Dietary peptides in aging: Evidence and prospects by Khushwant S. Bhullar, Jianping Wu

“…Modulation of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related pathophysiologies. Food derived bioactive peptides are characterized modulators of these pathways, while some verified in vivo and even clinically approved, and numerous others are under development. …”
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Spontaneous Type 2 Diabetic Rodent Models by Yang-wei Wang, Guang-dong Sun, Jing Sun, Shu-jun Liu, Ji Wang, Xiao-hong Xu, Li-ning Miao

“…Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. …”
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The Pharmacotherapy of Chronic Pain: A Review by Mary E Lynch, C Peter N Watson

“…The past two decades have contributed a large body of preclinical work that has assisted in our understanding of the underlying pathophysiological mechanisms that cause chronic pain. In this context, it has been recognized that effective treatment of pain is a priority and that treatment often involves the use of one or a combination of agents with analgesic action. …”
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Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome by Jibin Han, Yanmin Li, Yuanyuan Li

“…MSC-based therapies have the advantage of targeting nearly all pathophysiological components of ARDS by means of a variety of secreted trophic factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. …”
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Whipple’s Disease-Associated Pulmonary Hypertension with Positive Vasodilator Response Despite Severe Hemodynamic Derangements by Salah Najm, Joud Hajjar, Robert P Nelson, Ramana S Moorthy, Karen M Wolf, Tim Lahm

“…Pulmonary hypertension (PH) associated with Whipple’s disease (WD-PH) is extremely rare, and the underlying pathophysiological processes are incompletely understood. …”
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Bladder Leiomyoma with Synchronous Solitary Fibrous Tumor of the Pleura by Charalampos Mavridis, George Georgiadis, Eleni D. Lagoudaki, Iordanis Skamagkas, Ioannis Heretis, Anastasios V. Koutsopoulos, Charalampos Mamoulakis

“…Bladder leiomyomas (BLs) are extremely rare benign tumors of mesenchymal origin. The exact pathophysiological mechanisms that lead to their appearance remain unclear including hormonal disorders, chromosomal abnormalities, and fetal remnants in the bladder. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…Herein, we summarized the impairment of glucose metabolism and its pathophysiological mechanisms in patients with MDD. In addition, we briefly discussed potential pharmacological interventions for glucose metabolism to alleviate MDD, including glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, and pioglitazone, to encourage the development of new therapeutics.…”
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Retroodontoid Pseudotumor Related to Development of Myelopathy Secondary to Atlantoaxial Instability on Os Odontoideum by M. Hamard, S. P. Martin, S. Boudabbous

“…Less frequently, ROP formation can develop with other noninflammatory entities, with atlantoaxial instability as most accepted pathophysiological mechanism for posttraumatic or degenerative ROP. …”
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Liposomal Antioxidants for Protection against Oxidant-Induced Damage by Zacharias E. Suntres

“…Reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide, and hydroxyl radical, can be formed as normal products of aerobic metabolism and can be produced at elevated rates under pathophysiological conditions. Overproduction and/or insufficient removal of ROS result in significant damage to cell structure and functions. …”
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Intraoperative Cardiac Complications in Liver Transplantation: Preoperative Evaluation – A Narrative Review by Nedim Çekmen, Ahmed Uslu

“…Cardiac actions are the most essential cause of mortality during LT and have a significant impact on overall outcomes. The pathophysiological effects of ESLD on the circulatory system cause critical difficulties in perioperative treatment. …”
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A Rare Case of Adolescent Girl with Beard-PCOS with a Difference: “HAIR-AN Syndrome” by Payal S. Kubsad, Vani Hebbal Nagarajappa, Dhanya Soodhana Mohan

“…HAIR-AN syndrome being a specific subtype of PCOS consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN) with adipose tissue dysfunction as the initial pathophysiological stimulant. We report a 16-year-old developmentally normal adolescent girl with excessive facial hair growth, an irregular menstrual cycle, and hyperpigmentation who attained menarche at the age of 12. …”
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Primary Cardiac Lymphoma Presenting with Thrombocytopenia, Right Heart Failure, and Cardiogenic Shock by Samantha Kurniawan, Gita Mathur, Yvonne Bogun, Giselle Kidson-Gerber

“…This case also elucidates a potential pathophysiological association between PCL and thrombocytopenia.…”
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Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials by Ronaldo Paolo Panganiban, Christina McAninch, Marina Chulkina, Irina V. Pinchuk

“…We highlight evidence implicating telocytes in the pathogenesis of IBD and other chronic inflammatory diseases that share similar pathophysiological processes with IBD. Lastly, we discuss the current challenges in gut telocyte biology and the potential therapeutic implications of telocytes in IBD.…”
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Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model by Ibrahim Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…Background. Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases. …”
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Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation by Gaia Favero, Lorenzo Franceschetti, Francesca Bonomini, Luigi Fabrizio Rodella, Rita Rezzani

“…Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome.…”
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Jehovah’s Witness Needing Critical Care: A Narrative Review on the Expanding Arsenal by Ryan Davids, Gareth Robinson, Charmé Van Tonder, Jordan Robinson, Nadiyah Ahmed, Abdurragmaan Domingo

“…The review to follow explores the physiological and pathophysiological consequences of severe anaemia. Non-blood transfusion practices are explored, many of which are potentially lifesaving. …”
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Exploring the Ancient Persian/Unani Theory of Connection between Gastrointestinal and Respiratory Tracts: Current Evidence and Future Directions by Shahin Saeidinejat, Syed Mohd Abbas Zaidi, Alireza Ranjbar, Alireza Derakhshan

“…Numerous epidemiologic, pathophysiologic and clinical evidence confirm the interrelationship and integrated functioning of the respiratory and gastrointestinal tracts. …”
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Proliferative Vitreoretinopathy after Eye Injuries: An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid by Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Mario R. Romano, Ciro Costagliola, Francesco Semeraro

“…Knowledge of the pathobiological and pathophysiological mechanisms involved in posttraumatic PVR is increasing the possibilities of management, and it is hoped that in the future our treatment strategies will evolve, in particular adopting a multidrug approach, and become even more effective in vision recovery. …”
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The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective by Sheng Chen, Min Wang, Shuai Zhang, Xin Huang, Xinke Sui, Dou Li, Changqing Zhong, Wei Wu

“…Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. …”
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Reversible Inferolateral ST-Segment Elevation Associated with Small Bowel Obstruction by Ankit Upadhyay, Sudheer Chauhan, Umair Jangda, Vipul Bodar, Ahmed Al-Chalabi

“…In addition, prompt resolution of ST-segment elevation was seen after surgical treatment. The pathophysiological etiology of electrocardiographic changes accompanying small bowel obstruction is yet to be explored.…”
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