Evaluation of the Safety of Percutaneous Dilational Tracheostomy Compared with Surgical Tracheostomy in the Intensive Care Unit by Yuta Suzuki, Takeshi Suzuki, Yuko Yamamoto, Ayano Teshigawara, Jun Okuda, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata, Takashige Yamada, Hiroshi Morisaki

“…Tracheostomy is a necessary procedure for patients who require long-term mechanical ventilation support. …”
Get full text

Dilated cardiomyopathy signature metabolic marker screening: Machine learning and multi-omics analysis by Xiao-Lei Li, Aibibanmu Aizezi, Yan-Peng Li, Yan-Hong Li, Fen Liu, Qian Zhao, Xiang Ma, Dilare Adi, Yi-Tong Ma

“…Methods: We utilized non-targeted metabolomics with a cross-sectional cohort of age- and sex-matched DCM patients and controls. Metabolomics data were analyzed using orthogonal partial least squares-discriminant analysis (OPLS-DA) and pathway analysis. …”
Get full text

The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women by Xinjun Hu, Shasha Li, Renliang Huang, Ziwei Fu, Chenyu Ma, Zheng Cheng, Hongjun Hu, Qiaomiao Zhou, Frank Petersen, Xinhua Yu, Xinhua Yu, Junfeng Zheng

“…Our study included 490 healthy controls and 492 TB patients who were genotyped for the NCF1 rs201802880 polymorphism.ResultsOur results showed that the NCF1 rs201802880 AA genotype was associated with a reduced risk of TB in women (OR= 0.25, 95% CI: 0.09-0.68, p=0.0023). …”
Get full text

Performance of the AmpliSeq NGS panel in thyroid nodules with indeterminate cytology by Wiame Potonnier, Erell Guillerm, Claude Bigorgne, Cécile Ghander, Malanie Roy, Florence Coulet, François Ansart, Fabrice Menegaux, Laurence Leenhardt, Isabelle Brocheriou, Gabrielle Deniziaut, Camille Buffet

“…Methods: Retrospective, monocentric study including 121 patients with cytologically indeterminate thyroid nodules (Bethesda III, IV and V) who underwent a routine FNA procedure for molecular testing using the AmpliSeq general cancer NGS panel, with an available final histological diagnosis. …”
Get full text

Healthcare waste characteristics and management in regional hospital and private clinic by S. Ajbar El Gueriri, F. El Mansouri, F. Achemlal, S. Lachaal, J. Brigui, A. Fakih Lanjri

“…The survey found gaps in knowledge, attitudes, and daily challenges in waste management practices among the health workers in both facilities.CONCLUSION: The survey findings suggest that the healthcare waste management methods in Tangier are unsafe and may endanger the health workers and patients. The study found that the lack of monitoring and control contributed significantly to noncompliance with good practices. …”
Get full text

Predicting Time in Range Without Hypoglycaemia Using a Risk Calculator for Intermittently Scanned CGM in Type 1 Diabetes by Fernando Sebastian‐Valles, Jose Alfonso Arranz Martin, Julia Martínez‐Alfonso, Jessica Jiménez‐Díaz, Iñigo Hernando Alday, Victor Navas‐Moreno, Teresa Armenta Joya, Maria del Mar delFandiño García, Gisela Liz Román Gómez, Jon Garai Hierro, Luis Eduardo Lander Lobariñas, Carmen González‐Ávila, Purificación deMartinez de Icaya, Vicente Martínez‐Vizcaíno, Miguel Antonio Sampedro‐Nuñez, Mónica Marazuela

“…Methods This retrospective study included 1072 type 1 diabetes patients (49.0% female) from three centres using isCGM systems. …”
Get full text

Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer r... by А. А. Timofeeva, V. I. Minina, A. V. Torgunakova, О. А. Soboleva, R. А. Тitov, Ya. А. Zakharova, M. L. Bakanova, А. N. Glushkov

“…Associations of polymorphisms in the hOGG1 (rs1052133), APEX1 (rs1130409), XPD (rs13181), SOD2 (rs4880), and CAT (rs1001179) genes were studied in 313 nonsmoking postmenopausal patients with luminal B subtype breast cancer. The control group consisted of 233 healthy nonsmoking postmenopausal women. …”
Get full text

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…Detection and monitoring FHAAs are decisive for effectively treating patients. Current FHAA analysis normally identify free FHAAs that bind surface-bound FH using ELISA techniques. …”
Get full text

Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study by Xiaowen Bo, Qiuyu Li, Siyuan Chen, Tian Zhou, Ning Yin, Wenpeng Song, Donghui Zhao, Jinghua Liu, Qian Fan

“…The compilation of research hotspots and emerging trends in this area may provide researchers with more references and assistance in selecting research directions, ultimately benefiting MI/RI patients.…”
Get full text

Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Results Testosterone emerged as a key contributor to phenotypic variability via principal component analysis and was therefore used to further categorize obese patients as having or not having hypogonadotropic hypogonadism (HH). …”
Get full text

Monocyte to High‐Density Lipoprotein Ratio Is Associated With Carotid Plaque: A Retrospective Cohort Study by Shuang Liu, Xinlei Miao, Manling Hu, Ziping Song, Xiaoling Xie, Yuting Sun, Meng Li, Guimin Tang, Song Leng

