Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome by Turgay Ucak, Ethem Unver

“…Decreased vascular structures and increased FAZ may also be associated with the disease severity in OSAS and may be the main pathophysiological mechanisms in ocular alterations, which should be investigated in further studies.…”
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Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia by Satoshi Morimoto, Haruki Sasaki, Chikahito Suda, Atsuhiro Ichihara, Nobuyuki Ura

“…The (pro)renin receptor ((P)RR) is a multifaceted protein with both pathophysiological and physiological functions. (P)RR is cleaved to generate soluble (P)RR, whose blood concentration may reflect the expression level of tissue (P)RR. …”
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Epigenetic regulation of the inflammatory response in stroke by Jingyi Liang, Fei Yang, Zixiao Li, Qian Li

“…This may be attributable to the dichotomous roles of inflammation in both tissue injury and repair, as well as the complex pathophysiologic inflammatory processes in stroke. Inhibiting acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic strategies. …”
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Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review. by Kerry McInnes, Christopher L Friesen, Diane E MacKenzie, David A Westwood, Shaun G Boe

“…The number of individuals who experience persistent symptoms appears to be low despite clear evidence of longer-term pathophysiological changes resulting from mTBI. In light of the incongruency between these longer-term changes in brain pathology and the number of individuals with longer-term mTBI-related symptoms, particularly impaired cognitive function, we performed a scoping review of the literature that behaviourally assessed short- and long-term cognitive function in individuals with a single mTBI, with the goal of identifying the impact of a single concussion on cognitive function in the chronic stage post-injury. …”
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Venipuncture-Induced Complex Regional Pain Syndrome: A Case Report and Review of the Literature by Foad Elahi, Chandan G. Reddy

“…The inciting incident in complex regional pain syndrome (CRPS) can often seem far too trivial to result in a condition with such severe pathophysiologic effects. The practicing physician has little information available to enable early recognition of the condition, initiation of multidisciplinary treatment modalities, and proper referral to pain specialists. …”
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Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus by Le Dai, Qing Wang

“…Transplanted MSCs are also extremely susceptible to perturbations in their microenvironment, especially OS, which can weaken their antioxidant capacity and induce MSCs death through ferroptosis. In the pathophysiological process of T1DM, a large amount of reactive oxygen species (ROS) are produced, causing OS. …”
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Gastroesophageal Reflux Disease and Coronary Heart Disease: Is There a “Mutual Burden” Syndrome? by O. P. Alekseeva, D. V. Pikulev

“…In addition to common risk factors, a number of pathophysiological mechanisms have been established that determine a pathogenetic relationship between CHD and GERD. …”
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Characterization of Intussusception in Qena University Hospital by Eman Saber Ahmed, Nezar Abdelraouf Abo Halawa, Mahmoud Abdelhamid, Mohammed Ahmed Negm

“…Our results emphasize the significance of rapid detection and therapy of intussusception in pediatric patients, particularly those with comorbidities. Explore the pathophysiological causes and risk factors of intussusception in children to guide preventive and early intervention techniques.…”
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Liver Fibrosis and Altered Matrix Synthesis by Katrin Neubauer, Bernhard Saile, Giuliano Ramadori

“…The hepatic stellate cells seem to be the primary target cells for these inflammatory stimuli, because during fibrogenesis, they undergo an activation process to a myofibroblast-like cell, which represents the major matrix-producing cell. Based on this pathophysiological mechanism, therapeutic methods are developed to inhibit matrix synthesis or stimulate matrix degradation. …”
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UNLOCKING THE MIND-BODY CONNECTION: BRUXISM VERSUS PSYCHOLOGICAL FACTORS by Mirela Ioana Fluerasu, Ioana Corina Bocsan, Smaranda Buduru, Simona Maria Iacob, Andrea Maria Chisnoiu, Andra Nichimis, Antonela Berar, Marius Negucioiu, Daniela Popa

“…This proved once more that the two clinical forms of bruxism were different pathophysiological entities requiring a specific, individualized approach.…”
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Nanomaterials: Promising Tools for the Diagnosis and Treatment of Myocardial Infarction by Ge Y, Wu L, Mei S, Wu J

