Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB by P. S. Rao, K. Reed, N. Modi, D. Handler, K. Petros de Guex, S. Yu, L. Kagan, R. Reiss, N. Narayanan, C. A. Peloquin, A. Lardizabal, C. Vinnard, T. A. Thomas, Y. L. Xie, S. K. Heysell

“…METHODS: We enrolled 56 adult patients on treatment for active TB. Serum was collected at 0, 1, 2, 4, 6, and 8 h for measurement of INH concentrations using validated LC-MS/MS methods. …”
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Impact of aging on hepatic reserve after preoperative portal vein embolization in hepatectomy for perihilar cholangiocarcinoma by Shinichi Nakanuma, Takahiro Ogi, Hiroaki Sugita, Ryosuke Gabata, Tomokazu Tokoro, Ryohei Takei, Kaichiro Kato, Satoshi Takada, Mitsuyoshi Okazaki, Isamu Makino, Shintaro Yagi

“…Methods: We enrolled 25 patients who underwent right hepatectomy with percutaneous transhepatic PVE. …”
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Islet Transplantation Reverses Podocyte Injury in Diabetic Nephropathy or Induced by High Glucose via Inhibiting RhoA/ROCK/NF-κB Signaling Pathway by Chongchu Huang, Yi Zhou, Hongjian Huang, Yushu Zheng, Lijun Kong, Hewei Zhang, Yan Zhang, Hongwei Wang, Mei Yang, Xiaona Xu, Bicheng Chen

“…Discovery of signaling pathways affecting podocyte recovery is helpful for individualized efficacy evaluation and targeted therapy of islet transplantation patients.…”
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[18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer by Arnoldo Piccardo, Francesco Fiz, Sergio Righi, Stefano Raffa, Mattia Riondato, Gianluca Bottoni, Matteo Bauckneht, Michela Massollo, Alessio Rizzo, Mehrdad Shoushtari Zadeh Naseri, Pierpaolo Trimboli, Giorgio Treglia

“…Methods: Two authors searched PubMed, CENTRAL, Scopus, Web of Science and the web for studies evaluating the biodistribution and dosimetry of TFB in patients with DTC. General characteristics, technical parameters, procedures’ sensitivities and standards of reference were extracted from the selected studies. …”
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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…This case control study was aimed at comparing the clinical characteristic, β-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection. 140 cases of newly diagnosed T2DM patients were divided into ketosis (62 cases) and nonketotic onset group (78 cases). …”
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Efficacy of dexamethasone or clonidine as adjuvants in interscalene brachial plexus block for preventing rebound pain after shoulder surgery: a randomized clinical trial by Layana Vieira Nobre, Leonardo Henrique Cunha Ferraro, Juscelino Afonso de Oliveira Júnior, Vitória Luiza Locatelli Winkeler, Luis Flávio França Vinhosa Muniz, Hiago Parreão Braga, Plínio da Cunha Leal

“…Methods: This was a multicenter, prospective, parallel grouping, randomized clinical trial conducted with patients receiving a single injection of bupivacaine 0.375% in interscalene block ultrasound guided and general anesthesia for shoulder surgery were randomly assigned to either no additives (control), clonidine (30 mcg), or dexamethasone (4 mg). …”
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Nationwide guideline implementation: a qualitative study of barriers and facilitators from the perspective of guideline organizations by Andrea C. Thoonsen, Anika Gans, Toby T. Broeders, Ilse van Beusekom, Diana M. J. Delnoij, Martine C. de Bruijne, Hanneke Merten

“…The identified barriers and facilitators provide guidance for policymakers to re-evaluate and improve nationwide quality and guideline implementation policies, to eventually improve clinical practice and health outcomes for patients.…”
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Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models by Jichao Wu, Die Huang, Jiefang Li, Jingxing Yi, Yu Lei, Jun Yin

“…Low levels of LMR significantly increase the risk of both cardiovascular disease and all-cause mortality in patients.…”
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Filtration efficiency of medical and community face masks against particles carrying SARS-CoV-2 by Sara Dalvand, Rasul Nasiri, Rasoul Yarahmadi, Farah Bokharaei-Salim, Ali-Asghar Farshad, Somayeh Soleimani-Alyar

“…Air samples were also collected from the breathing zone of COVID-19 patients in hospital settings, both with and without masks. …”
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Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial by Mark Conaway, David R Boulware, Scott K Heysell, Stellah G Mpagama, Christopher C Moore, Alphonce Liyoyo, Conrad Muzoora, Catherine Gitige, Bibie Said, Edwin Nuwagira, Rinah Arinaitwe, Rhina Mushagara, Peter Buzaare, Anna Chongolo, Samuel Jjunju, Precious Twesigye, Megan Null, Tania A Thomas

“…However, anti-TB therapy is often delayed and may not achieve adequate blood concentrations in patients with sepsis. Accordingly, this multisite randomised clinical trial aims to determine whether immediate and/or increased dose anti-TB therapy improves 28-day mortality for participants with HIV and sepsis in Tanzania or Uganda.Methods and analysis This is a phase 3, multisite, open-label, randomised controlled clinical 2×2 factorial superiority trial of (1) immediate initiation of anti-TB therapy and (2) sepsis-specific dose anti-TB therapy in addition to standard of care antibacterials for adults with HIV and sepsis admitted to hospital in Tanzania or Uganda. …”
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Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study by Narges Khanjani, Nino Künzli, Zahra Khorrami, Mohsen Pourkhosravani, Marzieh Eslahi, Maysam Rezapour, Mohammad Esmail Akbari, Heresh Amini, Seyed Mahmood Taghavi-Shahri, Koorosh Etemad