“…The assessment and management of MHR is helpful for the early detection of patients with CP and the primary prevention of cardiovascular diseases.…”
Get full text

Classification of peripheral vitreoretinal interface lesions using spectral-domain optical coherence tomography with guidance of ultrawide field imaging by Weiwei Zheng, Ying Huang, Ying Huang, Shanshan Qian, Bing Lin, Bing Lin, Shenghai Huang, Shenghai Huang

“…Differences in OCT-based categorization between the same lesion types visualized by UWF imaging were also compared.ResultsOf the total 82 patients, 105 peripheral lesions were included in this study. …”
Get full text

A scientometric visualization analysis of the gut microbiota and gestational diabetes mellitus by Zehao Su, Zehao Su, Lina Liu, Jian Zhang, Jian Zhang, Jingjing Guo, Jingjing Guo, Guan Wang, Xiaoxi Zeng, Xiaoxi Zeng

“…Increasing attention has been given to the impact of probiotic supplementation on metabolism and pregnancy outcomes in GDM patients. Moreover, ongoing research is exploring the potential of the gut microbiota as a biomarker for GDM. …”
Get full text

Exploring the need for fertility education: A cross-sectional study of healthcare professionals and students’ knowledge of fertility and fertility preservation by Ana GALHARDO, Catarina SALVADO, Soraia MONIZ, Marina Cunha, Ilda MASSANO-CARDOSO

“…Conclusions: Overall, despite having some information, professionals and students still lack sufficient knowledge to support their patients. These results highlight the relevance of designing training and information opportunities to enhance knowledge on the topics of fertility awareness and fertility preservation.…”
Get full text

Signatures of lower respiratory tract microbiome in children with severe community-acquired pneumonia using shotgun metagenomic sequencing by Ting-Yu Yen, Ching Hsu, Ni-Chung Lee, Chao-Szu Wu, Hsin Wang, Kuan-Yi Lee, Chia-Ray Lin, Chun-Yi Lu, Mo-Li Tsai, Tzu-Yu Liu, Che Lin, Chien-Yu Chen, Luan-Yin Chang, Feipei Lai, Li-Min Huang

“…Critical cases were patients with respiratory failure requiring endotracheal ventilator support, and severe cases did not require intubation. …”
Get full text

Diagnostic Potential of Multidetector Computed Tomography for Characterizing Small Renal Masses by Maria Elisabetta Mancini, Annamaria Albergo, Marco Moschetta, Mariacristina Angelelli, Arnaldo Scardapane, Giuseppe Angelelli

“…To assess the potential of CT for characterizing small renal tumors. Methods. 76 patients with <4 cm renal tumors underwent CT examination. …”
Get full text

The obesity paradox in osteoporosis risk among older adults is mostly driven by women: a population-based prospective study by Qingfeng Luo, Shiyong Zhang, Zixin Liang, Danni Wang, Yanlin Zhong, Bin Xia, Peng Xie, Can Wang, Jinqiu Yuan, Ziji Zhang, Xingsheng Li

“…A total of 8,998 OP patients were identified during a median follow-up period of 13.7 years. …”
Get full text

Gestational Diabetes Mellitus Does Not Change the Pharmacokinetics and Transplacental Distribution of Fluoxetine and Norfluoxetine Enantiomers by Daniela Miarelli Carvalho, Glauco Henrique Balthazar Nardotto, Gabriela Campos de Oliveira Filgueira, Geraldo Duarte, Ricardo Carvalho Cavalli, Vera Lucia Lanchote, Elaine Christine Dantas Moisés

“…<b>Conclusions</b>: The GDM did not alter the pharmacokinetics of FLX and norFLX enantiomers in patients with good glycemic control evaluated in the third trimester of gestation.…”
Get full text

Enterococcus and Eggerthella species are enriched in the gut microbiomes of COVID-19 cases in Uganda by Carolina Agudelo, David Patrick Kateete, Emmanuel Nasinghe, Rogers Kamulegeya, Christopher Lubega, Monica Mbabazi, Noah Baker, Kathryn Y. Lin, Chang C. Liu, Arthur Shem Kasambula, Edgar Kigozi, Kevin Komakech, John Mukisa, Kassim Mulumba, Patricia Mwachan, Brenda Sharon Nakalanda, Gloria Patricia Nalubega, Julius Nsubuga, Diana Sitenda, Henry Ssenfuka, Giana T. Cirolia, Jeshua T. Gustafson, Ruohong Wang, Moses Luutu Nsubuga, Fahim Yiga, Sarah A. Stanley, Bernard Ssentalo Bagaya, Alison Elliott, Moses Joloba, Ashley R. Wolf

“…Comparison of the COVID-19 patients and their household contacts revealed decreased alpha diversity and blooms of Enterococcus and Eggerthella in COVID-19 cases. …”
Get full text

Screening of Anti-Inflammatory Components of Qin Jin Hua Tan Tang by a Multivariate Statistical Analysis Approach for Spectrum-Effect Relationships by Feipeng Duan, Yisheng Li, Meizhen Zhao, Tianyong Hu, Xinquan Pan, Yue Feng, Fang Ma, Shuqi Qiu, Yiqing Zheng

“…Qing Jin Hua Tan Tang (QJHTT) exerts therapeutic effects in patients with chronic obstructive pulmonary disease (COPD) by alleviating inflammation. …”
Get full text