Short Bowel Syndrome: Surgical Therapy by W Donald Buie, Olin G Thurston, Richard N Fedorak

“…Most forms of surgical therapy are supportive and aim at controlling three basic pathophysiological defects: decreased intestinal transit time, gastric hypersecretion, and reduced functional mucosal surface area. …”
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Drug-induced lupus by Kavadichanda Chengappa G

“…Numerous drugs ranging from the classically described procainamide and hydralazine to novel biological agents such as anti-tumor necrosis factors and immune checkpoint inhibitors are implicated in causing DILE. Various pathophysiologic mechanisms such as decreased central tolerance, molecular cross-reactivity, and epigenetic modifications of immune cells are known to play a role in the precipitation of drug-induced autoimmunity. …”
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Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance by Zhou Qiyuan, Li Jingyan, Tian Yingping, Yao Yongming

“…The interaction between these factors is further examined for its significance in the pathophysiological processes of sepsis and related complications. …”
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Nitric oxide as a mediator of inflammation?—You had better believe it by Mark J. S. Miller, Matthew B. Grisham

“…In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). …”
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Infection <i>Helicobacter pylori</i> and stomach cancer: state-of-the-art by A. A. Sheptulin

“…Nowadays it is indicated for patients with high risk of SC (having atrophic gastritis, postgastrectomy patients for early SC, first-degree relatives of patients with SC).Conclusion. Pathophysiological and clinical aspects of interrelations between Н. pylori infection and SC require the further studies.…”
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A Quarter Century of Liver Transplantation: Learning from Livers by Paul C. Adams

“…Liver transplantation has emerged as a powerful tool to increase the understanding of physiological and pathophysiological processes in the liver. Transplantation for metabolic diseases with resolution of the disease process has been the ultimate proof of the hepatic source of the defect. …”
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Another Report of Acalculous Cholecystitis in a Greek Patient with Infectious Mononucleosis: A Matter of Luck or Genetic Predisposition? by Theocharis Koufakis, Ioannis Gabranis

“…More studies are required in order to clarify the pathophysiological and genetic backgrounds that connect acalculous cholecystitis and EBV infection.…”
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Does Depression Impact Cognitive Impairment in Patients with Heart Failure? by Z. N. Sohani, Z. Samaan

“…Evidence from literature supports the possibility of a pathophysiological relationship between cognitive impairment, depression, and heart failure. …”
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Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord by Tamara Janković, Jelena Rajič Bumber, Nika Gržeta Krpan, Petra Dolenec, Marc Jaeger, Jasna Kriz, Gordana Župan, Kristina Pilipović

“…Initial brain trauma triggers secondary pathophysiological processes that induce structural and functional impairment of the central nervous system, even in the regions distant to the lesion site. …”
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Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study by Xiaozheng Liu, Yunhai Tu, Yirou Zang, Aiqin Wu, Zhongwei Guo, Jiawei He

“…These results suggest that the sensorimotor network may be one of the main pathophysiological factors in D-MCI.…”
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Ferroptosis in Macrophage Impairment in Sepsis by Hongxuan Liu, Lei Li

“…Up to now, ferroptosis has been proved to be involved in the pathophysiological mechanism of many diseases, such as Alzheimer’s disease, cancer, Parkinson’s disease, and renal degeneration. …”
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The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation by Chao Zhang, Shuo Wang, Cheng Yang, Ruiming Rong

“…Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. …”
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. …”
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Inflammatory Myofibroblastic Tumor of the Trachea with Concomitant Granulomatous Lymph Node Lesions by Julia Anne Koch, Patrick Dorn, Thierry Rausch, Hans-Beat Ris, Hans-Anton Lehr, Stephan C. Schäfer

“…The discussion of the case circles around putative pathophysiological links between the lesions. The authors favor the idea that the lymph nodes present a sarcoid-like granulomatous reaction to the inflammatory myofibroblastic tumor in the trachea over a coexistence of two independent entities. …”
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Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes by Lin Ding, Shuguang Pang, Yongmei Sun, Yuling Tian, Li Yu, Ningning Dang

“…Here we review the recent progress concerning the physiological and pathophysiological roles of FXRs and LXRs in the regulation of bile acid, lipid and glucose metabolism and the implications in T2D, taking into account that these two nuclear receptors are potential pharmaceutical targets for the treatment of T2D and its complications.…”
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Acute Coronary Syndrome after 17 Years of Bare Metal Stent Implantation: “Very” Very Late Stent Thrombosis by Raghavendra Rao K, S. Reddy, J. R. Kashyap, K. Vikas, Hithesh Reddy, Vadivelu Ramalingam

“…VLST is a rare entity with drug-eluting stents and even rarer with bare metal stents. The exact pathophysiologic mechanism of VLST after BMS implantation is not known although various mechanisms have been proposed. …”
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Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? by Theocharis Koufakis, Ioannis Gabranis, Marianneta Chatzopoulou, Anastasios Margaritis, Maria Tsiakalou

“…More studies are required in order to clarify the underlying pathophysiological mechanisms that connect asplenia, immunological response to Legionella, and pathogen’s resistance to antibiotics.…”
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The role of NF-κB in diabetic cardiomyopathy by Huang-Jun Liu, Le-Kun Gui, Han Wei, Xing-Yu Zhou, Zhen-Lan Liu, Li-Jun Jin

“…Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. …”
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A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment by Aoling Huang, Haochen Xue, Ting Xie, Lingyan Xiang, Zhengzhuo Chen, Aolong Ma, Honglin Yan, Jingping Yuan

“…Altered mitochondrial function plays a critical role in various diseases, and recent studies have elucidated its pathophysiological mechanisms in breast carcinogenesis. …”
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IMPACT OF ORTHODONTIC DYSFUNCTIONS ON THE DEVELOPMENT OF JOINT OSTEOARTHRITIS by Oleg Solomon, Norina Consuela Forna, Doriana Agop Forna, Irina Adriana Beuran, Diana Cornea, Kamel Earar

“…This article investigates the mechanisms by which orthodontic dysfunctions can accelerate TMJ degeneration, emphasizing the influence of biomechanical and pathophysiological factors. Understanding the connection between dental malpositions and osteoarthritis is essential for establishing effective methods of prevention and treatment, having the potential to reduce the incidence and severity of osteoarthritis among patients with orthodontic dysfunctions. …”
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