“…The association between air pollutants and leukaemia incidence was analysed by negative binomial regression.Setting Twenty-two districts of Tehran megacity.Participants Patients with leukaemia.Outcome measures The outcome variables were incidence rate ratios (IRR) of acute myeloid and lymphoid leukaemia across the districts of Tehran.Results The districts with higher concentrations for all pollutants were near the city centre. …”
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Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma by Nadia St. Thomas, Benjamin N. Christopher, Leticia Reyes, Reeder M. Robinson, Lena Golick, Xiaoyi Zhu, Eli Chapman, Nathan G. Dolloff

“…Cutaneous T-cell lymphoma (CTCL) is a rare T-cell malignancy characterized by inflamed and painful rash-like skin lesions that may affect large portions of the body’s surface. Patients experience recurrent infections due to a compromised skin barrier and generalized immunodeficiency resulting from a dominant Th2 immune phenotype of CTCL cells. …”
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Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease by Dagmar Berankova, Eva Janousova, Martina Mrackova, Ilona Eliasova, Milena Kostalova, Svetlana Skutilova, Irena Rektorova

“…We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. …”
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Metformin in COVID-19: a magical role beyond the hyperglycemia by Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Sharmila Talukdar, Asmita Dhiman, Manoj Raje

“…Several studies have highlighted the nexus between COVID-19-associated morbidity and diabetes in a wide-ranging class of subjects ranging from pediatric cases to adults and patients with other co-morbidities. Metformin is a mainstay in the treatment of type 2 diabetes (T2D). …”
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Screening for diabetic retinopathy at a health centre in South Africa: A cross-sectional study by Ntokozo Zulu, Patrick Ngassa Piotie, Elizabeth M. Webb, Wezi G. Maphenduka, Steve Cook, Paul Rheeder

“…Conclusion: The study revealed that while DR was not highly prevalent among PHC patients with diabetes, there was a significant referral rate for other ocular complications. …”
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Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels by Jeong Min Song, Ala Aiob, Ala Aiob, Kidong Kim, Kidong Kim, Kwang Beom Lee, Sokbom Kang, Chae Hyeong Lee, Se Ik Kim, Nam Kyeong Kim, Dae Hoon Jeong

“…Recurrence-free survival (RFS) was estimated using the Kaplan–Meier method and compared using the log-rank test.ResultsSeventy-three patients were included. Of 62 women who underwent lymphadenectomy, only two (3.2%) had lymph node metastasis. …”
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Clinical Pregnancy and Miscarriage Rates in relation to Vitamin D Supplementation among women with Hyper Androgenic PCOS: A prospective study by Sherif Sobhy Menshawy Khalifa, Wael Gaber Eldamaty, Ahmed Tharwat Abo Dakika, Mohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Hassan Elfiky, Ghada Adel Hegazy

“…Methods A prospective study was conducted on 200 patients with hyper androgenic polycystic ovarian disease, at outpatient infertility clinic, Menoufia University Hospital during from March 2021 till March 2022. …”
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Trabecular Bone Remodeling after Lateral Lumbar Interbody Fusion: Indirect Findings for Stress Transmission between Vertebrae after Spinal Fusion Surgery by Naoki Segi, Hiroaki Nakashima, Sadayuki Ito, Jun Ouchida, Ryotaro Oishi, Ippei Yamauchi, Yuichi Miyairi, Yoshinori Morita, Mikito Tsushima, Hiroyuki Tomita, Kazuaki Morishita, Kazuma Ohshima, Tokumi Kanemura, Shiro Imagama

“…TBR, vertebral endplate cyst (VEC), facet union, and pseudarthrosis were investigated on computed tomography (CT) images at 3 months, 1 year, and 2 years postoperatively. Of the 53 patients, 36 (68%) who underwent CT examination at approximately 5 years postoperatively were subanalyzed. …”
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Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain by Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, Lin Zhang, Tony Gin, William K.K. Wu, Matthew T.V. Chan, Changyu Jiang, Xiaodong Liu

“…Chemotherapy-induced peripheral neuropathy (CIPN) and its related pain are common challenges for patients receiving oxaliplatin chemotherapy. Oxaliplatin accumulation in dorsal root ganglion (DRGs) is known to impair gene transcription by epigenetic dysregulation. …”
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Clinical outcomes of dogs with high-grade cutaneous mast cell tumors by Siew Mei Ong, Siew Mei Ong, Charly McKenna, Christopher Pinard, Christopher Pinard, Christopher Pinard, Christopher Pinard, Danielle Richardson, Michelle L. Oblak

“…The limited therapeutic benefit of locoregional lymph node extirpation, combined with a persistently high metastatic rate despite systemic chemotherapy, highlights the critical need for more effective regional and systemic treatment approaches for HGMCT patients.…”
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