the early stage of pancreatic β-cell dysfunction. …”
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Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma by Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi

“…Computational assessments were performed on these chimeric vaccines for antigenicity, allergenicity, peptide toxicity, population coverage, and physicochemical properties. …”
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Effects of Retinol, Natural Pea Peptide and Antioxidant Blend in a Topical Formulation: In Vitro and Clinical Evidence by Brian Cook, Melanie Riggs, K. C. Holley, Helen Knaggs, Ganesh Diwakar, Edwin D. Lephart

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Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design by Muhammad Umar, Haroon Afzal, Asad Murtaza, Li-Ting Cheng

“…This lipidation is guided by bacterial signal peptides (SPs), which ensure the precise targeting and membrane anchoring of these proteins. …”
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HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design by Amy L. Kessler, Roel F. A. Pieterman, Wouter A. S. Doff, Karel Bezstarosti, Rachid Bouzid, Kim Klarenaar, Diahann T. S. L. Jansen, Robbie J. Luijten, Jeroen A. A. Demmers, Sonja I. Buschow

“…Abstract Synthetic long peptides (SLPs) are a promising vaccine modality that exploit dendritic cells (DC) to treat chronic infections or cancer. …”
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Estimation of calcitonin and calcitonin gene-related peptide-α in bone calcification in quail during laying period by Hadeel M. Hameed, Soulaf J. Kakel

“…The outcomes of the study indicate an elevation in the level of calcium and calcitonin during the peak and final period of egg production, followed by a rise in the quantity of gene-related peptide-α during the final period of egg laying, with a strong positive relationship between the level of phosphorus and calcium, as well as between gene-related peptide-α and calcitonin during the peak and final period of egg production. …”
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A bird’s-eye view of the biological mechanism and machine learning prediction approaches for cell-penetrating peptides by Maduravani Ramasundaram, Honglae Sohn, Thirumurthy Madhavan

Subjects: “…cell-penetrating peptides…”
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Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway by Kai Fang, Christopher G. Kevil

“…AP-Cav significantly blunted VEGF-dependent extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation at 10 minutes and 2 hours after stimulation, compared with the AP control peptide. AP-Cav + VEGF-A treatment also significantly increased c-Jun N-terminal kinase (JNK) phosphorylation at 2 hours. …”
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Hypercalcemia in Small Lymphocytic Lymphoma with an Elevated Parathyroid Hormone-Related Peptide Associated with Early Richter Transformation by Ashish Bains, Pedro Covas, Olga Timofeeva, Michael Bromberg

“…We report a case of small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) associated with hypercalcemia and an elevation in parathyroid hormone-related peptide (PTHrP) in the setting of a Richter transformation. …”
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Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I by Bryan Neumann, Stephen McCarthy, Shane Gonen

“…One such inhibitor, the gating-modifier peptide Protoxin-I derived from tarantula venom, blocks channel opening by shifting the activation voltage threshold to more depolarized potentials, but the structural basis for this inhibition has not previously been determined. …”
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