Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease by Maxime Deslande, Francesc Puig-Castellvi, Inés Castro-Dionicio, Romina Pacheco-Tapia, Violeta Raverdy, Robert Caiazzo, Guillaume Lassailly, Audrey Leloire, Petros Andrikopoulos, Yasmina Kahoul, Nawel Zaïbi, Bénédicte Toussaint, Frédérik Oger, Nicolas Gambardella, Philippe Lefebvre, Mehdi Derhourhi, Souhila Amanzougarene, Bart Staels, François Pattou, Philippe Froguel, Amélie Bonnefond, Marc-Emmanuel Dumas

“…Methods: We characterised liver biospies from 318 patients with obesity using RNAseq and metabolomics in liver and plasma to derive associations among hepatic hippurate, hepatic gene expression and MASLD and phenotypes. …”
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Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis by Yinyin Wang, Bingdong Zhang, Chunhua He, Bo Tian, Sihan Liu, Jianghua Li, Jiayu Wang, Shigao Yang, Bingtao Zhu, Xiaoguang Wang, Zhijie Chang, Chenxi Cao

“…We demonstrated that co-expression of NOK and EGFR correlated with tumor malignant stages in breast cancer patients. Our finding introduces a new cross interaction manner of EGFR-NOK via juxtamembrane (JM) domains and kinase domains, uncovers a mechanism by which NOK coordinates EGFR to enhance EGF-STAT3/5 signaling during tumorigenesis and metastasis, and proposes a potential strategy for targeting NOK-EGFR in breast cancer treatment.…”
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A machine learning-based model for predicting paroxysmal and persistent atrial fibrillation based on EHR by Yuqi Zhang, Sijin Li, Peibiao Mai, Yanqi Yang, Niansang Luo, Chao Tong, Kuan Zeng, Kun Zhang

“…Early and individualized intervention strategies based on our model may help to improve clinical outcomes in AF patients.…”
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Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…To address this unmet need, global metabolomic profiling was performed on tumor tissue and paired serum samples from patients with treatment‐naïve (TN; n = 18) and neoadjuvant leucovorin calcium (folinic acid), fluorouracil, irinotecan hydrochloride and oxaliplatin (FOLFIRINOX)‐treated (NAT; n = 17) PDAC using liquid chromatography mass spectrometry. …”
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Aerobiology matters: Why people in the community access pollen information and how they use it by Danielle E. Medek, Constance H. Katelaris, Andelija Milic, Paul J. Beggs, Edwin R. Lampugnani, Don Vicendese, Bircan Erbas, Janet M. Davies

“…Whilst responses suggested this helped inform behaviours linked to allergen avoidance, further education strategies on allergic rhinitis control are needed to support patients who self‐manage their condition.…”
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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial by Mahshad Shafiee, Amir Sadeghi, Fateme Ghafouri-Taleghani, Maryam Nilghaz, Maryam Ghods, Behnaz Narimani, Azita Hekmatdoost, Atoosa saidpour

“…This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight and obese patients with MAFLD. Forty-six participants were randomly assigned to either the intervention group (TRF with LOV diet) or the control group, with 21 participants completing the 12-week study in each group. …”
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Association of Wrist Circumference and Waist-to-Height Ratio with Cardiometabolic Risk Factors among Type II Diabetics in a Ghanaian Population by Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya

“…This cross-sectional study involved 384 diabetic patients at Begoro District Hospital, Ghana. Blood pressure, anthropometrics, and biochemical indices were measured. …”
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Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study by Aishwarya Raje, Abhijit R. Rozatkar, Urvakhsh Meherwan Mehta, Ritu Shrivastava, Ameya Bondre, Manaal Amir Ahmad, Anshika Malviya, Yogendra Sen, Deepak Tugnawat, Anant Bhan, Tamonud Modak, Nabagata Das, Srilakshmi Nagendra, Erlend Lane, Juan Castillo, John A. Naslund, John Torous, Soumya Choudhary

“…Using smartphones to assess cognition in schizophrenia offers the advantages of convenience in that patients can complete assessments outside of the clinic, temporality in that longitudinal trends can be identified, and contextuality in that cognitive scores can be interpreted with other measures captured by the phone (e.g. sleep). …”
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ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Low levels of TNFIP3 protein may be associated with improved survival probability in ESCC patients.…”
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Practice and factors affecting informed consent among healthcare workers for major surgical procedures at Gurage zone hospitals, South Ethiopia, 2022: a facility-based cross-sectio... by Haimanot Abebe, Bitew Tefera Zewudie, Yibeltal Mesfin, Shegaw Geze Tenaw, Daniel Tsega, Bogale Chekole, Zebene Mekonnen, Shegaw Tesfa Mengist, Agere Aynalem, Tadele Lankrew, Yihenew Sewale, Muche Argaw, Tadesse Sahle

