Comparison of Fecal Calprotectin Methods for Predicting Relapse of Pediatric Inflammatory Bowel Disease by Saranya Kittanakom, Md. Sharif Shajib, Kristine Garvie, Joceline Turner, Dan Brooks, Sufian Odeh, Robert Issenman, V. Tony Chetty, Joseph Macri, Waliul I. Khan

“…This study used 40 pediatric IBD and 40 random non-IBD patients’ fecal samples. Two automated ELISAs (Bühlmann and PhiCal® Calprotectin-EIA) and an EliA (Phadia 250 EliA-Calprotectin) were used to evaluate the analytical performance. …”
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Use of virtual reality to remotely train healthcare professionals in paediatric emergency tracheostomy skills: protocol for a multi-centre, non-inferiority educational intervention... by Jonathan R. Abbas, Noorulanne Younis, Emily Johnstone, Azita Rajai, Rachel Isba, Antony Payton, Brendan A. McGrath, Neil Tolley, Iain A. Bruce

“…Abstract Background The insertion of a tracheostomy is an established technique used to wean patients off ventilatory support, manage secretions in complex conditions, and as a potentially life-saving procedure to bypass upper airway obstruction. …”
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Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Ci... by Alexander A. Pugovkin, Aleksandr G. Markov, Sergey V. Selishchev, Leonie Korn, Marian Walter, Steffen Leonhardt, Leo A. Bockeria, Olga L. Bockeria, Dmitry V. Telyshev

“…Furthermore, this study expands the information on LV-LVAD interaction, which leads to the optimization of the RBP speed rate control in clinics for adult and pediatric patients suffering from heart failure. Finally, we show that the implementation of control algorithms using the modulation of the RBP speed in order to open the aortic valve and unload the LV more efficiently is necessary and will be content of further research.…”
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Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria by Kim Anh Nguyen, Nasheeta Peer, Anniza de Villiers, Barbara Mukasa, Tandi E. Matsha, Edward J. Mills, Andre Pascal Kengne

“…A random sample included 748 HIV-infected adult patients (79% women) across 17 HIV healthcare facilities in the Western Cape Province. …”
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The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation by Lidia Karabon, Miroslaw Markiewicz, Karolina Chrobot, Monika Dzierzak-Mietla, Edyta Pawlak-Adamska, Anna Partyka, Anna Koclega, Slawomira Kyrcz-Krzemien, Irena Frydecka

“…Altogether, 295 adult patients (pts) undergoing related (105 pts) and unrelated (190 pts) donor-matched HSCT were genotyped for the following CD86 gene polymorphisms: rs1129055, rs9831894, and rs2715267. …”
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Personalized treatment strategies for breast adenoid cystic carcinoma: A machine learning approach by Sakhr Alshwayyat, Mahmoud Bashar Abu Al Hawa, Mustafa Alshwayyat, Tala Abdulsalam Alshwayyat, Siya sawan, Ghaith Heilat, Hanan M. Hammouri, Sara Mheid, Batool Al Shweiat, Hamdah Hanifa

“…Results: This study included 1212 patients. The median age was 60 years, with most tumors being localized and less than 2 cm in size. …”
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The Prevalence and Causes of Visual Impairment in Type 2 Diabetes Mellitus in Northeast China by Liang Wen, Yu Wang, Zhong Lin, Feng Hua Wang, Xiao Xia Ding, Dong Li, Kemi Feng, Yuan Bo Liang, Dong Xiao Zhang, Yu Dou, Gang Zhai

“…Population-based cross-sectional survey. Patients diagnosed with T2DM residing in 15 communities in Fushun, Northeast China, were enrolled between July 2012 and May 2013. …”
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Occupational violence toward mental health professionals during the COVID-19 pandemic: an international study by Rebeca Robles, Cary S. Kogan, María Elena Medina-Mora, María Elena Medina-Mora, José Ángel García-Pacheco, Tahilia J. Rebello, Brigitte Khoury, Maya Kulygina, Geoffrey M. Reed

“…Risk factors for any type/source of OV being younger, working in emergency services, treating COVID-19 patients, and living in a lower to upper middle-income country. …”
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Artificial intelligence assisted risk prediction in organ transplantation: a UK Live-Donor Kidney Transplant Outcome Prediction tool by Hatem Ali, Arun Shroff, Tibor Fülöp, Miklos Z. Molnar, Adnan Sharif, Bernard Burke, Sunil Shroff, David Briggs, Nithya Krishnan

“…Introduction: Predicting the outcome of a kidney transplant involving a living donor advances donor decision-making donors for clinicians and patients. However, the discriminative or calibration capacity of the currently employed models are limited. …”
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ENO1 promotes PDAC progression by inhibiting CD8+ T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling by Aziguli Tulamaiti, Shu-Yu Xiao, Yan Yang, Musitaba Mutailifu, Xia-Qing Li, Shi-Qi Yin, Hong-Tai Ma, Hong-Fei Yao, Lin-Li Yao, Li-Peng Hu, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Yan-Miao Huo, Dong-Xue Li, Xue-Li Zhang

