Assessment of Antimicrobial Use for Companion Animals in South Korea: Developing Defined Daily Doses and Investigating Veterinarians’ Perception of AMR by Sun-Min Kim, Heyong-Seok Kim, Jong-Won Kim, Kyung-Duk Min

“…We collected data on 684,153 antimicrobial prescription visits for canine and feline patients from 2019 to 2022 at 100 veterinary facilities in South Korea, using electronic medical records. …”
Get full text

Efficacy and Safety of Different Acupuncture Treatments for Cancer-Related Pain: A Systematic Review and Network Meta-Analysis by Tianle Xie MD, Can Liu MD, Yudi Wu MD, Xiuxiu Li MD, Qianyun Yang PhD, Jing Tan PhD

“…Conclusion: Acupuncture + Traditional Chinese medicine is the best intervention for different acupuncture methods in the treatment of cancer pain, and Moxibustion + Usual Medicine is the best intervention to improve the quality of life of patients.…”
Get full text

A Novel Tool for High-Throughput Screening of Granulocyte-Specific Antibodies Using the Automated Flow Cytometric Granulocyte Immunofluorescence Test (Flow-GIFT) by Xuan Duc Nguyen, Thomas Dengler, Monika Schulz-Linkholt, Harald Klüter

“…The flow cytometric granulocyte immunofluorescence test (Flow-GIFT) has been introduced for routine use when investigating patients and healthy blood donors. Here we describe a novel tool in the automation of the Flow-GIFT that enables a rapid screening of blood donations. …”
Get full text

Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…In the GEO cohorts, this risk model demonstrated excellent predictive abilities for prognosis. Further, patients with high-risk scores had a lower likelihood of benefiting from immunotherapy. …”
Get full text

Elevated Plasma Level of 8-Hydroxy-2′-deoxyguanosine Is Associated with Primary Open-Angle Glaucoma by Altaf A. Kondkar, Taif A. Azad, Tahira Sultan, Essam A. Osman, Faisal A. Almobarak, Saleh A. Al-Obeidan

“…To determine the association between plasma 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, a marker for oxidative DNA damage, and patients with primary open-angle glaucoma (POAG) or its clinical phenotypes. …”
Get full text

The Effectiveness of Acupuncture on Myofascial Trigger Points Versus Traditional Chinese Medicine Acupoints for Treating Plantar Fasciitis With Low Back Pain: A Study Protocol for... by Huang Z, Liang X, Luo Y, Fang Z, Xu M, Xu Y, Cheng S, Li L

“…This trial aims to compare the effectiveness of acupuncture at trigger points versus Traditional Chinese Medicine (TCM) acupoints in the treatment of participants with plantar fasciitis and low back pain.Methods: The trial will be a single-centre, parallel two-group, randomised controlled trial with 62 participants allocated in a 1:1 ratio to either the trigger point group or the TCM acupoint group. Patients with plantar fasciitis and low back pain will be enrolled in this trial. …”
Get full text

Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization by Lu Ding, Bo Chen, Zhou Zhou, Zhaojun Mei, Kan Cao, Xinyu Lu, Wei Chen

“…Abstract Previous studies have indicated a significantly higher prevalence of breast cancer (BC) among female patients with meningioma compared to the general female population. …”
Get full text

FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers by Yongchang Tang, Hong Wang, Jiankun Zhang, Chunhui Yang, Fei Xu, Yan Song, Tianen Li, Qiangbo Zhang

“…Furthermore, we validated these findings in our own cohort of hepatocellular carcinoma (HCC) patients. We found that FLT3 alteration and expression were both significantly upregulated in AML and were associated with poor prognosis, which is opposite to its role in solid cancers. …”
Get full text

The role of statins in dementia or Alzheimer’s disease incidence: a systematic review and meta-analysis of cohort studies by Ye Du, Zhangjie Yu, Chengyi Li, Yanxing Zhang, Buyun Xu, Buyun Xu

“…We applied the DerSimonian–Laird random effects method to pool hazard ratio (HR) with 95% confidence intervals (CI).ResultsWe included forty-two studies comprising 6,325,740 patients. Thirty-five cohort studies involving 6,306,043 participants were pooled and indicated that statin use was associated with a reduced risk of dementia (HR: 0.79, 95% CI: 0.71–0.88). …”
Get full text

Variations in the composition and frequency of celiac disease epitopes among synthetic wheat lines by Rahman Ebrahimzadegan, Ghader Mirzaghaderi

“…Despite the significant importance in breadmaking properties, wheat gluten contains some immunogenic peptides capable of triggering a T cell reaction in celiac disease (CD) patients, leading to inflammation in the small intestine. …”
Get full text

Predictive Factors for Access-Site Pain Chronicity after Percutaneous Coronary Intervention via Radial Artery Access by Liuda Brogiene, Giedre Baksyte, Agne Klimaite, Martynas Paliokas, Andrius Macas

“…Methods. Data of selected patients (n = 161) who underwent elective PCI were collected prospectively and analysed in 2020. …”
Get full text

Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks by Guihong Chen, Wen Zhang, Chenglin Wang, Muhu Chen, Yingchun Hu, Zheng Wang