“…Objective This study aimed to assess the informed consent practice process and associated factors among healthcare workers for major surgical procedures at Gurage zone hospitals, in 2022.Methods and materials Institution-based cross-sectional study was employed.Settings This study was conducted in Gurage zone hospitals.Participants All healthcare workers who have been working in Gurage zone hospitals of surgical, operation rooms and obstetrics/gynaecology wards had exposure to patients who had undergone surgery during the study periodOutcome The primary outcome of the study was the practice of informed consent practice among healthcare workers in Gurage zone hospitals.Result A total of 448 study participants were involved in this study giving a response rate of 98%. …”
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Phenotypic Presentation of Children with Joint Hypermobility: Preclinical Signs by Mateus Marino Lamari, Neuseli Marino Lamari, Michael Peres de Medeiros, Gerardo Maria de Araújo Filho, Adriana Barbosa Santos, Matheus Gomes Giacomini, Vitor Roberto Pugliesi Marques, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino

“…A total of 52.4% of the children had BS > 6, with a higher prevalence among girls (60.8%) compared to boys (40.0%); a difference statistically significant (<i>p</i> = 0.024, Fisher’s exact test). Thirty-two patients (27.4%) had luxations/subluxations with the higher scores. …”
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UTE MRI technical developments and applications in osteoporosis: a review by Soo Hyun Shin, Hee Dong Chae, Hee Dong Chae, Arya Suprana, Arya Suprana, Saeed Jerban, Eric Y. Chang, Eric Y. Chang, Lingyan Shi, Robert L. Sah, Jeremy H. Pettus, Gina N. Woods, Jiang Du, Jiang Du, Jiang Du

“…The disease results in serious long-term disability and death in a large number of patients. Bone mineral density (BMD) measurement is the current standard in assessing fracture risk; however, the majority of fractures cannot be explained by BMD alone. …”
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HIV and the gut microbiome: future research hotspots and trends by Zhen Wu, Zhan-Peng Xie, Xin-Xin Cui, Xiang-Bin Sun, Fang-Yi Zhao, Nuo Wang, Yu Li, Yu Li, Yu Li, Haixia Wang, Haixia Wang, Haixia Wang, Li Zhang, Li Zhang, Li Zhang, Jing Shen, Fulei Chen, Haogang Sun, Jia He, Jia He, Jia He

“…Modulating the gut microbiome of patients may improve this situation, yet the specific association mechanisms between HIV and the gut microbiome remain unclear. …”
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Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers by Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo

“…Methods We performed a comparative single‐cell RNAsequencing (scRNA‐seq) analysis on tumour and adjacent para‐tumour tissues fromMPLC and SPLC patients to comparatively evaluate their immunological landscapes.Additionally, multiplex immunofluorescence (mIF) staining and independentvalidation datasets were used to confirm findings. …”
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Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…In summary, CoQ10 could be an additional treatment for obesity-related infertility in patients with normal metabolic profiles. While CoQ10 does not affect metabolic parameters influenced by obesity, crucial for reproductive issues and offspring health, it is recommended as part of a treatment plan that includes a balanced diet and increased physical activity for obese individuals with metabolic alterations seeking pregnancy.…”
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Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium by Paul Denver, Lucas Tortorelli, Karen Hov, Jens Petter Berg, Lasse M. Giil, Arshed Nazmi, Ana Lopez-Rodriguez, Daire Healy, Carol Murray, Robyn Barry, Leiv Otto Watne, Colm Cunningham

“…Here, in human hip-fracture patients, we tested the influence of BCSFB integrity on CSF levels of chemokines and assessed their association with delirium. …”
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Preferences and access to community-based HIV testing sites among men who have sex with men (MSM) in Côte d’Ivoire by Christine Danel, Joseph Larmarange, Lazare Sika, Maxime Inghels, Arsène Kra Kouassi, Serge Niangoran, Anne Bekelynck, Séverine Carilon, Mariatou Koné, Annabel Degrées du Loû

“…Both knowing of and ever visiting an MSM-CBTS were significantly associated with a higher number of HIV tests performed in the past 12 months and having disclosed sexual orientation to one family member.In terms of preferences, 37% of respondents said they preferred undifferentiated HIV testing sites (ie, ‘all patients’ HIV testing sites), 34% preferred MSM-CBTS and 29% had no preference.Those who reported being sexually attracted to women, being bisexual and those who did not know an MSM non-governmental organisation were less likely to prefer MSM-CBTS. …”
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Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Our findings may provide novel targets for diagnosis and therapeutic intervention in lung cancer patients.…”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…The superior CD38 targeting of ISB 1442, at both high and low receptor densities, by its biparatopic design, will enhance proximal CD47 blockade and thus counteract a major tumor escape mechanism in multiple myeloma patients.…”
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Virtual reality and speech analysis for the assessment of impulsivity and decision-making: protocol for a comparison with neuropsychological tasks and self-administered questionnai... by Marta Ruiz, Maria Luisa Barrigon, Antonio Artes, Philippe Courtet, Enrique Baca-Garcia, Jorge Lopez-Castroman, Santiago de Leon-Martinez, Elena Parra-Vargas, Irene Chicchi-Giglioli, Alejandro Albán Porras-Segovia

“…We hypothesise that these innovative tools will be reliable and acceptable by patients, potentially improving the simultaneous assessment of impulsivity and decision-making.Methods and analysis This study will be carried out at the University Hospital Fundación Jiménez Díaz (Madrid, Spain). …”
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