“…Here, we investigated the role of ENO1 in modulating the PDAC microenvironment.Using bioinformatic analyses, we demonstrated that ENO1 was highly expressed in PDAC patients, which was related to a poor prognosis. In vitro, Eno1 knockdown resulted in reduced PDAC cell proliferation and colony formation, along with enhanced apoptosis in PDAC cells. …”
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Randomized Comparison of Terumo® Coated Slender™ versus Terumo® Noncoated Traditional Sheath during Radial Angiography or Percutaneous Coronary Intervention by Birthe Sindberg, Christel Gry Aagren Nielsen, Marianne Hestbjerg Poulsen, Martin Bøhme Rasmussen, Steen Carstensen, Troels Thim, Lars Jakobsen, Jacob Thorsted Sørensen, Benedicte Haastrup, Hanne Maare Søndergaard, Michael Mæng, Christian Juhl Terkelsen

“…Methods. A total of 1,000 patients scheduled for radial CAG or PCI were randomized (1:1) to the use of a Slender or a Standard sheath during the procedure. …”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…However, current treatments often show limited efficacy in certain patients and are associated with adverse effects, which highlights the need for safer and more effective therapeutic approaches. …”
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Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…Depending on timing, before hBM-MSC transplantation into patients, after detaching them from the culture dish, cell viability, deformability, cell size, and membrane fluidity are decreased, whereas reactive oxygen species generation, lipid peroxidation, and cytosolic vacuoles are increased. …”
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Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals by Bowen Zhu, Fang Li, Weidong Zhang, Shuan Zhao, Nana Song, Shi Jin, Ziyan Shen, Yufei Lu, Yang Li, Hong Liu

“…In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control.…”
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Infiltration and subtype analysis of CD3 + CD20 + T cells in lung cancer by Liping Luo, Juan Ji, Juan Dong, Maotao He, Wenjun Jiang, Yang Liu, Weidong Wang

“…They originate from T cells interacting with B cells, and their levels are abnormally elevated in individuals with immune disorders, as well as in some cancer patients. The interplay between tumor immunity and inflammation is intricate, yet the specific involvement of TB cells in local tumor immunity remains uncertain, with limited research on their subtypes. …”
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Clonal dissemination of an NDM-2-producing Acinetobacter baumannii ST103 clone resulting in an outbreak in an intensive care unit of a Lebanese tertiary care hospital by Tania Nawfal Dagher, Linda Hadjadj, Fadi Bittar, Fadi Fenianos, Elias Abdo, Jean-Marc Rolain, Charbel Al-Bayssari

“…Methods: Thirty-two non-duplicate CRAB isolates were collected from patients hospitalised in the ICU. Antibiotic susceptibility testing was carried out using the disk diffusion method and carbapenemase-encoding genes were searched for using standard polymerase chain reaction. …”
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Efficient Dual Cas9 Nickase Correction of a Prevalent Pathogenic LAMB3 Variant for Junctional Epidermolysis Bullosa by Alex du Rand, John Hunt, Daniel Verdon, Ben Buttle, P. Rod Dunbar, Diana Purvis, Vaughan Feisst, Hilary Sheppard

“…This protocol represents a significant improvement in precision gene repair using Cas9 nickases for epidermolysis bullosa, with the potential to be applied to a large cohort of patients harboring this prevalent pathogenic variant.…”
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Ten-Day versus 14-Day Levofloxacin-Containing Triple Therapy for Second-Line Anti-Helicobacter pylori Eradication in Taiwan by Wei-Chen Tai, Chien-Hua Chiu, Chih-Ming Liang, Kuo-Chin Chang, Chung-Mou Kuo, Yi-Chun Chiu, Keng-Liang Wu, Ming-Luen Hu, Yeh-Pin Chou, Shue-Shian Chiou, King-Wah Chiu, Chung-Huang Kuo, Tsung-Hui Hu, Ming-Tsung Lin, Seng-Kee Chuah

“…The current retrospective study aimed to clarify the effects of 10-day and 14-day levofloxacin-containing triple therapies for second-line H. pylori eradication in a Taiwanese cohort and to evaluate the potential clinical factors influencing eradication. A total of 200 patients who failed H. pylori eradication using the standard triple therapy were prescribed with either a 10-day (EAL-10) or a 14-day (EAL-14) levofloxacin-containing triple therapy group (levofloxacin 500 mg once daily, amoxicillin 1 g twice daily, and esomeprazole 40 mg twice daily). …”
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Bacterial blood microbiome of Mastomys rodents: implications for disease spill-over at the animal-human interface within the Bushbuckridge-East community, South Africa by Agatha O. Kolo, Agatha O. Kolo, Kelly A. Brayton, Kelly A. Brayton, Nicola E. Collins, Armanda D. S. Bastos, Armanda D. S. Bastos, Armanda D. S. Bastos, Sonja Matthee, Cory A. Gall, Jeanette Wentzel, Jeanette Wentzel, Luis Neves, Luis Neves, Marinda C. Oosthuizen

“…The detection of zoonotic agents in rodents in Bushbuckridge-East community, together with prior serological confirmation of Bartonella and Coxiella in non-malarial acute febrile patients from this community, highlights the possible risks that commensal rodents pose to human health.…”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer by Vrinda Sant, Dirk Matthes, Hisham Mazal, Leif Antonschmidt, Franz Wieser, Kumar T. Movellan, Kai Xue, Evgeny Nimerovsky, Marianna Stampolaki, Magdeline Nathan, Dietmar Riedel, Stefan Becker, Vahid Sandoghdar, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

“…This structural reconfiguration occurs in a conserved structural kernel shared by a vast number of αS-fibril polymorphs including extracted fibrils from Parkinson’s and Lewy Body Dementia patients. Consistent with reports of anti-parallel β-strands being a defining feature of toxic αS pre-fibrillar intermediates, I1 impacts viability of neuroblasts and disrupts cell membranes, resulting in an increased calcium influx. …”
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