Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Methods Using data from multiple researches, we comprehensively evaluated the characteristics and prognostic impact of PSI features in DLBCL, and developed a novel risk stratification model (PSI score) with a consistent cutoff value to stratify the risk of 3,229 DLBCL patients from different cohorts. Mechanisms underlying adverse prognosis in the high-risk DLBCLs were investigated through transcriptomic (n = 3,229), genomic (n = 576), and scRNA-seq (n = 20) analyses. …”
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Healthcare Practitioners’ perspectives on paediatric burns management at Korle Bu Teaching Hospital, Ghana by Alberta A. Rockson, Natalie Benjamin-Damons, Sonti Imogene Pilusa

“…In resource-limited settings like Ghana, the absence of adequate supplies and standardized protocols can exacerbate these challenges, necessitating the need for a comprehensive understanding of the perspectives of healthcare practitioners involved in their care.Study Objective.To explore healthcare practitioners’ perspectives on paediatric burns management at a tertiary hospital, Ghana, covering current practices, barriers, impacts on patients and families, and recommendations for improvement. …”
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Cell-Based Therapies for the Treatment of Shoulder and Elbow Tendinopathies: A Scoping Review by Berardo Di Matteo, Riccardo Ranieri, Angelo Manca, Simone Cappato, Maurilio Marcacci, Elizaveta Kon, Alessandro Castagna

“…Exclusion criteria were as follows: case reports or mini case series (<5 patients), articles not written in English, and reviews. …”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic (PK) profile and safety of HA121-28 tablet in healthy subjects.Patients and Methods: A single-dose, randomized, open-label, two-period, crossover-designed phase I clinical trial was conducted. …”
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Factors Influencing the Pregnancy Outcome of Intrauterine Insemination and Follow-Up Treatment by Xuan Huang, Qin Sun, Xu Tang, Meiling Li, Cheng Zhou, Xi Cheng, Bing Yao, Li Chen

“…Further analysis showed that when patients with IUI had the following conditions: AMH &gt; 4.5 ng/ml, EMT between 8 and 12 mm and letrozole + human menopausal gonadotropin stimulation with higher clinical pregnancy. …”
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Effectiveness of Intravitreal Ranibizumab in Nonvitrectomized and Vitrectomized Eyes with Diabetic Macular Edema: A Two-Year Retrospective Analysis by Ozgun Melike Gedar Totuk, Ayse Yagmur Kanra, Mohammed Nadim Bromand, Guler Kilic Tezanlayan, Sevil Ari Yaylalı, Irem Turkmen, Aylin Ardagil Akcakaya

“…The medical records of 28 eyes (11 vitrectomized and 17 nonvitrectomized) of 28 patients (mean age, 59.0 ± 9.6 years; male to female ratio 1 : 1) who were diagnosed with DME and had received IVR treatment were reviewed retrospectively. …”
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Congenital Bullous Syphilis: A Case Report from Italy and a Comprehensive Literature Review by Edoardo Cammarata, Elia Esposto, Nunzia Di Cristo, Chiara Airoldi, Elena Bernascone, Valentina Burzio, Paola Savoia

“…<i>Results</i>: Twenty-four cases of congenital syphilis with bullous lesions were identified, twenty with sufficient detail for analysis. Patients presented three distinct clinical patterns: confined palmoplantar lesions, acrally distributed lesions, and diffuse bullous-erosive involvement. …”
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Does interprofessional simulation increase self-efficacy: a comparative study by Peter Jaye, Gabriel Reedy, Alastair Ross, Colm Watters, Nicola J Morgan, Rhodri Handslip

“…Simulation education attempts to create an environment for healthcare professionals to learn, without potential safety risks for patients. Integrating simulation and interprofessional education can provide benefits to individual learners.Setting The intervention took place in a high-fidelity simulation facility located on the campus of a large urban hospital. …”
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Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants by null Turyadi, Billy Witanto, Korri E. El-Khobar, M. Luthfi Parewangi, M. Rezki Rasyak, Dhita P. Wibowo, Meta D. Thedja, Irawan Yusuf, Muh. Nasrum Massi, Ilhamjaya Patellongi, Din Syafruddin, David H. Muljono

