Leadership Perceptions, Educational Struggles and Barriers, and Effective Modalities for Teaching Vertigo and the HINTS Exam: A National Survey of Emergency Medicine Residency Prog... by Mary McLean, Justin Stowens, Ryan Barnicle, Negar Mafi, Kaushal Shah

“…Subtopic teaching struggles with regard to HINTS were head impulse test and test-of-skew conduction and interpretation, selection of the correct patients, and overall HINTS interpretation. Teaching barriers centered around lack of faculty expertise, concern for poor HINTS reproducibility, and lack of resources. …”
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Global prevalence of platelet-type von Willebrand disease by Omid Seidizadeh, Andrea Cairo, Maha Othman, Flora Peyvandi

“…This novel finding suggests that a large number of PT-VWD patients are still under- or misdiagnosed.…”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…ANV419 is currently in Phase 1/2 clinical development and may provide cancer patients with a wider therapeutic window than aldesleukin.…”
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Analysis of antimicrobial resistance and clinical features of Staphylococcus aureus-infected bone and joint infections in children by Xingguang Chen, Ting Zhuang, Chengda Zou, Yao Liu, Qian Sun, Mengxia Li, Wen Zheng, Chaochen Zhao, Xiaodong Wang

“…There were no significant differences in gender, age, infection site, clinical symptoms, laboratory indicators, hospital stay, or surgical intervention between MSSA and MRSA groups (p > 0.05). However, patients with positive X-ray findings were more likely to have MRSA infections (p = 0.033). …”
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Frequency and consequences of violence and aggression towards employees in the German healthcare and welfare system: a cross-sectional study by Claudia Peters, Albert Nienhaus, Anja Schablon, Annett Zeh, Dana Wendeler, Claudia Wohlert, Melanie Harling

“…Objectives In this study, the frequency and consequences of aggressive assaults on employees in the German healthcare and welfare system were investigated.Design A retrospective cross-sectional study.Setting Employees in the German healthcare system and their experiences of violence and aggression were examined in this study.Participants The sample consisted of 1973 employees from 39 facilities (6 facilities for the disabled, 6 hospitals and 27 outpatient and inpatient geriatric care facilities) who have regular contact with patients or clients.Main outcome measures The frequency of physical and verbal violence towards employees and the consequences of aggressive assaults were analysed.Results 56% of respondents had experienced physical violence and 78% verbal aggression. …”
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Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals by Mansour Abdullah Alghamdi, Laith AL-Eitan, Rasheed Ibdah, Islam Bani Khalid, Salma Darabseh, Maryam Alasmar, Asaad Ataa

“…<i>Materials and Methods</i>: This research involved 200 hypertensive patients and 224 healthy controls. Whole blood samples were collected from each participant, and genomic DNA was extracted. …”
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Mitochondrial DNA from endothelial cells activated the cGAS-STING pathway and regulated pyroptosis in lung ischaemia reperfusion injury after lung transplantation by Ying-nan Ju, Hu Li, Zi-peng Zhuo, Qing Yang, Wei Gao

“…Objective: Cell dysfunction and death induced by lung ischaemia–reperfusion injury (LIRI) are the main causes of death in transplant patients. Activation of the cGAS-STING-induced immune response and death plays a critical role in multiple organ injuries. …”
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Impact of Oseltamivir and Diabetes Development by Bor-Show Tzang, Chih-Chen Tzang, Pei-Hua Chuang, I-Ying Kuo, Yu-Chun Pan, Pei-Hsun Wu, Tsai-Ching Hsu

“…<b>Methods</b>: This retrospective cohort study utilized data from the Taiwan National Health Insurance Research Database (NHIRD), including 1,631,968 patients (815,984 oseltamivir users) between 1 January 2009 and 28 December 2018. …”
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Relationship between triglyceride levels and different snoring states: a systematic review and meta-analysis by Fei-Fei Hou, Bei-Bei Wang, Ye Chen, Qiong Wang, Qiong Wu, Li-Na Yan

“…The specific pathogenesis of elevated TG levels in snoring patients is still unclear. Therefore, we performed this meta-analysis to evaluate the relationship between snoring and elevated TG levels. …”
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Epidemiological Trends and Attributable Risk Burden of Cervical Cancer: An Observational Study from 1990 to 2019 by Hu Yao, Chen Yan, He Qiumin, Zhou Li, Ai Jiao, Li Xin, Li Hong

