Retrospective evaluation of autotransfusion using a cell saver device versus allotransfusion in the perioperative management of acute hemoperitoneum in 43 dogs (2017–2021) by Fabienne Blunschi, Dennis Gluding, Esther Hassdenteufel, Matthias Schneider, Hendrik Lehmann

“…BackgroundCell saver (CS) technology is an increasingly popular approach for autotransfusion in small animal veterinary medicine for the treatment of patients with abdominal hemorrhagic effusion.ObjectiveTo evaluate the utility, effectiveness, and safety of autotransfusions collected with a CS device and to assess whether the use of the CS device reduces the demand for allogenic blood transfusions.Materials and methodsRetrospective study of dogs with acute hemoperitoneum of splenic origin treated surgically. …”
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Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes by Gokhan Gonen, Yasam Kemal Akpak, Murat Muhcu

“…STUDY DESIGN: This was a retrospective cohort study including 1516 women who delivered a singleton pregnancy at GATA Haydarpasa Education Hospital from 2006 to 2009. Patients with multiple pregnancies, chromosome aberrations, or fetal anomalies were excluded. …”
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Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach by Liliana Sachelarie, Ioana Scrobota, Ioana Romanul, Raluca Iurcov, Georgiana Ioana Potra Cicalau, Liana Todor

“…<i>Materials and Methods</i>: In this pilot study, 80 patients with moderate-to-severe periodontitis were assigned to two groups. …”
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Potential Modulatory Role of Phoenixin-14 in Epithelial–Mesenchymal Transition of Endometriotic 12Z Cells by Karolina Iwona Kulinska, Magdalena Wierzbicka, Anna Dera-Szymanowska, Krzysztof Szymanowski, Mirosław Andrusiewicz, Maria Wołuń-Cholewa

“…<b>Methods</b>: This study investigates the effects of phoenixin-14 (PNX-14), a neuropeptide found at reduced levels in endometriosis patients, on the expression of two molecular EMT markers, CDH1 (E-cadherin) and THBS2 (thrombospondin 2), as well as cell viability in the endometriosis-derived 12Z cell line. …”
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Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren by Anna Krahel, Elzbieta Paszynska, Justyna Otulakowska-Skrzynska, Szymon Rzatowski, Amadeusz Hernik, Agnieszka Slopien, Tomasz Hanć, Paula Szczesniewska, Ewa Bryl, Yves Boucher, Marta Tyszkiewicz-Nwafor, Maria Gawriolek, Monika Dmitrzak-Weglarz

“…The use of easily accessible biomarkers for assessing young patients’ health is weighty. This cohort study is aimed at measuring stress/immune biomarkers in the saliva of healthy school-age children and comparing subgroups according to age, sex, and stress perception. …”
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A Randomized Placebo-Controlled Dose-Response Trial of Muvz&trade; for Knee and Low-Back Support in Physically Active Adults by Kalman D, Srivastava S, Desale A, Chatte Snr MD, Nalavade RJ, Shah Snr KM, Karvir S, Bhasale S

“…Ltd, Morya House, 118-B, off Link Road, Andheri West, Mumbai, Maharashtra, 400053, India, Tel +91 9619477885, Email shalini.s@vediclifesciences.comPurpose: The current study aimed to investigate the dose-response efficacy and safety of MuvzTM (E-PR-01, a blend of V. negundo and Z. officinale) in 400 mg (High-dose [HD]) and 200 mg (Low-dose [LD]) of daily dose in physically active adults in 90 days.Patients and Methods: The study included 157 adults aged 40– 60 having knee/low back joint discomfort. …”
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Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank by Ji He, Yanmin He, Qigang Zhan, Zhipan Wu, Qi Sheng, Wei Zhang, Faming Zhu

“…Results Thirteen HLA-A, -B, and -DRB1 and 11 HLA-A, -B, -C, -DRB1, and -DQB1 haplotype homozygotes were observed among the stored umbilical CB units which were as HLA zero-mismatched iPSC donors cumulatively matched 37.01% and 32.99% of 5421 potential patients respectively. The analysis showed that 100 distinct HLA-A, -B, and -DRB1 and HLA-A, -B, -C, -DRB1, and -DQB1 homozygous haplotypes would cover 72.74% and 67.87% of Chinese populations, respectively, and 600 HLA-A, -B, -C, -DRB1, and -DQB1 homozygous haplotypes would cover more than 90% of Chinese populations. …”
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Surveillance and characteristics of vancomycin-resistant Enterococcus isolates in a Chinese tertiary hospital in Shenzhen, 2018 to 2024 by Hongwei Shen, Qiaomin Zhang, Shaobo Li, Tingting Huang, Wen Ma, Daming Wang, Peng Li

“…The majority of the VRE strains were isolated from urine (25/34, 73.5%), and the highest detection rate (9.1%) of VRE infections was observed in the patients aged ≥75 y. In excess of 90% of VRE isolates exhibited resistance to ciprofloxacin (97.1%) and levofloxacin (97.1%), followed by ampicillin (94.1%) and penicillin (94.1%). …”
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A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome by Kentaro Tojo, Takuya Yazawa