“…We summarize the pathophysiological mechanisms and staging of myocardial infarction. …”
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Deciphering Metabolic Responses in Traumatic Brain Injury Patients With Different Severity Using 1H NMR-Based Serum Metabolomics by Huan Zhou, Dongdong Sun, Dongmei Wang, Zirui Zhu, Xuelian Hong, Rui Fang, Hua Wang, Minghui Li

“…In order to elucidate the underlying pathophysiologic mechanisms and identify serum biomarkers associated with TBI, we conducted a comprehensive investigation utilizing a 1H nuclear magnetic resonance (NMR)–based metabolomics approach and ELISA analysis of serum samples obtained within 24 h postinjury from a cohort of participants with varying degrees of TBI severity. …”
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Regulation of (Pro)Renin Receptor in Renin-Positive Smooth Muscle Cells of Kidney Arterioles in Rats with STZ-Induced Diabetes by Zsolt Razga, Gabor Kovacs, Nikolett Bódi, Petra Talapka, Mária Bagyánszki

“…The nephron (pro)renin receptor may play a pathophysiological role in renal disorders in hypertension or diabetes. …”
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Sequential exploratory mixed-method research of an eHealth intervention on blood pressure, sleep quality and physical activity in obstructive sleep apnoea: rationale and methodolog... by Manuel Sánchez-de-la-Torre, Ferran Barbé, Oriol Martínez-Navarro, Francisco José Verdejo-Amengual, Fran Valenzuela-Pascual, Joan Blanco-Blanco, Rabie Adel El Arab, Esther Rubinat-Arnaldo, Maria Masbernat-Almenara, Francesc Rubí‑Carnacea, Blanca Manuel Martí

“…This study will evaluate the effectiveness of an eHealth tool in managing the pathophysiological consequences of OSA and how they impact the quality of life after 3 months of intervention among adults.Methods and analysis This is a mixed-method sequential exploratory study protocol. …”
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Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study by Huaying Cai, Zhiyong Zhao, Linhui Ni, Guocan Han, Xingyue Hu, Dan Wu, Xianjun Ding, Jin Wang

“…Our findings suggest that PSD patients show dementia-specific structural and functional alteration patterns, which may help elucidate the pathophysiological mechanisms underlying PSD.…”
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Invasive Treatment of Lower Limb Varicose Veins - Comparison of Treatment Methods by Ewa Piekarska, Krzysztof Dobrzeniecki, Remigiusz Luter

“…Summary: Despite the high prevalence and complex pathophysiological mechanisms of varicose veins in the lower extremities, current treatment methods allow for a satisfactory therapeutic outcome in most patients. …”
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Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure by Patrick Geraghty, Nathalie Baumlin, Matthias A. Salathe, Robert F. Foronjy, Jeanine M. D’Armiento

“…Therefore, ER stress may be an antioxidant-related pathophysiological event in COPD.…”
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The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review by Huang Jiecheng, Fan Yuxuan, Wang Yongshun, Liu Jingjin

“…This review provides an overview of the current literature on the pathophysiological pathways linking coronavirus disease 2019 to anxiety, as well as the possible mechanisms of action in which an increasingly scrutinized treatment method, enhanced external counter-pulsation (EECP), is able to alleviate anxiety. …”
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Identification of molecular characteristics in polycystic ovary syndrome using single-cell and transcriptome analysis by Xiaolin Zhu, Yanhua Han, Yuenan Feng, Yuanli Shan, Chang Liu, Kexin Wang, Xiaoke Li, Shidi Zhang, Yaguang Han

“…Our study, by analyzing multiple datasets, has revealed the complex molecular network of PCOS, offering new insights into understanding its pathophysiological basis.…”
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Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection by Marcos Daniel Mendes Padilha, Francisco Tiago de Vasconcelos Melo, Rogério Valois Laurentino, Andrea Nazaré Monteiro Rangel da Silva, Rosimar Neris Martins Feitosa

“…In view of the above, this review aimed to correlate the pathophysiological mechanisms in HBV and HCV infection, the dysregulation of the microbiome in patients infected with HBV and HCV, the most altered cytokines in the microbiome, and the most altered bacterial representatives in the pathobiome of infection.…”
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