“…The incidence and mortality in women aged 20 to 39 were relatively stable, whereas an upward trend existed in patients aged 40 to 59. The global cervical cancer incidence rate increased from 335642 in 1990 to 565541 in 2019 (an increase of 68.50%, with an average annual growth rate of 2.28%), while the age-standardized incidence rate (ASIR) showed a slight downward trend of 14.91/100000 people (95% uncertainty interval [UI], 13.37-17.55) in 1990 to 13.35/100,000 persons (95% UI, 11.37-15.03) in 2019. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Conclusion We identify and validate a novel BMR-related prognostic signature comprising 5 DEGs for LUAD patients. Our data might provide a new molecular target for LUAD treatment.…”
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Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers by Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods, Xiaomin Fan

“…Monoclonal antibody drugs with ADCC activity have shown clinical benefit and improved outcomes for patients with certain types of cancer. CD16a, a Fc gamma III receptor, is the major component that is responsible for the ADCC activity of NK cells. …”
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Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma by Suning Huang, Gang Chen, Yiwu Dang, Long-Hua Chen

“…One hundred and twenty-five samples of glioma patients and 18 cases of normal brain tissues were recruited. …”
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TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma by Hongsheng Lu, Chumeng Zhu, Yanyun Ruan, Lilong Fan, Kena Wei, Zhaohui Yang, Qi Chen

“…Analysis of the clinicopathological characteristics of PTC patients showed that high TFE3 expression was significantly correlated with lymph node metastasis. …”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…Autoantibodies against citrullinated IGF2BP1 are further detected in serum and synovial fluid samples from RA patients, which are positively correlated with erythrocyte sedimentation rate (ESR) and disease activity score 28 (DAS28). …”
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Translation of a Diabetes Remission Service into Australian Primary Care: Findings from the Evaluation of DiRECT-Australia by Ritesh Chimoriya, Kimberly Mitlehner, Chee L. Khoo, Uchechukwu Levi Osuagwu, Russell Thomson, Lei Si, Michael Lean, David Simmons, Milan K. Piya

“…This study was aimed at evaluating the translation of the DiRECT intervention into an Australian primary care setting. Methods. All patients enrolled in the DiRECT-Australia Type 2 Diabetes Remission Service in a region of Sydney (Macarthur region, South Western Sydney, Australia) were included. …”
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Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative cl... by James D Berry, Melissa Hagan, Jeffrey Zhang, Ying Liu, Malgorzata Ciepielewska

“…Background: IV edaravone is US FDA approved for the treatment of ALS and was shown in clinical trials to slow the rate of physical functional decline. Patients & methods: This retrospective observational analysis included PALS continuously enrolled in Optum’s Clinformatics Data Mart between 8 August 2017 and 31 December 2021. …”

1990–2041 Global burden of Burkitt lymphoma with 20 years forecast: A systematic analysis using the global burden disease of study of 2021 by Chengyun Dou, Yidan Sang, Hongbo Zhu, Chuangjie Cao

“…Conclusion: The burden of Burkitt lymphoma varies according to different regions and genders, and children of 0–14 years, adults of 50–74 years with Burkitt lymphoma disease as well as male patients need special attention. High body-mass index contributes significantly to Burkitt lymphoma burden in the United States and United Kingdom, but less so in China and India. …”
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Compliance of healthcare workers with the infection prevention and control guidance in tertiary care hospitals: quantitative findings from an explanatory sequential mixed-methods s... by Syed Shariful Islam, Syed Moniruzzaman, M Atiqul Haque, Sarmin Sultana, Marium Salwa, Mohammad Tanvir Islam, Md Maruf Haque Khan

“…Compliance with the IPC guidance was significantly associated with increasing age, female sex, working as a nurse, having non-communicable diseases and history of exposure to patients with COVID-19. Perceived benefits (B=0.039, 95% CI 0.001 to 0.076), self-efficacy (B=0.101, 95% CI 0.060 to 0.142) and cues to action (B=0.045, 95% CI 0.002 to 0.088) were positively associated with compliance. …”
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Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies by Atri Das, Swarnali Khan, Syamal Roy, Shantanabha Das

“…These existing treatments have adverse side effects, inadequate efficacy, and limitations in administering to patients with comorbidities and other underlying diseases. …”
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