Recurrence of acne after treatment with systemic isotretinoin: causes and methods of prevention by Marina M. Tlish, Marina E. Shavilova

“…Despite this, the multifactorial etiology and complex pathophysiological processes of acne development determine the risk of relapse of the disease. …”
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A human oral commensal-mediated protection against Sjögren’s syndrome with maintenance of T cell immune homeostasis and improved oral microbiota by Yu-Chao Tseng, Kai-Sheng Liao, Wei-ting Lin, Chin Li, Chia-Bin Chang, Jie-Wei Hsu, Chin-Pui Chan, Chun-Ming Chen, Hon-Pin Wang, Hsiu-Chuan Chien, Jann-Tay Wang, Song-Chou Hsieh, Shu-Fen Wu

“…This study aimed to elucidate the pathophysiological role of H. parainfluenzae in SS. Reduced salivary H. parainfluenzae levels in SS patients were confirmed through quantitative PCR. …”
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Brain Connectivity Plasticity in the Motor Network after Ischemic Stroke by Lin Jiang, Huijuan Xu, Chunshui Yu

“…We suggest that connectivity changes constitute an important pathophysiological aspect of motor impairment after stroke and important mechanisms of motor recovery. …”
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Climate change, air pollution and chronic respiratory diseases: understanding risk factors and the need for adaptive strategies by Jiayu Xu, Zekang Su, Chenchen Liu, Yuxuan Nie, Liangliang Cui

“…Furthermore, this association can be modified by factors such as socioeconomic status, adaptability, individual behavior, medical services. Potential pathophysiological mechanisms linking climate change and increased risk of CRD involved pulmonary inflammation, immune disorders, oxidative stress. …”
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Aldosterone and Its Blockade: A Cardiovascular and Renal Perspective by V. Lahera, V. Cachofeiro, G. Balfagon, J.L. Rodicio

“…It is important to mention that dietary salt is a key factor in aldosterone-mediated cardiovascular damage, since damage was moreevident in animals on a high-salt diet than animals on a low salt diet. A pathophysiological action of aldosterone involves development of extracellular matrix and fibrosis, inflammation, stimulation of reactive oxygen species production, endothelial dysfunction, cell growth and proliferation. …”
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TNM-Like Classification: A New Proposed Method for Heart Failure Staging by Francesco Fedele, Maria Chiara Gatto, Alessandra D’Ambrosi, Massimo Mancone

“…For all these reasons, it is our intention to propose a valid and more specific classification available for the clinical staging of HF that takes into account pathophysiological and structural changes that can remark prognosis and management of HF.…”
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Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications by Ibrahim Luru Abdulai, Samuel Kojo Kwofie, Winfred Seth Gbewonyo, Daniel Boison, Joshua Buer Puplampu, Michael Buenor Adinortey

“…Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. …”
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The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function by Jana Štikarová, Roman Kotlín, Tomáš Riedel, Jiří Suttnar, Kristýna Pimková, Leona Chrastinová, Jan E. Dyr

“…It has been suggested that modification of fibrinogen may cause thrombotic/bleeding complications associated with many pathophysiological states of organism. We exposed fibrinogen molecules to three different modification reagents—malondialdehyde, sodium hypochlorite, and peroxynitrite—that are presented to various degrees in different stages of oxidative stress. …”
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Valvular Cardiomyopathy: The Value of Cardiovascular Magnetic Resonance Imaging by Vasiliki Tsampasian, Sandeep S. Hothi, Thuwarahan Ravindrarajah, Andrew J. Swift, Pankaj Garg, Vassilios S. Vassiliou

“…Cardiovascular magnetic resonance (CMR) imaging has had a vast impact on the understanding of a wide range of disease processes and pathophysiological mechanisms. More recently, it has contributed significantly to the diagnosis and risk stratification of patients with valvular heart disease. …”
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Febrile Seizures and Febrile Seizure Syndromes: An Updated Overview of Old and Current Knowledge by Abdulhafeez M. Khair, Dalal Elmagrabi

“…Their etiology and pathophysiological pathways are being understood better over time; however, there is still more to learn. …”
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Small-Molecule Hormones: Molecular Mechanisms of Action by Monika Puzianowska-Kuznicka, Eliza Pawlik-Pachucka, Magdalena Owczarz, Monika Budzińska, Jacek Polosak

