Preoperative anxiety and its impact on surgical outcomes: A systematic review and meta-analysis by Mohamed A. Shebl, Eman Toraih, Menna Shebl, Ahmed Mosaad Tolba, Parisa Ahmed, Harshdeep Singh Banga, Mohab Orz, Mahmoud Tammam, Keroles Saadalla, Mohamed Elsayed, Mennatallah Kamal, Mohamed Abdulla, Ahmed Ibrahim Eldessouky, Yousef Tarek Moustafa, Omar Ahmed Mohamed, Hani Aiash

“… Abstract Background: Preoperative anxiety is a common phenomenon affecting 60–80% of surgical patients, with potential implications for surgical outcomes. …”
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Unveiling the psychosocial and academic implications of living with sickle cell disease among undergraduates in a private university in Nigeria by Olumide T. Adeleke, Olufemi Folaranmi, Yetunde Olasinde, Larry Ayuba, Oludamola V. Adeleke, Modupe M. Ojo-Rufai, Efeturi Agelebe, Oyelola E. Adeoye, Aderemi T. Olabode, Dolapo E. Ajala, Titilola S. Akingbola

“…Conversely, some SCD patients enjoy some social support from colleagues and family members which gives hope and succor to them during difficult times.ConclusionThis study reveals that undergraduates with SCD face various academic and psychosocial challenges that affect their overall performance. …”
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Global variation in the assessment of psychological trauma in pregnancy by Kathryn Wall, Francesca Penner, Lindsey Wallace Goldman, Jin Young Shin, Eloise Novak, Amanda Lowell, Michèle Day, Lea Papa, Drew Wright, Soudabeh Givrad, Helena J. V. Rutherford

“…Newly developed measures can be used for screening and treatment of patients using trauma-informed obstetric care.…”
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Oligogenic effect is associated with the clinical heterogeneity of autosomal dominant deafness-15 by Jianyan Pan, Hua Teng, Fang Liu, Siyi Chen, Yaning Liu, Yanling Teng, Desheng Liang, Zhuo Li, Lingqian Wu

“…In this study, A four-generation Chinese family with 11 patients manifesting late-onset progressive non-syndromic hearing loss was recruited. …”
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Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus by Sergey A. Klotchenko, Ekaterina A. Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia A. Pulkina, Aram A. Shaldzhyan, Dmitry S. Balabashin, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov

“…RSV also poses a serious threat to the elderly and immunocompromised patients. Developing a therapy based on recombinant human antibodies to block the RSV fusion (F) glycoprotein is urgent to reduce the incidence of RSV infections and prevent associated complications. …”
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Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

“…Conclusion These findings showed that individuals with CH due to TET2 mutations may have a higher risk of developing PAH, suggesting that the CH patients may be tested for TET2 gene mutations.…”
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ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy by Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

“…We compare human epiretinal membranes and vitreous samples from nondiabetic subjects and patients with proliferative diabetic retinopathy (PDR) and extend in vitro analyses with the use of various immunodetection and spectrofluorimetric methods on rat retina and human retinal glial and endothelial cell cultures. …”
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Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study by Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Fabio Angeli, Carlo Maria Barbagallo, Bruno Berardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Lanfranco D’Elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Egidio Imbalzano, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

“…TG/HDL-C ratio showed a positive association with increasing of SUA/GFR ratio, even in non-diabetic patients. Multivariate analysis showed that the TG/HDL-C ratio increases the mortality risk even after adjustment for potential confounding factors. …”
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Hepatic Abnormal Secretion of Apolipoprotein C3 Promotes Inflammation in Aortic Dissection by Xinghui Zhuang, Mohammad Zarif, Yue Shen, Zhaofeng Zhang, Jian He, Linfeng Xie, Qingsong Wu, Xinfan Lin, Keyuan Chen, Yue Tian, Yong Lin, Yuling Zhang, Ziwen Cai, Zhihuang Qiu, Liangwan Chen

“…Previous studies have shown that apo C3 is abundant in the plasma exosomes of patients with aortic dissection (AD), but its specific role in AD remains unclear. …”
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Measurement of Circulating 1,25-Dihydroxyvitamin D: Comparison of an Automated Method with a Liquid Chromatography Tandem Mass Spectrometry Method by Armin Zittermann, Jana B. Ernst, Tobias Becker, Jens Dreier, Cornelius Knabbe, Jan F. Gummert, Joachim Kuhn

“…Using the method-specific cut-offs for deficient 1,25(OH)2D levels (<20 pg/mL for the automated assay and <17 pg/mL for the LC-MS/MS method), the percentage of patients classified as 1,25(OH)2D deficient was 28.7% and 27.1%, respectively. …”
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Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongsi... by Yin Wang, Jiarui Zou, Qinghua Cao, Guihong Dai, Panhong Fan, Xue Gong, Jinyan Jiang, Yanqing Kong, Chao Liu, Chunhui Liu, Chenjia Lu, Meiren Li, Zhiqiang Lang, Yang Lin, Yan Peng, Haiyan Shi, Yuhuan Wang, Jiu Wang, Bichen Xie, Bing Yang, Guohua Yu, Cuiping Zhang, Hengming Zhang, Luting Zhou, Zilan Zhang, Zhenli Zhu, Junmei Hao