“…Blood samples from sepsis patients in the Affiliated Hospital of Southwest Medical University were collected. …”
Get full text

Hubungan Status Gravida dan Usia Ibu terhadap Kejadian Preeklampsia di RSUP Dr. M. Djamil Padang Tahun 2012-2013 by Oktaria Denantika, Joserizal Serudji, Gusti Revilla

“…Djamil Padang on 2012 – 2013.The research was did in January 2014 to February 2014 at Medical Records department using cross sectional study comparative’s design toward 81 preeclamptic patients and 81 pregnant women who didn’t preeklampsia, which gave birth in RSUP Dr. …”
Get full text

Plasmodium Falciparum Genetic Diversity and Multiplicity of Infection Among Asymptomatic and Symptomatic Malaria-Infected Individuals in Uganda. by Mwesigwa, Alex, Ocan, Moses, Cummings, Bryan, Musinguzi, Benson, Kiyaga, Shahid, Kiwuwa, Steven M., Okoboi, Stephen, Castelnuovo, Barbara, Bikaitwoha, Everd Maniple, Kalyango, Joan N., Karamagi, Charles, Nankabirwa, Joaniter I., Nsobya, Samuel L., Byakika‐Kibwika, Pauline

“…Methods This cross-sectional study analyzed 225 P. falciparum isolates from both asymptomatic and symptomatic malaria patients, ranging in age from 6 months to≥18 years. …”
Get full text

An Update on African Trypanocide Pharmaceutics and Resistance. by Keneth Iceland, Kasozi, MacLeod, Ewan Thomas, Ntulume, Ibrahim, Welburn, Susan Christina

“…Nifurtimox alone is regarded as a poor trypanocide, however, it is effective in melarsoprol-resistant gHAT patients. Resistance is associated with loss of a single copy of the genes encoding for nitroreductase enzymes. …”
Get full text

Surgical interventions for spontaneous supratentorial intracerebral haemorrhage: a systematic review and network meta-analysisResearch in context by Jiayidaer Huan, Minghong Yao, Yu Ma, Fan Mei, Yanmei Liu, Lu Ma, Xiaochao Luo, Jiali Liu, Jianguo Xu, Chao You, Hunong Xiang, Kang Zou, Xiao Liang, Xin Hu, Ling Li, Xin Sun

“…Findings: Of the 8573 total records identified by our searches, 31 studies (6448 patients) were eligible for the systematic review and network analysis. …”
Get full text

Active case detection and treatment of malaria in pregnancy using LAMP technology (LAMPREG): a pragmatic randomised diagnostic outcomes trial—study protocol by Mekonnen Teferi, Claire Kamaliddin, Hiwot Tilahun, Rediet Fikru Gebresenbet, Zelalem Mekonnen Bekele, Banchamlak Tegegne, Delenasaw Yewhalaw, Abebe Genetu Bayih, Dylan R Pillai, Filmona Mekuria, Getaneh Alemu, Beka Raya, Omar Abdullah, Taye Teka, James Cheaveau, Ruth Legese, Hiwot Asmerom, Ermias Hundito, Ebrahim Nursefa, Samuel Ayele

“…In the standard of care arm, a venous blood sample will be collected for malaria diagnosis only in symptomatic patients. In contrast, in the intervention arm, mothers will be tested by a commercially available Conformité Européene (CE)-approved LAMP malaria test, microscopy and rapid diagnostic test for malaria regardless of their symptoms at each antenatal care visit. …”
Get full text

Prevalence and influencing factors of occupational burnout among healthcare workers in the Chinese mainland during the late 2022 Omicron COVID-19 outbreak: a multicenter cross-sect... by Shu Jing, Zhenwei Dai, Yijin Wu, Xin Liu, Ling Zhang, Xiaoyang Liu, Tianrui Ren, Jiaqi Fu, Xu Chen, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Zhili Han, Xiaoyou Su, Youlin Qiao

“…Working as nurses, in a department currently taking charge of the treatment of COVID-19 patients, perceived high risk of contracting COVID-19 due to work, perceived high work intensity, and a higher level of anxiety and depressive symptoms were risk factors of occupational burnout. …”
Get full text

A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy by Weie Zhou, Xuefeng Zhou, Yuan Zhang, Yuyang Wang, Wenjie Wu, Haojun Zhang, Tingting Zhao, Liang Peng, Hailing Zhao, Ping Li

“…As a CHM, Tangshen Formula (TSF) was used to treat DN patients in China. However, its bioactive compounds and holistic pharmacological mechanisms on DN are both unclear. …”
Get full text

Automatic cervical lymph nodes detection and segmentation in heterogeneous computed tomography images using deep transfer learning by Wenjun Liao, Xiangde Luo, Lu Li, Jinfeng Xu, Yuan He, Hui Huang, Shichuan Zhang

“…Abstract To develop a deep learning model using transfer learning for automatic detection and segmentation of neck lymph nodes (LNs) in computed tomography (CT) images, the study included 11,013 annotated LNs with a short-axis diameter ≥ 3 mm from 626 head and neck cancer patients across four hospitals. The nnUNet model was used as a baseline, pre-trained on a large-scale head and neck dataset, and then fine-tuned with 4,729 LNs from hospital A for detection and segmentation. …”
Get full text