“…Abstract Although alveolar hyperoxia exacerbates lung injury, clinical studies have failed to demonstrate the beneficial effects of lowering the fraction of inspired oxygen (FIO2) in patients with acute respiratory distress syndrome (ARDS). …”
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Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus by S. N. Shchelkunov, T. V. Bauer, S. N. Yakubitskiy, A. A. Sergeev, A. S. Kabanov, S. A. Pyankov

“…As a result, it can cause a diminishing of the immune response after administration of attenuated virus to patients at standard doses. The gene for thymidine kinase is frequently used for insertion/inactivation of foreign genes and it causes virus attenuation. …”
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Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease by Wang H, Zhou F, Shen M, Ma R, Yu Q

“…These complex causes make it difficult to achieve a complete cure. Patients with IBD frequently experience recurrent abdominal pain and bloody diarrhea, while severe cases may result in intestinal obstruction, perforation, and cancer. …”
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PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration by Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang

“…The findings suggested that the expressions of PDE4B, ASCL4, and TRFC were significantly upregulated, and the expression of Nrf2 was significantly downregulated in nucleus pulposus (NP) tissues from human IDD patients dependent on IDD degeneration. Overexpression of PDE4B (PDE4B-OE) in NP cells upregulated the expression of ASCL4 and TRFC, and downregulated the expression of Nrf2. …”
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The Impact of Gestational Diabetes Mellitus on the Development of Preeclampsia in Twin Pregnancies: A Retrospective Cohort Study Conducted at a Tertiary Hospital by Wu H, Zhang L, Xie Z, Cai H, Zhang J, Yu L

“…Hanglin Wu, Lin Zhang, Zhen Xie, Hongxia Cai, Jindi Zhang, Liming Yu Department of Obstetrics and Gynecology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Liming Yu, Department of Obstetrics and Gynecology, Hangzhou Women’s Hospital, No. 369 Kun Peng Road, Hangzhou, Zhejiang, People’s Republic of China, Email cxlm770522@sina.comPurpose: This study aimed to examine the effects of gestational diabetes mellitus (GDM) on the risk of pregnancy complications in twin pregnancies and to investigate the relationship between glycemic levels and the risk of preeclampsia (PE) and abnormal fetal growth.Patients and Methods: A retrospective cohort study of 736 twin pregnancies was conducted at a tertiary hospital. …”
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Epidemiological Study of Hepatitis B, C and HIV Cases among the Foreigners Visiting Sulaimani City from 2013 Through 2016 by Mohammed Omer Mohammed, Asan Baram Hasan, Fenk Bakir Maarouf

“…In 2016 the highest prevalence of HBV infection was among Syrians which was 2.5% while highest HCV prevalence was among Europeans 0.82%. Ages of the patients ranged between (18-65) years, 85.4% were males, 65.2% of males and 45.7% of females were married. …”
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Esophageal Impedance-pH Monitoring and Pharyngeal pH Monitoring in the Diagnosis of Extraesophageal Reflux in Children by Anna Plocek, Beata Gębora-Kowalska, Jakub Białek, Wojciech Fendler, Ewa Toporowska-Kowalska

“…MII-pH and Dx-pH were conducted concurrently in all patients. A total of 1228 reflux episodes were recorded by MII-pH. …”
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Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…PFKFB3 represents a promising therapeutic target for overcoming PARPi resistance and improving outcomes in OC patients.…”
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Development of a prognostic nomogram for ocular melanoma: a SEER population-based study (2000–2021) by Miyun Zheng, Miyun Zheng, Maodong Xu, Maodong Xu, Mengxing You, Mengxing You, Zhiqing Huang, Zhiqing Huang

“…The combined use of ROC curve analysis, calibration plots, DCA, 10-fold cross-validation, and machine learning confirmed the strong predictive performance of the nomogram for survival outcomes in patients with OM.…”
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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections by Merlis P. Alvarez-Berrios, Lisa M. Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

“…Invasive candidiasis (IC) remains as a major cause of morbidity and mortality in critically ill patients. Amphotericin B (AmB) is one of the most effective antifungal agents commonly used to treat this infection. …”
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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…Advanced stages of the disease are usually very aggressive, and most are treated with chemotherapeutic drugs that generally cause side effects in these patients. However, additional therapeutic targets such as the IL6R/STAT-3 axis and TIGIT have been proposed, mainly due to their relevance in the development of PCa and regulation of NK cell-mediated cytotoxicity. …”
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Perceptions and reflections of embryo donation recipients: a qualitative follow-up study by Seungho Lee, Salomeh Salari, Mona El-Gayar, Joshua Mangels, Rebecca Flyckt, Jody Madeira, Susan Klock, Steven R Lindheim

“…This previous group was a cross-sectional, survey-based study of psychosocial outcomes of children born via embryo donation. The majority of patients (92%) identified as Christian/Catholic.Themes were identified in participants’ responses to questions regarding general perceptions of embryo donation, decision-making process, disclosure and children’s psychosocial adjustment.Results Of the 118 participants from the quantitative survey-based study who volunteered for this qualitative study, 28 individuals (24%) participated in the phone interview before thematic saturation was reached. …”
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