Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials by Matt Vassar, Vinay Prasad, Ryan McIntire, Alyson Haslam, Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia

“…Trials for colorectal cancer started out as positive but became more negative over time. Cumulative risk to patients increased over time while ORR stayed consistently low.Conclusions Our findings suggest that since regorafenib’s original Food and Drug Administration (FDA) approval, the risk profile for its original indication increased. …”
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Patient Complications after Interscalene Block: A Retrospective Comparison of Liposomal Bupivacaine to Nonliposomal Bupivacaine by Jacob L. Hutchins, Jason Habeck, Zac Novaczyk, Richard Campbell, Christopher Creedon, Ellen Spartz, Michael Richter, Jeremy Wolter, Gaurav Suryawanshi, Alexander Kaizer, Aaron A. Berg

“…This was a single-center retrospective chart view performed by identifying patients who received an ISB from January 1, 2014, through April 26, 2018, at the University of Minnesota. 1,518 patients were identified who received an ISB (LB = 784, nonliposomal bupivacaine = 734). …”
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Erratum: Rumyantseva D.Ye. et al, “Intractable Hiccups in 64 Year-old Patient” by article Editorial

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Case report: Diagnosis of impaired consciousness in a cancer patient using immune checkpoint inhibitors by Daniel Cathalifaud, Daniel Cathalifaud, Cristóbal Basáez, Tatiana Yáñez, Tatiana Yáñez

“…We present the case of a patient diagnosed with pleural mesothelioma that started combined palliative immunotherapy two months before admission. …”
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Pembrolizumab for the Treatment of Locally Advanced Cutaneous Squamous Cell Carcinoma: Patient Selection and Special Considerations by Stewart M, Geiger JL

“…With many patients achieving a complete response, immunotherapy presents a promising option; however, ongoing research is needed to refine its use, especially in immunocompromised or high-risk patients.Keywords: cutaneous squamous cell carcinoma, cSCC, immunotherapy, pembrolizumab…”
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Rare Presentation of Schizophrenia in a Patient with Congenital Right Lung Agenesis: A Case Report by Mamidipalli Sai Spoorthy, Sai Krishna Tikka, Barikar C. Malathesh, Syed Ahmed Zaki

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Acute Coronary Syndrome (ACS) due to Coronary Artery Embolism in a Patient with Atrial Fibrillation by Hussein Daoud, Ashraf Abugroun, Shruti Erramilli, Surender Kumar

“…A coronary angiogram was significant for three focal transluminal and translucent areas in the ostial, mid, and distal circumflex artery consistent with embolic disease. The patient was subsequently managed medically with anticoagulation. …”
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A Rare Case of Stroke Secondary to Iron Deficiency Anemia in a Young Female Patient by Kavitha Gopalratnam, Kevin Andrew Woodson, Jigarkumar Rangunwala, Kanaga Sena, Manisha Gupta

“…Most stroke cases are seen in patients over 65 years of age. However, about one-fourth of strokes occur in young adults. …”
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Continuous Erector Spinae Plane Block for Analgesia after Thoracotomy for Lung Transplantation in an Anticoagulated Patient by Mark Mudarth, Veena Satyapriya, John Coffman, Peter DeSocio, Alec Lawrence, Shana Schwartz, Michael Kushelev

“…The ESP block was effective in this case and thus may be a valuable alternative following lung transplantation for patients who are not candidates for thoracic epidural or paravertebral approaches.…”
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Identification of novel RIPK4 variants in a Chinese patient with Arthrogryposis Multiplex Congenita (AMC) by Yi-Lei Lu, Meng-wei Liu, Jie-Yuan Jin, Ding Pan

“…Methods We recruited a Chinese female patient with hand-related AMC and her family members. …”
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Extracorporeal Cardiopulmonary Resuscitation for Management of Out-of-Hospital Cardiac Arrest in a Patient with Fulminant Myocarditis by Alexander J. Meyer, Michael A. Biersmith, Ernest L. Mazzaferri, Konstantinos Dean Boudoulas

“…A 68-year-old male with a witnessed out-of-hospital cardiac arrest while jogging who was managed with extracorporeal cardiopulmonary resuscitation (ECPR) is presented. The patient was found to be in refractory ventricular fibrillation by emergency medical service personnel and underwent advanced cardiac life support (ACLS) protocol with placement of an automated chest compression device. …”
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Cerebral Phaeohyphomycosis in a Patient with Neurosarcoidosis on Chronic Steroid Therapy Secondary to Recreational Marijuana Usage by Preetam Gongidi, Debkumar Sarkar, Eric Behling, Joshua Brody

“…Cerebral phaeohyphomycosis is often a fatal disease that typically takes a hematogenous spread after inhalation or accidental skin inoculation of pathogens. We present a patient with a history of heavy marijuana smoking while being on chronic steroid therapy for treatment of neurosarcoidosis who was found to have multiple brain abscesses from Curvularia sp. …”
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A Case of Physically Abused OCD Patient Who Physically Abused Her own Child by Tuğba AYAZ, Ayşe Gül YILMAZ ÖZPOLAT, Damla YÜCEL, Umut ALTUNÖZ

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Community advisory boards as implementation strategies to center partner and patient voice in community health centers by Rebekka M. Lee, Kamini Mallick, James G. Daly, Vetta Sanders Thompson, Elise Hoffman, Maria Papadopoulos, Stacey Curry

“… Abstract Introduction: Community advisory boards (CABs) are a promising approach for strengthening patient and partner voices in community health center (CHC) evidence-based decision-making. …”
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Mucinous Cystadenoma Arising in a Mature Cystic Teratoma in a 25-Year-Old Patient by Michelle D. Pintea

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When can cancer patient treatment nonadherence be considered intentional or unintentional? A scoping review. by Leon Wreyford, Raj Gururajan, Xujuan Zhou

“…<h4>Background</h4>Treatment nonadherence in cancer patients remains high with most interventions having had limited success. …”
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Amyloid Accumulation in the Toxic Nodule of the Thyroid Gland in a Patient with End Stage Renal Failure by Umut Mousa, Sema Aktas, Halit Uner

“…Most of the cases reported up to now were clinically euthyroid, but many presentation forms and overlaps have been reported. Herein we present a patient with toxic nodular goiter with amyloid deposition in the toxic nodule as well as the remaining thyroid tissue.…”
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Open-Label Fosmetpantotenate, a Phosphopantothenate Replacement Therapy in a Single Patient with Atypical PKAN by Yiolanda-Panayiota Christou, George A. Tanteles, Elena Kkolou, Annita Ormiston, Kostas Konstantopoulos, Maria Beconi, Randall D. Marshall, Horacio Plotkin, Kleopas A. Kleopa

“…Fosmetpantotenate showed promising results in a single PKAN patient and should be further studied in controlled trials.…”
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Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient by Shinsaku Imashuku, Miyako Kobayashi, Yoichi Nishii, Keisuke Nishimura

“…It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. …”
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Laparoscopic Sleeve Gastrectomy in a Morbidly Obese Patient with Myasthenia Gravis: A Review of the Management by Megana Ballal, Tracey Straker

“…Therefore, we can minimize perioperative risks and complications by adjusting the anesthetic plan based on the patient’s physiology and comorbidities as well as the pharmacology of the drugs.…”
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