“…PurposeRecommendations from the National Health Commission of China (NHCC) and the International Ki67 Working Group (IKWG) were issued to guide immunohistochemistry (IHC)-based Ki67 scoring for breast cancer patients in daily clinical practice. They were evaluated in this multi-institutional study alongside the results from the Quantitative Dot Blot (QDB) method.MethodsThree alternative adjacent sections from 40 primary ER+ breast cancer resection blocks were randomly assigned a number from 1 to 120 for Ki67 staining and reviewed by 21 pathologists, while the other three alternative sections were sent for QDB analysis of Ki67 protein levels. …”
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Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm by Marcos Vinícius Melo de Oliveira, MD, PhD, Alexandre Malta Brandão, MD, PhD, Gina Camillo Rocha Silvestre, BS, Alexandre Queiroz Silva, BS, Michele Alberto Marques, BS, Marcia Martins Reis, PhD, Maria de Lourdes Higuchi, MD, PhD, Erasmo Simão da Silva, MD, PhD

“…Methods: This study included 180 patients with AAA and 18 with PAA. Medical history and imaging data were collected. …”
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Subjective and objective stress during body exposure: a comparison of adolescents with anorexia nervosa versus high body dissatisfaction by Valeska Stonawski, Louisa Kuper, Nicolas Rohleder, Gunther H. Moll, Hannah Fischer, Anne-Christine Plank, Tanja Legenbauer, Oliver Kratz, Stefanie Horndasch

“…Within a controlled design comparing adolescents with AN (n = 34) vs. adolescent patients with high BD (n = 17) but without a diagnosed ED, subjective (stress ratings; 11-point Likert scale) and objective (salivary cortisol and alpha-amylase [sAA]) stress measures were assessed at four time points at each exposure session (start, +10 min, +30 min/end, +60 min/recovery). …”
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Development and validation of predictive models of early immune effector cell–associated hematotoxicity by Emily C. Liang, Jennifer J. Huang, Andrew J. Portuguese, Valentín Ortiz-Maldonado, Aya Albittar, Natalie Wuliji, Ryan Basom, Yein Jeon, Qian Wu, Aiko Torkelson, Delaney Kirchmeier, Abigail Chutnik, Barbara Pender, Mohamed Sorror, Joshua A. Hill, Noam E. Kopmar, Rahul Banerjee, Andrew J. Cowan, Damian Green, Ajay K. Gopal, Christina Poh, Mazyar Shadman, Alexandre V. Hirayama, Brian G. Till, Erik L. Kimble, Lorenzo Iovino, Aude G. Chapuis, Folashade Otegbeye, Ryan D. Cassaday, Filippo Milano, Cameron J. Turtle, David G. Maloney, Jordan Gauthier

“…Therefore, we performed comprehensive univariate analyses to identify factors associated with severe (grade 3-4) early ICAHT (eICAHT) in 691 patients who received commercial or investigational CAR T-cell therapy for hematologic malignancies. …”
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Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders by Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang

“…Inflammatory damage in patients with rheumatic diseases promotes the release of cfDNA, while potential abnormalities in cfDNA metabolism further increase its levels. …”
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Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota by Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu

“…We enrolled 72 individuals from 9 LS families across six provinces in China and employed 16S rRNA gene amplicon sequencing to analyze the fecal microbiota components among LS-related CRC patients (AS group), their spouses (BS group), mutation carriers without CRC (CS group), and non-mutation carriers (DS group) using alpha and beta diversity indices. …”
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Adrenal (Pro)renin Receptor Expression and Serum Soluble (Pro)renin Receptor Concentration in Primary Aldosteronism by Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, Yoichiro Kato, Yoji Nagashima, Noriyuki Shibata, Atsuhiro Ichihara

“…This study investigated the significance of (P)RR and serum s(P)RR concentrations in patients with APA. We evaluated associations between (P)RR expression and expression of CYP11B2, an aldosterone synthase, and aldosterone production by the adrenal glands and assessed the relationships between serum s(P)RR concentration and background factors. …”
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Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis by Juan R. Ulloque-Badaracco, Esteban A. Alarcon-Braga, Enrique A. Hernandez-Bustamante, Enrique A. Hernandez-Bustamante, Beatrix M. Von-Koeller-Jones, Miguel Huayta-Cortez, Esduardo Saavedra-Custodio, Percy Herrera-Añazco, Vicente A. Benites-Zapata

“…Publication bias was assessed using funnel plots and the Egger test.ResultsTwenty studies were included with a combined study population of 7,791 patients. There were no significant differences between children/adolescents with and without obesity with respect to serum vitamin B12 levels (SMD: −0.24; 95% CI: −0.53 to 0.06; p &gt; 0.05, I2 = 74.93%) and folate levels (SMD: −0.12; 95% CI: −0.29 to 0.06; p &gt; 0.05, I2 = 19.6%). …”
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Evaluation of a strategy for tumor-initiating stem cell eradication in primary human glioblastoma cultures as a model by E. V. Dolgova, A. S. Proskurina, E. A. Potter, T. V. Tyrinova, O. S. Taranov, Ya. R. Efremov, K. E. Orishchenko, S. V. Mishinov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…Primary cultures of human glioblastoma were obtained from the surgical material of patients K. (female, 61 years, Ds: relapse of glioblastoma) and Zh. …”
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Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review by Suélia de Siqueira Rodrigues Fleury Rosa, Mário Fabrício Fleury Rosa, Marcos Augusto Moutinho Fonseca, Glécia Virgolino da Silva Luz, Carlos Federico Domínguez Avila, Aldira Guimarães Duarte Domínguez, Aldene Guimarães Duarte Dantas, Von Braun Richter

“…Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. …”
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