Evaluation of oral cholera vaccine (Euvichol-Plus) effectiveness against Vibrio cholerae in Bangladesh: an interim analysis by Amanda Tiffany, Ashraful Islam Khan, Firdausi Qadri, John D Clemens, Faisal Ahmmed, Farhana Khanam, Tahmina Shirin, Fahima Chowdhury, Md. Taufiqul Islam, Md Nazmul Islam, Md Nazmul Hasan Rajib, Md Ismail Hossen, Md. Taufiqur Rahman Bhuiyan, Shahinur Haque, Prasanta Kumar Biswas, Amirul Islam Bhuiyan, Zahid Hasan Khan, Mohammad Ashraful Amin, Aninda Rahman, S M Shahriar Rizvi, Lucy Breakwell

“…We conducted systematic surveillance in two key facilities, enrolling patients with acute watery diarrhoea who were eligible for vaccination from the campaign’s start and who presented for care between 21 August 2022 and 20 August 2023. …”
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Germline Single-Nucleotide Polymorphism <i>GFI1-36N</i> Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acu... by Jan Vorwerk, Longlong Liu, Theresa Helene Stadler, Daria Frank, Helal Mohammed Mohammed Ahmed, Pradeep Kumar Patnana, Maxim Kebenko, Eva Dazert, Bertram Opalka, Nikolas von Bubnoff, Cyrus Khandanpour

“…The presence of the <i>GFI1-36N</i> gene variant is associated with a reduced DNA repair capacity favoring myeloid leukemogenesis and leads to an inferior prognosis of acute myeloid leukemia (AML) patients. However, the underlying reasons for the reduced DNA repair capacity in <i>GFI1-36N</i> leukemic cells are largely unknown. …”
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Impact of viral load on sample pooling for reverse-transcription polymerase chain reaction detection-based diagnosis of coronavirus disease 2019 in Nigeria by Timan T. Eliya, Elvis E. Isere, Bassey Emmana, Chukwuebuka Ugwu, Jonathan Kushim, Precious Ishaku, Aisha E. Ibrahim, John S. Bimba

“…Methods: A total of 1222 nasopharyngeal samples from symptomatic COVID-19 patients in Nasarawa State, Nigeria, collected between March 2021 and August 2022, were retrieved from the laboratory biorepository and analysed from November 2022 to February 2023. …”
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Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxyg... by Xinghui Wen, Xiaojuan Chen, Mei Li, Jinnian Zhou, Shouli Dao, Shixiang Li, Hui Cheng, Shuyun Zhao, Guanyou Huang

“…This experiment may provide a new direction and idea for the future treatment ofRPL patients.…”
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Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal... by Nanquan Rao, Xiaotong Wang, Jing Xie, Jingzhi Li, Yue Zhai, Xiaoxia Li, Tengjiaozi Fang, Yuanyuan Wang, Yuming Zhao, Lihong Ge

“…Stem cells from human exfoliated deciduous teeth (SHED) are MSCs that are derived from dental pulps in exfoliated deciduous teeth from young patients and therefore have a high proliferation rate and an easy access. …”
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Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial by Haiyan Shan, Mingyuan Xu, Jie Ni, Ling Zhou, Mengchun Xue, Jun Xue, Xiaohuan Yuan, Luyang Tao, Mingyang Zhang, Hong Zhang

“…Conclusions: This study confirms the therapeutic efficacy of H2S in facilitating the recovery of injured endometrium and revealed its potential therapeutic mechanism, offering a promising therapeutic avenue for patients with severe endometrial injury.…”
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Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis by Mengqi Liu, Mengqi Liu, Jie Tang, Jie Tang, Gaoyang Xu, Gaoyang Xu, Xu Chen, Xu Chen, Kun Fang, Fan He, Fan He, Yi Zheng, Yi Zheng

“…Previous studies have indicated that adolescents with MDD exhibit immune activation.ObjectiveThis study aimed to compare cytokine levels in adolescents with MDD to healthy controls and assess their diagnostic value.MethodsThis cross-sectional study included 58 adolescent patients with depression from Beijing Anding Hospital (outpatients and inpatients) and 40 healthy adolescents recruited from the community. …”
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The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angioten... by Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan

“…Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population. …”
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Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…Furthermore, our findings demonstrated the positive effects of physical activities on mitigating the cognitive burden of schistosomiasis, offering new hope for patients afflicted by this debilitating disease.…”
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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

“…Secondary outcomes include rates and type of disease progression, treatments received (for PCa and benign prostatic enlargement), overall and PCa-specific mortality, an understanding of patients/professionals views of this approach and health-related quality of life. …”
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Is Bigger Better? Living Donor Kidney Volume as Measured by the Donor CT Angiogram in Predicting Donor and Recipient eGFR after Living Donor Kidney Transplantation by Chaudhry Adeel Ebad, David Brennan, Julio Chevarria, Mohammad Bin Hussein, Donal Sexton, Douglas Mulholland, Ciaran Doyle, Patrick O’Kelly, Yvonne Williams, Ruth Dunne, Conall O’Seaghdha, Dilly Little, Martina Morrin, Peter J. Conlon

“…The recipients of living donor kidneys were 64% male and had a mean age of 43.5 years (SD ± 13.3). Six percent of patients experienced an episode of cellular rejection and were maintained on dialysis for a mean of 18 months (13–32) prior to transplant. …”
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Exploring the experiences of healthcare professionals in South Africa and Uganda around communicating with children about life-threatening conditions: a workshop-based qualitative... by Sue Ziebland, Julia Ambler, Julia Downing, Alan Stein, Elizabeth Namukwaya, Elizabeth Nabirye, Louise Walker, Elizabeth Rapa, Jeffrey R Hanna, Louise J Dalton, Teresa Pollard, Stephanie Santos-Paulo, Yasmin Gogay, David Kavuma, Ruth Mary Kemigisha, Juliet Namyeso, Tracey Brand, Beverley G Neethling

