Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells by Jan Trieschmann, Moritz Haustein, Annette Köster, Jürgen Hescheler, Konrad Brockmeier, Gerardus Bennink, Tobias Hannes

“…Myocardial tissue slices were prepared from biopsies obtained from patients undergoing surgery for hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (TOF). …”
Get full text

Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study by Wang YP, Wei HX, Hu YY, Zhang C, Niu YM

“…Yu-Pei Wang,1,* Hui-Xia Wei,2,* Yuan-Yuan Hu,3 Chao Zhang,4 Yu-Ming Niu3– 5 1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 3Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China; 4Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 5Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu-Ming Niu, Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China, Tel +86 13581370999, Email niuyuming@yeah.net Chao Zhang, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China, Email zhangchao0803@126.comObjective: Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. …”
Get full text

Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy by Martin Stattin, Stefan Hagen, Daniel Ahmed, Eva Smretschnig, Florian Frommlet, Katharina Krepler, Siamak Ansari-Shahrezaei

“…Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350 μm (SW-350) and 1200 μm (SW-1200) diameter circle centered on the fovea and normalized with the level of SW-FAF GV in a 30° image of 20 eyes in 11 patients initially treated for unilateral acute symptomatic CSCR were collected and retrospectively analyzed after 7 years. …”
Get full text

Glu4: An open-source package for real-time forecasting and alerting post-bariatric hypoglycemia based on continuous glucose monitoring by Luca Cossu, Francesco Prendin, Giacomo Cappon, David Herzig, Lia Bally, Andrea Facchinetti

“…A pilot study involving three PBH patients collected real-time glucose data to validate the system’s predictive performance. …”
Get full text

Rapid detection of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae in positive blood cultures via MALDI-TOF MS and tree-based machine learning... by Xiaobo Xu, Zhaofeng Wang, Erjie Lu, Tao Lin, Hengchao Du, Zhongfei Li, Jiahong Ma

“…Early identification of infectious agents and determination of drug-resistant phenotypes can help patients with BSI receive timely, effective, and targeted treatment and improve their survival. …”
Get full text

Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone by Souhila Ait-Tigrine, Roger Hullin, Elsa Hoti, Matthias Kirsch, Piergiorgio Tozzi

“…An equation to predict the risk, including the 11 parameters (GREF-11), was created using logistic regression models and validated based on our experience involving 116 patients. In our series, 29 recipients (25%) required extracorporeal membrane oxygenation support within 24 hours post-HTx. …”
Get full text

Weaving oral health provider perspectives to guide future dental therapy advocacy and implementation efforts by Amanda J. Llaneza, Amanda J. Llaneza, Kara A. Stone, Julie Seward

“…Descriptive statistics were utilized to report the position type of attendees, years of experience in the role, incorporation of clinical courses for DT scope of practice, and clinic management and administration for their patients. Surveys included two open-ended questions inquiring about personal objectives and comments and suggestions regarding the conference overall. …”
Get full text

Classification and Statistical Trend Analysis in Detecting Glaucomatous Visual Field Progression by Cristiana Valente, Elisa D’Alessandro, Michele Iester

“…This is a retrospective and longitudinal study. Twenty Caucasian patients (mean age 73.8 ± 13.43 years) with open-angle glaucoma were recruited in the study. …”
Get full text

Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…Run jia Liu,1 Miao Li,1 Qian Zhu,1 Hui ying Liu,1 Xing xiu Zhang,1 Xiang yuan Han,1 Meng jun Yu,1 Jian wen Zhou,2 Cui yan Han1 1School of Pharmacy, Qiqihar Medical University, Qiqihar, People’s Republic of China; 2Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, People’s Republic of ChinaCorrespondence: Cui yan Han, School of Pharmacy, Qiqihar Medical University, Qiqihar, People’s Republic of China, Tel/Fax +86-24-2663822, Email hcymuphar@qmu.edu.cnPurpose: Acne is a serious disfiguring follicular sebaceous gland disorder that negatively affects patients’ quality of life and self-image. Chloramphenicol (CAM) is effective against Propionibacterium acnes and Staphylococcus aureus which cause acne, often used as a hospital preparation for acne treatment. …”
Get full text

Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis by Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin

“…Analysis of CTSS expression in tumors and tissues, along with the construction of a prognostic model, revealed that CTSS expression was higher in both primary CM and metastatic CM compared to normal skin tissue. However, patients with higher CTSS expression had a higher prognosis. …”
Get full text

Characterisation of cardiovascular disease (CVD) incidence and machine learning risk prediction in middle-aged and elderly populations: data from the China health and retirement lo... by Qing Huang, Zihao Jiang, Bo Shi, Jiaxu Meng, Li Shu, Fuyong Hu, Jing Mi

“…Although the LGB model demonstrates good overall performance, its low F1 score and recall rate reveal limitations in identifying high-risk cardiovascular disease patients.…”
Get full text

