Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication by Sara Memarian, Behdad Gharib, Mohammd Gharagozlou, Hosein Alimadadi, Zahra Ahmadinejad, Vahid Ziaee

“…Nicolau syndrome (NS) or livedo-like dermatitis is a rare complication of injection of various medications such as penicillin. The pathophysiology of this events is not clear, but some hypotheses are suggested, such as sympathetic nerve stimulation, embolic occlusion, inflammation, or mechanical injury. …”
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Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis by Stefanie Leimbach, Franziska Nankemann, Anne Tellen, Doris Klocke, Nicole Wente, Yanchao Zhang, Volker Krömker

“…While in some countries, cases of mild and moderate mastitis are treated almost completely with simple penicillin, in other countries, penicillin is rarely used as a mono-substance in udder tubes. …”
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Penicillin Susceptibility and Macrolide-Lincosamide-Streptogramin B Resistance in Group B Streptococcus Isolates from a Canadian Hospital by Kevin Sherman, Sue Whitehead, Edith Blondel-Hill, Ken Wagner, Naowarat Cheeptham

“…Decreased susceptibility to penicillin G has occasionally been reported; however, clindamycin and erythromycin resistance is on the rise and is causing concern over the use of clindamycin and erythromycin IAP.…”
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Acceptability and Implementation Challenges of Benzathine Penicillin G Secondary Prophylaxis for Rheumatic Heart Disease in Ethiopia: A Qualitative Study by Eshetie Melese Birru, Kevin T. Batty, Laurens Manning, Stephanie L. Enkel, Brioni R. Moore

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Studies on the penicillin- resistance with same enzyme characteristics and biochemicaı tests of staph. aureus isolated from cows milk with mastitis by İ. Yavuz SEZEN, Osman ERGANİŞ, Mehmet ÇORLU, Mehmet ATEŞ

“…Nineteen strains of Staph. aureus isolated from cows milk with mastitis were tested for their ability to produce coagulase, phosphatase, catalase, B-lactamase, clumping factor, oxydation/fermentcı. tion (O/F) and resistance of penicillin and ampicillin.<p> All of the strains have produced B-lactamase and their resistance rates to penicillin and ampicillin were 94.9%, 47.9% respectively. …”
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Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice by Sarah Tonkin-Crine, Robert West, Sinisa Savic, Jonathan Sandoe, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Sue H Pavitt, Philip Howard, Catherine Porter, Mandy East, Marta Santillo, Louise Savic, Joanne Fielding, Jenny Boards, Catherine E Porter, Jonathan AT Sandoe

“…Objectives About 6% of the UK general practice population has a record of a penicillin allergy but fewer than 10% of these are likely to be truly allergic. …”
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Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis by Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz

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Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient by Jamie Dietze, Shane Havens

“…This report summarizes the presentation, management, and clinical course of a patient with known HIV and penicillin allergy that presented with bilateral optic nerve edema, retinal hemorrhages, and iritis without vision loss.…”
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Molecular Characterization of Methicillin Resistant and Extended Spectrum ?-Lactamase Staphylococcus aureus Isolated from Burn Patients by Shawnm Ahmed Aziz

Subjects: “…Methicillin Resistance Staphylococcus aureus, Extended Spectrum Beta Lactamase, Vancomycin, Penicillin Binding Proteins.…”
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Does macrolide use confer risk of out-of-hospital cardiac arrest compared with penicillin V? A Danish national case-crossover and case–time–control study by Lars Køber, Freddy Lippert, Charlotte Andersson, Peter E Weeke, Gunnar H Gislason, Frederik Boetius Hertz, Aksel Jensen, Jenny D Knudsen, Magnus Arpi, Christian Torp–Pedersen

“…Of these, 514 were in macrolide treatment ≤7 days before OHCA and 1237 in penicillin-V treatment.Results In the case-crossover analyses, overall macrolide use was not associated with OHCA with penicillin V as negative comparative reference (OR=0.90; 95% CI 0.73 to 1.10). …”
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Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from Natural Flavonoids by Motahareh Masumi, Fatemeh Noormohammadi, Fatemeh Kianisaba, Fatemeh Nouri, Mohammad Taheri, Amir Taherkhani

