Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale as a Novel Tool to Measure Disease Progression by Can Sun, Yong Chen, Lu Xu, Wenjing Wang, Nan Zhang, Christina N. Fournier, Nan Li, Dongsheng Fan

“…Clinical characteristics and baseline ROADS, ΔROADS, ALSFRS-R, and ΔFRS of patients were collected. Participants were followed for 18 months to assess time to tracheostomy and survival. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…Diabetic nephropathy (DN) is one of the most serious and frequent complications among diabetes patients and presently constitutes vast the cases of end-stage renal disease worldwide. …”
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Protocol for a living systematic review for the management of concussion in adults by Mark Bayley, Diana Velikonja, Shawn Marshall, Alexander Lithopoulos, Dorothyann Curran, Lisa Fischer, Christopher Knee, Julia Lauzon, Margaret Nevison

“…A living systematic review that is updated as evidence becomes available is the ideal research activity to inform a living guideline targeting clinicians and patients. The purpose of this paper is to present the protocol of an ongoing living systematic review for the management of adult concussion that will inform living guidelines building off the Guideline for Concussion/Mild Traumatic Brain Injury and Persistent Symptoms: third Edition.Methods and analysis The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol guidelines were followed in the reporting of this systematic review protocol. …”
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A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer by Dali Xiong, Jiaran Li, Li Li, Fuhao Xu, Tao Hu, He Zhu, Xiaohui Xu, Yawen Sun, Shuanghu Yuan

“…Results: Twenty studies involving 1,283 patients with liver cancer were included. The results showed that indocyanine green fluorescence imaging significantly reduced intraoperative blood loss [Weighted mean difference (WMD), –88.75; 95 % CI, –128.48 to –49.02, p < 0.05], transfusion rate [Odds ratios (OR), 0.5; 95 % CI, 0.36–0.7, p < 0.05], hospital stay duration [WMD, –1.11; 95 % CI, –1.79 to –0.43, p < 0.05], and the overall complication rate [OR, 0.59; 95 % CI, 0.44–0.79, p < 0.05]. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…This study investigates the role and potential mechanisms of metallothionein 1B (MT1B) in MASH through bioinformatics analysis and experimental validation. quantitative reverse transcription PCR and Western blot analyses confirm that MT1B expression is significantly downregulated in liver tissues of MASH patients, in high-fat diet–induced mouse models, and in hepatocytes induced by FFAs. …”
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Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy by Qianqian Yan, Zihao Zhao, Dongwei Liu, Jia Li, Shaokang Pan, Jiayu Duan, Zhangsuo Liu

“…This study aimed to identify the optimal cross-talk genes, potential pathways, and mutual immune-infiltrating microenvironments between IBD and IgAN to elucidate the linkage between patients with IBD and IgAN. The IgAN and IBD datasets were obtained from the Gene Expression Omnibus (GEO). …”
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An Efficient and Hybrid Deep Learning-Driven Model to Enhance Security and Performance of Healthcare Internet of Things by Muhammad Babar, Muhammad Usman Tariq, Basit Qureshi, Zabeeh Ullah, Fahim Arif, Zahid Khan

“…Third, the past medical records of the patients are used to train the DL model. It then makes an informed decision about whether to send the data to the fog layer. …”
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Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis by Litong Ran, Xiufei Liu, Yongfeng Tian, Jiaran Zhu, Zhengyuan Gong, Qiao Qiao, Xin Jiang, Yuren Wang, Guojun Yang, Hongting Zheng, Yi Zheng, Hua Qu

“…Here, we profiled thyroid in situ protein alterations in fine-needle aspiration biopsy samples from SAT patients using proteomic analysis and uncovered 57 differentially abundant proteins. …”
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Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts by Sara Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone, M V Iorio

“…Expressed at higher levels in primary triple-negative breast CAFs versus NFs isolated from patients, miR-9 improves indeed migration and invasion capabilities when transfected in immortalized NFs; viceversa, these properties are strongly impaired in CAFs upon miR-9 inhibition. …”
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

“…Using the putamen (a subnucleus of the striatum) as an indicator for convergent genetic risk of schizophrenia, 63 unaffected first-degree relatives of patients (22.08 ± 4.80 years) with schizophrenia (UFR-SZ) were stratified into two groups. …”
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Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurpo... by Arnob Sarker, Burhan Uddin, Reaz Ahmmed, Sabkat Mahmud, Alvira Ajadee, Md. Al Amin Pappu, Md. Abdul Aziz, Md. Nurul Haque Mollah

“…So identifying mutated oncodriver genes which could be used as potential drug target is essential in order to develop effective new therapeutic drugs as well as better prognosis for GBM patients. In this study, we analyzed whole exome sequencing (WES) profiles of NCBI database on GBM and matched-normal (control) samples originated from astrocyte like neural stem cells (NSC) of subventricular zone (SVZ) to explore GBM-causing mutated oncodriver genes, since SVZ is considered as the origin of GBM development. …”
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Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross‐Sectional Phase of Tehran Cohort Study by Pooria Ahmadi, Sajjad Ahmadi‐Renani, Parmida Sadat Pezeshki, Sepehr Nayebirad, Arash Jalali, Akbar Shafiee, Aryan Ayati, Arian Afzalian, Farshid Alaeddini, Soheil Saadat, Farzad Masoudkabir, Ali Vasheghani‐Farahani, Saeed Sadeghian, Mohamamdali Boroumand, Abbasali Karimi, Boshra Pourbashash, Kaveh Hosseini, Frits R. Rosendaal

