Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia by A. Hichami, O. Grissa, I. Mrizak, C. Benammar, N. A. Khan

“…In this paper, we shed light on the role of T-cell malfunction that leads to an inflammatory and pathophysiological state, related to insulin resistance in GDM and macrosomia. …”
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Management recommendations to reduce cardiac risk in chronic epilepsy by Trudy D. Pang, Richard L. Verrier, Steven C. Schachter

“…Multifactorial lines of evidence in adults point to a critical linkage between chronic epilepsy and elevated risk for cardiovascular disease and premature cardiac death. Diverse pathophysiological processes appear to be involved that include accelerated atherosclerosis, myocardial infarction, abnormal autonomic tone, heart failure, atrial and ventricular arrhythmias, and hyperlipidemia. …”
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Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. …”
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Transition from Hepatopulmonary Syndrome to Portopulmonary Hypertension: A Case Series of 3 Patients by Radhika Zopey, Irawan Susanto, Igor Barjaktarevic, Tisha Wang

“…Given these seemingly opposing pathophysiologic mechanisms, these conditions were traditionally felt to be mutually exclusive. …”
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Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer’s disease pathology by Maxime Van Egroo, Elise Beckers, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Heidi I. L. Jacobs

“…Here, we examined sex-specific associations between circadian rest-activity patterns and AD-related pathophysiological processes across the adult lifespan. …”
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Nanomaterials for targeted therapy of kidney diseases: Strategies and advances by Zhiwen Wang, Chun Zhang

“…Rationally designing and modifying nanomaterials based on the anatomical structure and pathophysiological environment of the kidney to achieve highly specific kidney-targeted nanomaterials or nanodrug delivery systems is both feasible and promising. …”
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Cognitive Impairments in Viral Hepatitis Patients: Causes, Manifestations, and Impact on Quality of Life by Tatyana Vasiliyevna Polukchi

“…Key areas covered include the pathophysiological mechanisms behind cognitive impairment in viral hepatitis, clinical manifestations observed in affected patients, the implications for their daily functioning and overall well-being, and the tools used in cognitive assessments. …”
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Understanding Muscle Dysfunction in Chronic Fatigue Syndrome by Gina Rutherford, Philip Manning, Julia L. Newton

“…Historically, there has been a tendency to draw psychological explanations for the origin of fatigue; however, this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial, and neuronal pathways. …”
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Prostanoid Receptors in the Human Vascular Wall by Xavier Norel

“…There is an accumulation of evidence for the involvement of prostanoids, the arachidonic acid metabolites derived from the cyclooxygenase enzymatic pathway, in physiological and/or pathophysiological conditions. In humans, the prostanoids activate different receptors. …”
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Bariatric Surgery, Polycystic Ovary Syndrome, and Infertility by James Butterworth, Jean Deguara, Cynthia-Michelle Borg

“…Visceral obesity and insulin resistance are key pathophysiological mechanisms behind PCOS. Women suffering from this syndrome and infertility often seek bariatric surgery hoping that they would be able to conceive postoperatively. …”
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Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns by Maria Portelli, Byron Baron

“…So far, a number of biomarkers have been proposed for predicting PE, based on pathophysiological observations, but these have mostly proven to be unreliable and inconsistent between different studies. …”
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A Novel Method of Imaging Lysosomes in Living Human Mammary Epithelial Cells by Kristine Glunde, Sandra E. Guggino, Yoshitaka Ichikawa, Zaver M. Bhujwalla

“…The ability to noninvasively label lysosomes and track lysosomal trafficking would be extremely useful to understand the mechanisms by which degradative enzymes are secreted in the presence of pathophysiological environments, such as hypoxia and acidic extracellular pH, which are frequently encountered in solid tumors. …”
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Hypothesis: glyphosate-based herbicides can increase risk of hematopoietic malignancies through extended persistence in bone by Charles M. Benbrook

“…The hypothesis proposed here provides a plausible pathophysiologic basis for these observations relative, in particular, to blood cancers.…”
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Pediatric Functional Constipation: A New Challenge by Samina Khan Bashir, Muhammad Bashir Khan

“…Multiple complex pathophysiological mechanisms have been linked to childhood constipation, in which stool-withholding behavior is the most common factor. …”
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Evolving perspectives on aortic stenosis: the increasing importance of evaluating the right ventricle before aortic valve intervention by Vitaliy Androshchuk, Omar Chehab, Joshua Wilcox, Benedict McDonaugh, Natalie Montarello, Ronak Rajani, Bernard Prendergast, Tiffany Patterson, Simon Redwood

“…Aortic stenosis (AS) was historically considered a disease of the left side of the heart, with the main pathophysiological impact being predominantly on the left ventricle (LV). …”
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Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications by Meng Cai, Gopi K. Kolluru, Asif Ahmed

“…To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions. In contrast, the study of microRNA in pregnancy and its associated complications, such as preeclampsia (PE), fetal growth restriction (FGR), and preterm labor, is a young field. …”
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An Emerging Role of Glucagon-Like Peptide-1 in Preventing Advanced-Glycation-End-Product-Mediated Damages in Diabetes by Alessandra Puddu, François Mach, Alessio Nencioni, Giorgio Luciano Viviani, Fabrizio Montecucco

“…Since chronic hyperglycemia contributed to the acceleration of the formation of Advanced Glycation End-Products (AGEs, a heterogeneous group of compounds derived from the nonenzymatic reaction of reducing sugars with free amino groups of proteins implicated in vascular diabetic complications), the administration of GLP-1 might directly counteract diabetes pathophysiological processes (such as pancreatic β-cell dysfunction). …”
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Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine by Jiming Guo, Zhijie Huang, Qinjing Wang, Min Wang, Yue Ming, Weixing Chen, Yisheng Huang, Zhengming Tang, Mingshu Huang, Hongyu Liu, Bo Jia

“…This review provides a description of the biogenesis and pathophysiological functions of BEVs, and strategies for optimizing BEVs preparation to attain efficiency and safety are discussed. …”
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Subjective Visual Vertical in PD Patients with Lateral Trunk Flexion by F. Gandor, D. Basta, D. Gruber, W. Poewe, G. Ebersbach

“…In a subgroup of PD patients with LTF, pathological SVV suggests vestibular dysbalance, which might be involved in the pathophysiological mechanisms underlying LTF.…”
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Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining by Ji Eun Lim, Kyung-Won Hong, Hyun-Seok Jin, Bermseok Oh

“…In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. …”
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