“…Methicillin-resistant S. aureus (MRSA) contains penicillin-binding protein 2a (SauPBP2a) responsible for catalyzing the peptidoglycan production within the bacterial cell wall. …”
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<i>Tribulus terrestris</i> Fruit Extract: Bioactive Compounds, ADMET Analysis, and Molecular Docking with Penicillin-Binding Protein 2a Transpeptidase of Methicillin-Resistant <i>Staphylococcus epidermidis</i> by Khalid J. Alzahrani

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Community-Acquired Methicillin-Resistane Staphylococcus aureus: Getting over It by LE Nicolle

“…Staphylococcus aureus has always been a poster child for the emergence of antimicrobial resistance (1). Penicillin-resistant strains of S aureus surfaced immediately following the introduction of penicillin in the late 1940s; within a few years, most hospital strains were penicillin resistant. …”
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A Rare Case of Neurosyphilis with Calvaria Osteitis Presenting in Pregnancy by Gisella M. Newbery, Christine E. Henricks, Julie A. Vircks, Andreina Colina, David C. Mundy

“…She completed 14 days of intravenous aqueous crystalline penicillin G with additional benzathine penicillin G 2.4 million units intramuscular weekly for two weeks. …”
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Serotypes and antimicrobial resistance of Streptococcus pneumoniae in Chinese pediatric population: a scoping review by Xu Han, Haiyang Yu, Niurka Molina Águila, María Eugenia Toledo Romaní

“…There are 11 articles that analyze the antimicrobial resistance of Streptococcus pneumoniae, the prevalence of non-susceptible to penicillin is in the range of 0% to 95.7%. Isolates are highly resistant to erythromycin, clindamycin, tetracycline, and trimethoprim-sulfamethoxazole; they are resistant to penicillin in pneumococcal meningitis but are sensitive to penicillin in other pneumococcal diseases, in addition, they are very sensitive to levofloxacin, vancomycin and Linezolid. …”
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Synthesis, characterization and evaluation biological activity of some 2-mercaptobinzemidazol complexes by Anfal Salam Al-Mahdawi, Noor Sabah Al-Obaidi, Amna Ali Ahmad, Tabarak Ali Jumaa, Zahraa Ali Abas, Haider Salah Mahdi

“…The synthesized complexes were assessed for their biological activity against different four types of bacteria (Staphylococcus aureus, Escherichia coli, spherical bacteria, Staphylococcus epidermidis, and Klebsiella pneumoniae), in addition to a type of Fungus, Candida albicans, the comparison include the activity of the complexes in relation to the antibiotic penicillin and the activity of 2-mercaptobenzomidazole, the prepared complexes had the highest biological activity compared to ligand and the antibiotic penicillin, the best prepared complex was the cadmium complex, the diameter of inhibition ranged between (27–36 nm) against bacteria and (40 nm) against the fungus, the complexes can be suggested as a more activity antibiotic than ligand and penicillin.…”
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First Reported Case of Bacterial Endocarditis Attributable to Actinomyces meyeri by Susan Moffatt, A Raza Ahmen, Kevin Forward

“…The patient completed a six-week course of penicillin and was doing well three months after surgery. …”
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Where are all the new antibiotics? The new antibiotic paradox by JM Conly, BL Johnston

“…Penicillin came into widespread use during the early 1940s. …”
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Propionibacterium acnes: A Treatable Cause of Constrictive Pericarditis by Daniel Cruz, Haitham Ahmed, Yousuf Gandapur, M. Roselle Abraham

“…We believe that further studies are needed to assess prevalence of P. acnes and response to intravenous Penicillin G in patients presenting with effusive constrictive disease.…”
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Evidence of vancomycin-resistant Staphylococcus aureus, multidrug-resistant S. aureus, and Enterococcus faecium-causing mastitis in Thailand and Cambodia by Sambo Na, Montira Intanon, Anyaphat Srithanasuwan, Wasana Chaisri, Witaya Suriyasathaporn

“…Three isolates were identified as multidrug-resistant (MDR), resistant to tetracycline, gentamycin, and penicillin. E. faecium isolates exhibited high resistance to tetracycline (100%) and penicillin (90%), with 60% classified as MDR. …”
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