Prevalence and Detection of qac Genes from Disinfectant-Resistant Staphylococcus aureus Isolated from Salon Tools in Ishaka Town, Bushenyi District of Uganda by Solange Gahongayire, Adamu Almustapha Aliero, Charles Drago Kato, Alice Namatovu

“…Bacterial infections are on a rise with causal-resistant strains increasing the economic burden to both patients and healthcare providers. Salons are recently reported as one of the sources for transmission of such resistant bacterial strains. …”
Get full text

Complex high-risk indicated PCI (CHIP-PCI): is it safe to let fellows-in-training perform it as primary operators? by Tim Kinnaird, Zia Ul-Haq, Holly Morgan, Anirban Choudhury, Majd B Protty, Alexander Chase, David Hildick-Smith, Shantu Bundhoo, Saad Hasan, Diluka Premawardhana, Ahmed Hailan, Mohammed Shugaa Addin, Hussain Hussain

“…Sensitivity analyses restricted to patients with higher CHIP Scores (4+ and 5+) showed comparable IH-MACCE.Conclusions Training FIT as primary operators in CHIP-PCI appears to be feasible and safe and can be delivered within the standard training programme. …”
Get full text

Role of Toll-Like Receptor 2 in Regulation of T-Helper Immune Response in Chronic Obstructive Pulmonary Disease by Karolina A. Sidletskaya, Tatyana I. Vitkina, Yulia K. Denisenko, Elena E. Mineeva

“…Spearman’s correlation test was performed. Results. Patients with COPD GOLD II and III with Th1 and Th17 cytokine profiles exhibited an increase in the percentage of CD4+CD282+ cells compared to the control group. …”
Get full text

Seroprevalence of anti-ToxoplasmaIgG among the human population in Indonesia: a systematic review and meta-analysis by Taufik Mulya Perdana, Alfin Harjuno Dwiputro, Stefanie Kusuma, Artha Maressa Theodora Simanjuntak, Frengki Prabowo Saputro Wijayanto

“…Abstract Background Toxoplasma gondii is a ubiquitous parasite that can cause significant complications when it infects pregnant women and immunocompromised patients. These complications include miscarriage, fetal abnormalities, and fatal cerebral toxoplasmosis. …”
Get full text

Digital Health Program to Support Family Caregivers of Children Undergoing Growth Hormone Therapy: Qualitative Feasibility Study by Alba Jiménez-Díaz, Maitena Pierantonelli, Patricia Morte Coscolín, Amaia Salinas-Uhalte, Silvia Quer-Palomas, Octavio Rivera-Romero, Rocío Herrero, Luis Fernández-Luque, Rosa Baños, Ricardo C Berrios, Antonio de Arriba

“…ConclusionsThe ACDP is a promising and well-accepted tool that enhances the experience of patients and caregivers. It improves the management of growth hormone deficiency and promotes the overall well-being of family caregivers. …”
Get full text

Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population by Hamid Farhane, Majida Motrane, Karchali Soufaine, Fatima-Ezzahra Anaibar, Aïcha Motrane, Said Nassor Abeid, Abderraouf Hilali, Nourdin Harich

“…Results Our results showed that the Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms are significantly associated with MetS, the patients are characterized by higher frequencies of genotype II (OR = 6.96, 95% CI [4.12–11.75], p < 0.0001) and *Ins allele for Alu-PV92, and DD genotype (OR = 3.32, 95% CI [1.57–7.00], p = 0.001) and *Del allele for Alu-APOA1 compared to controls. …”
Get full text

miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis by Han Li, Junyan Duan, Tongtong Zhang, Yingjie Fu, Yue Xu, Hongjun Miao, Xuhua Ge

“…In this study, the expression level of miR-16-5p was found to be significantly upregulated about 20-fold in S-AKI patients, and it also increased by 1.9 times in the renal tissue of S-AKI mice. …”
Get full text

Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…The safety analysis showed that Grades 3 and 4 adverse reactions occurred in 25 (29%) and 31 (36%) patients in the inosine and non‐inosine groups, respectively, and tended to decrease in the inosine group compared with the non‐inosine group. …”
Get full text

Characteristics of nursing homes and early preventive measures associated with risk of infection from COVID-19 in Lazio region, Italy: a retrospective case–control study by Leonardo Palombi, Alessio Abbondanzieri, Stefano Orlando, Tuba Mazhari, Gennaro Cerone, Fausto Ciccacci, Giuseppe Liotta, Sandro Mancinelli, Maria Cristina Marazzi

“…Other characteristics and measures were not associated with an outbreak.Conclusion There was evidence of a higher risk of COVID-19 in larger facilities and when new patients were admitted during the pandemic. All other structural–organisational characteristics and preventative measures were not associated with an outbreak. …”
Get full text