“…Since these abnormalities have been associated with poor outcomes, screening patients with cardiovascular risk factors with an ECG may distinguish high‐risk individuals who require appropriate care and follow‐up.…”
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Lesion-specific coronary artery calcium score to predict stent underexpansion by Wentao Yang, Ke Xu, Xi Fu, Weifeng Zhang, Ziyong Hao, Zhenchi Sang, Lisheng Jiang, Xingbiao Qiu, Shengxian Tu, Linghong Shen, Ben He

“…We aimed to determine the association between lesion-specific CAC score and stent underexpansion.MethodsIn this retrospective observational study, we included 416 lesions from 359 patients who underwent intravascular ultrasound (IVUS)-guided stent implantation. …”
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Determinants of Vitamin D Levels in Italian Children and Adolescents: A Longitudinal Evaluation of Cholecalciferol Supplementation versus the Improvement of Factors Influencing 25(... by Stefano Stagi, Paola Pelosi, Massimo Strano, Giovanni Poggi, Cristina Manoni, Maurizio de Martino, Salvatore Seminara

“…This paper aims to assess 25(OH)D levels in Italian children and adolescents identifying risk factors for 25(OH)D deficiency and to evaluate whether a normal 25(OH)D value can be restored in 25(OH)D-deficient patients. Methods. We evaluated 25(OH)D levels in 679 Italian children and adolescents (≤10, 11–20, 21–30, and >30 ng/mL were defined as severe deficiency, deficiency, insufficiency, and sufficiency, resp.). …”
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The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases by Jagriti Verma, Md Tanveer Anwar, Bodo Linz, Steffen Backert, Suneesh Kumar Pachathundikandi

“…While the development of <i>H. pylori</i>-associated intestinal metaplasia is accompanied by an increase in Bacteroides, the stomachs of GC patients are dominated by Firmicutes such as <i>Lactobacillus</i> and <i>Veillonella</i>, constituting up to 40% of the total microbiota, and by Bacteroidetes such as <i>Prevotella</i>, whereas the numbers of <i>H. pylori</i> are decreasing. …”
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Improved Predictability of Diagnosis and Prognosis Using Serum‐ and Tissue‐Derived Extracellular Vesicles From Bulk mRNA Sequencing in Pancreatic Ductal Adenocarcinoma by Qian Zhu, Zhang Chen, Ming Tian, Xin Yan, Xiangdong Gongye, Zhicheng Liu, Anbang Zhao, Zhiyong Yang, Yufeng Yuan

“…Materials & Methods Exosomes were isolated from healthy individuals and PDAC patients via tissue and serum samples, then identified by analyzing their particle size and protein content. …”
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Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study by Jing Qian, Jiahao Zhu, Yifan Wang, Ruoqi Dai, Jingyou Miao, Ye Yang, Wenxia Zhao, Jing Wang, Lilu Ding, Dan Zhou, Min Yu, Yingjun Li

“…Conclusion: Long-term exposure to air pollution was associated with an increased risk of OA in the population and poorer survival outcomes for OA patients, with epigenetic changes in GDF5 potentially playing a role in the underlying mechanisms.…”
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Factors affecting the implementation of guideline-based prophylactic antiemetic therapy for chemotherapy-induced nausea and vomiting in Japan: a protocol for a hospital-based quali... by Yosuke Uchitomi, Junko Saito, Maiko Fujimori, Taichi Shimazu, Ayako Okuyama, Sadamoto Zenda, Ayumu Matsuoka, Akiko Yaguchi-Saito, Yuki Kaji, Miyuki Odawara, Aki Otsuki

“…Introduction Chemotherapy-induced nausea and vomiting (CINV) decrease patients’ quality of life and negatively impact treatment outcomes. …”
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Establishing a preoperative predictive model for gallbladder adenoma and cholesterol polyps based on machine learning: a multicentre retrospective study by Yubing Wang, Chao Qu, Jiange Zeng, Yumin Jiang, Ruitao Sun, Changlei Li, Jian Li, Chengzhi Xing, Bin Tan, Kui Liu, Qing Liu, Dianpeng Zhao, Jingyu Cao, Weiyu Hu

“…Materials and methods We retrospectively analysed the patients’ clinical baseline data, serological indicators, and ultrasound imaging data. …”
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Towards PErsonalised PRognosis for children with traumatic brain injury: the PEPR study protocol by Jaap Oosterlaan, Marsh Königs, Job B M van Woensel, Marc Engelen, Marjan E Steenweg, Petra J W Pouwels, Cece C Kooper, Hilgo Bruining, Arne Popma, Dennis R Buis, Maayke Hunfeld

“…However, outcome varies between patients and is mediated by complex interplay between demographic factors, premorbid functioning and (sub)acute clinical characteristics. …”
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