“…Here, we determined the association of TNF-α (rs1800629) and IL-10 (rs1800896 and rs1800872) SNPs in the context of CHB natural history progression, particularly to HBeAg seroconversion, in Indonesian CHB patients. Methods. A total of 287 subjects were recruited and categorized into distinct CHB phases based on HBeAg, viral load, and ALT levels. …”
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A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder (WAD): Part 5 – Surgical and Injection-Based Interventions for Chronic WAD by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…While many treatments have been advocated for patients with WAD, scientific support regarding their effectiveness is often lacking. …”
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Construction and Validation of a Model for Predicting Fear of Childbirth: A Cross-Sectional Population Study via Machine Learning by Zhang ZL, Chen KJ, Chen H, Zhu MM, Gu JJ, Jiang LS, Zheng L, Zhou SG

“…General information and relevant medical data of the patients were collected for data aggregation. The data was randomly divided into a training set (n = 632) and a testing set (n = 269) in a 7:3 ratio. …”
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Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia mac... by Piyush Kumar, Sai Anand Kannakazhi Kantari, Ranendra Pratap Biswal, Prasanth Ghanta, Malleswara Dharanikota

“…Inhibition of α-glucosidase responsible for postprandial hyperglycemia among diabetes patients is a promising strategy for managing the disease. …”
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Association between nutritional inflammation index and diabetic foot ulcers: a population-based study by Zhou Lin, Wanli Zhuang, Lei Wang, Weifeng Lan

“…Therefore, for diabetic patients with low serum albumin, appropriate supplementation of albumin was crucial. …”
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Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma by Nicholas M. Pfahler, Jordan L. Barry, Indre E. Bielskus, Agni Kakouri, Michael C. Giovingo, Nicholas J. Volpe, Paul A. Knepper

“…Subanalyses were conducted in POAG patients examining the association between nailfold capillary outcomes and previous glaucoma surgery, successful IOP control, or disease severity. …”
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Composite cardiovascular risk factor control in US adults with diabetes and relation to social determinants of health: The All of Us research program by Frances Golden, Johnathan Tran, Nathan D. Wong

“…Background: Data are limited on composite cardiovascular risk factor control in patients with type 2 diabetes mellitus (T2DM). This study aims to identify disparities in cardiovascular risk factor control based on most recent recommendations and relationships to social determinants of health in a large-scale real-world cohort of US adults. …”
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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…These findings identify critical pathways and cell populations as potential therapeutic targets, offering new strategies to improve treatment outcomes in BC patients.…”
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Verification of the Reliability of an Automated Urine Test Strip Colorimetric Program Using Colorimetric Analysis: Survey Study by Keigo Inagaki, Daisuke Tsuriya, Takuya Hashimoto, Katsumasa Nakamura

“…In this study, urine samples from hospitalized or outpatient patients were randomly obtained, and the reliability of this program was verified by comparing the agreement rate between this program and an automatic urine analyzer (US-3500 [Eiken Chemical Co, Ltd] and LABOSPECT 006 [Hitachi High-Tech Co, Ltd]). …”
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Distance to Specialist Medical Care and Diagnosis of Obstructive Sleep Apnea in Rural Saskatchewan by Catherine M. Spagnuolo, Michael McIsaac, James Dosman, Chandima Karunanayake, Punam Pahwa, William Pickett

“…Obstructive sleep apnea (OSA) is the most common sleep-disordered breathing condition. Patients with OSA symptoms are often not diagnosed clinically, which is a concern, given the health and safety risks associated with unmanaged OSA. …”
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The Effect of Age on Clinical and Laboratory Parameters in Reproductive Age Women with Endometrial Polyps by Aytekin Tokmak, Ebru Ersoy, Ali Özgür Ersoy, Esra Yaşar Çelik, Ali İrfan Güzel, Mustafa Uğur

“…RESULTS: The mean age of patients in the study and control groups were 45.2±3.5 and 30.6±4.9 years, respectively (p<0.001). …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson&rsquo;s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Emerging evidence suggests a strong link between moderate to severe TBI and an elevated risk of PD, though the underlying mechanisms remain poorly understood.Materials and Methods: Common differentially expressed genes (DEGs) were identified in GEO datasets of patients with traumatic brain injury (TBI) and Parkinson’s disease (PD). …”
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