“…Objectives This study aimed to explore how published communication frameworks could be amended to ensure applicability and cultural appropriateness for professionals to support family-centred conversations by investigating’ healthcare professionals’ (1) experiences of providing support to families when a caregiver or a dependent child (&lt;18 years old) has a life-threatening condition, (2) perceived challenges for caregivers and healthcare professionals in communicating with children about illness, (3) perceptions of how clinicians could be equipped to facilitate conversations between caregivers and children about an adult or the child’s own life-threatening condition and (4) suggestions for amendments to previously published guidelines to ensure cultural relevance in South Africa and Uganda.Design A qualitative study involving two 2-day workshops with embedded focus group discussions, break out rooms and consensus discussions.Setting Health and social care and third sector organisations in South Africa and Uganda.Participants Thirty-two professionals providing care to families affected by life-threatening conditions in South Africa or Uganda who were aged 18 years or older and able to converse in English.Results Participants identified obstacles to having conversations with caregivers about children and to telling children about serious illness during consultations. These included patients’ beliefs about illness, medicine and death, language barriers between families and the healthcare team, and emotional and practical challenges for professionals in having these conversations. …”
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A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease by Yuyang Wang, Tongtong Liu, Fang Ma, Xiaoguang Lu, Huimin Mao, Weie Zhou, Liping Yang, Ping Li, Yongli Zhan

“…Tripterygium wilfordii Hook F (TwHF) is a widely employed herbal medicine in decreasing albuminuria among diabetic patients. However, a holistic network pharmacology strategy to investigate the active components and therapeutic mechanism underlying DKD is still unavailable. …”
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Are there Risks from Nanocomposite Restoration Grinding for Dentists? by Daniela Pelclova, Pavel Bradna, Lucie Lischkova, Vladimir Zdimal, Ludmila Maskova, Pavlina Klusackova, Viktoriia Kolesnikova, Jakub Ondracek, Jaroslav Schwarz, Miroslav Pohanka, Tomas Navratil, Stepanka Vlckova, Zdenka Fenclova, Jana Duskova, Andrea Rossnerova, Adela Roubickova

“…However, further studies are needed to evaluate oxidative stress in long-term exposure of both stomatologists and patients and diverse populations with varying health statuses.…”
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Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose by Shiqi Zhang, Juan Xu, Di Cui, Shujuan Jiang, Xin Xu, Yi Zhang, Dongchun Zhu, Li Xia, Benito Yard, Yonggui Wu, Qiu Zhang

“…We have previously reported that the CNDP1 (CTG)5 allele affords protection against diabetic nephropathy (DN) in patients with Type 2 diabetes (T2DM) of Caucasian origin. …”
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Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder by Yilu Zhao, Zhao Fu, Eric J. Barnett, Ning Wang, Kangfuxi Zhang, Xuping Gao, Xiangyu Zheng, Junbin Tian, Hui Zhang, XueTong Ding, Shaoxian Li, Shuyu Li, Qingjiu Cao, Suhua Chang, Yufeng Wang, Stephen V. Faraone, Li Yang

“…Based on genotype data of medication-naïve patients with ADHD who received pharmacological treatments for 12 weeks, the current study performed GWAS using the percentage changes in ADHD-RS score as phenotype. …”
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The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection by Rozeta Sokou, Alexia Eleftheria Palioura, Aikaterini Konstantinidi, Alexandra Lianou, Maria Lampridou, Martha Theodoraki, Daniele Piovani, Stefanos Bonovas, Konstantina A. Tsante, Petros Ioannou, Nicoletta Iacovidou, Andreas G. Tsantes

“…The results of this study highlight the need for monitoring of hemostatic status of this vulnerable group of patients and indicate that ROTEM analysis may have a role in the early detection of the hemostatic derangements associated with SCI in neonates, in order to ensure timely diagnosis and targeted therapeutic intervention.…”
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Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxici... by Hazal Aslan Rejeski, Hazal Aslan Rejeski, Anne Hartz, Anne Hartz, Elias Rackl, Elias Rackl, Lin Li, Lin Li, Christoph Schwepcke, Christoph Schwepcke, Kai Rejeski, Kai Rejeski, Christoph Schmid, Christoph Schmid, Andreas Rank, Andreas Rank, Jörg Schmohl, Doris Kraemer, Peter Bojko, Helga Maria Schmetzer, Helga Maria Schmetzer

“…Overall, DCleu-based immunotherapy represents a promising treatment strategy for AML patients.…”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…These data suggest that L1CAM-CAR T cell therapy combined with pharmacological MYCN inhibition may benefit patients with MYCN-amplified neuroblastoma.…”
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Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning by Fei Wang, Yuanxin Lin, Lian Qin, Xiangtai Zeng, Hancheng Jiang, Yanlan Liang, Shifeng Wen, Xiangzhi Li, Shiping Huang, Chunxiang Li, Xiaoyu Luo, Xiaobo Yang

“…A novel integrative analysis identified a cluster of TC patients characterized by increased PFHxA, PFDoA, PFHpA and decreased PFOA, PFHxS levels, and altered metabolite patterns highlighted by the upregulation of free fatty acids. …”
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