“…Nuclear hormone receptors interact with coactivators, corepressors, basal transcription factors, and other transcription factors in order to modulate the activity of target genes in a manner that is dependent on tissue, age and developmental and pathophysiological states. The biological effect of this mechanism becomes apparent not earlier than 30–60 minutes after hormonal stimulus. …”
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Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA by Stephanie He, Davindra Singh, Brandon Helfield

“…These findings underscore the critical role microbubble flow rate plays in focused ultrasound gene therapy, especially notable for applications in which blood velocity itself is a salient pathophysiological indicator of disease progression, including ischemia.…”
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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson’s disease pathology by Alise Zagare, Janis Kurlovics, Catarina Almeida, Daniele Ferrante, Daniela Frangenberg, Armelle Vitali, Gemma Gomez-Giro, Christian Jäger, Paul Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Egils Stalidzans, Giuseppe Arena, Jens C Schwamborn

“…Studies show that insulin resistance, which is the driving pathophysiological mechanism of T2D plays a major role in neurodegeneration by impairing neuronal functionality, metabolism and survival. …”
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Connection between oral health and chronic diseases by Di Fu, Xingyue Shu, Ge Zhou, Mengzhen Ji, Ga Liao, Ling Zou

“…Additionally, novel insights into the underlying pathophysiological mechanisms governing these relationships are presented. …”
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Enhanced proteomic profiling of human plasma‐derived extracellular vesicles through charge‐based fractionation to advance biomarker discovery potential by Xianyi Su, Getúlio Pereira de Oliveira Júnior, Anne‐Lise Marie, Michal Gregus, Amanda Figueroa‐Navedo, Ionita C. Ghiran, Alexander R. Ivanov

“…Abstract The study introduces a charge‐based fractionation method for fractionating plasma‐derived extracellular vesicles (EVs) into sub‐populations aimed at the improved purification from free plasma proteins to enhance the diagnostic potential of EV sub‐populations for specific pathophysiological states. Here, we present a novel approach for EV fractionation that leverages EVs’ inherent surface charges, differentiating them from other plasma components and, thus, reducing the sample complexity and increasing the purity of EVs. …”
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Time-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures by Dandan Cao, Yijun Liu, Yanfei Cheng, Jue Wang, Bolun Zhang, Yanhui Zhai, Kongfu Zhu, Ye Liu, Ye Shang, Xiao Xiao, Yi Chang, Yin Lau Lee, William Shu Biu Yeung, Yuanhua Huang, Yuanqing Yao

“…The holistic characterization of the physiological and pathophysiological window of implantation and a computational tool trained on this temporal atlas provide a platform for future therapeutic developments.…”
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Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury by Pascal Rowart, Pauline Erpicum, Olivier Detry, Laurent Weekers, Céline Grégoire, Chantal Lechanteur, Alexandra Briquet, Yves Beguin, Jean-Marie Krzesinski, François Jouret

“…Particularly, the duration of blood supply deprivation has been recognized as a critical factor in stroke, hemorrhagic shock, or myocardial infarction, as well as in solid organ transplantation (SOT). Pathophysiologically, IRI causes multiple cellular and tissular metabolic and architectural changes. …”
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PAI-1: An Integrator of Cell Signaling and Migration by Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins

“…., vitronectin), the low-density lipoprotein receptor-related protein-1 (LRP1), and the uPA/uPA receptor complex have dramatic consequences on the migratory phenotype and may underlie the pathophysiologic sequalae of PAI-1 deficiency and overexpression. …”
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Adipokines regulate the development and progression of MASLD through organellar oxidative stress by Ke Zhao, Heng Zhang, Wenyu Ding, Xiaoshuai Yu, Yanli Hou, Xihong Liu, Xinhua Li, Xiaolei Wang

“…The prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD), which is increasingly being recognized as a leading cause of chronic liver pathology globally, is increasing. The pathophysiological underpinnings of its progression, which is currently under active investigation, involve oxidative stress. …”
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Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseas... by Lindner Ewald, Langner-Wegscheider Beate, Sarny Stephanie, Renner Wilfried, El-Shabrawi Yosuf

“…Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.…”
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